2024
Responding to threat: Associations between neural reactivity to and behavioral avoidance of threat in pediatric anxiety
Kitt E, Zacharek S, Odriozola P, Nardini C, Hommel G, Martino A, Anderson T, Spencer H, Broussard A, Dean J, Marin C, Silverman W, Lebowitz E, Gee D. Responding to threat: Associations between neural reactivity to and behavioral avoidance of threat in pediatric anxiety. Journal Of Affective Disorders 2024, 351: 818-826. PMID: 38290579, PMCID: PMC10981528, DOI: 10.1016/j.jad.2024.01.204.Peer-Reviewed Original ResearchConceptsReactivity to threatMeasures of avoidanceVentral anterior insulaClinician-based measuresNeural reactivityPediatric anxietyAnxiety disordersBehavioral avoidanceFunctional magnetic resonance imaging taskAmygdala functional connectivityVentromedial prefrontal cortexTreatment-seeking sampleAvoidance of threatClinically significant constructsAssociated with tasksGeneralizability of findingsPrefrontal cortexAnterior insulaNeural findingsLaboratory tasksFunctional connectivityAnxietyAmygdalaAvoidanceSignificant constructs
2023
Assessing Anxiety-Related Impairment in Children and Adolescents
Etkin R, Lebowitz E, Silverman W. Assessing Anxiety-Related Impairment in Children and Adolescents. Assessment 2023, 31: 94-109. PMID: 37840296, DOI: 10.1177/10731911231194972.Peer-Reviewed Original ResearchDoes Cognitive-Behavioral Therapy for Youth Anxiety Disorders Improve Social Functioning and Peer Relationships?
Etkin R, Juel E, Lebowitz E, Silverman W. Does Cognitive-Behavioral Therapy for Youth Anxiety Disorders Improve Social Functioning and Peer Relationships? Clinical Child And Family Psychology Review 2023, 26: 1052-1076. PMID: 37838627, DOI: 10.1007/s10567-023-00454-3.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCognitive behavioral therapyAdolescent anxiety disordersPeer relationshipsSocial functioningAnxiety disordersYouth anxiety disordersPeer outcomesAnxiety reductionTreatment-specific effectsFunctioningTreatment specificitySystematic narrative reviewRelated difficultiesSample characteristicsMajority of studiesSpecific outcomesChildrenTreatment outcomesStatistical findingsStudy sampleDisordersNarrative reviewFindingsRelationshipAnxietyAffective Language Spreads Between Anxious Children and Their Mothers During a Challenging Puzzle Task
Nook E, Nardini C, Zacharek S, Hommel G, Spencer H, Martino A, Morra A, Flores S, Anderson T, Marin C, Silverman W, Lebowitz E, Gee D. Affective Language Spreads Between Anxious Children and Their Mothers During a Challenging Puzzle Task. Emotion 2023, 23: 1513-1521. PMID: 36595385, PMCID: PMC10314965, DOI: 10.1037/emo0001203.Peer-Reviewed Original ResearchConceptsNegative affect wordsChallenging puzzle taskAffect wordsAffective languagePuzzle taskEffective emotion regulationSpread of emotionsEmotion regulationNeuroscientific levelAnxious childrenEmotional influencesWord useBidirectional influenceAnxiety disordersBidirectional relationsMother's directionsMental healthEmotionsFuture researchWordsCurrent studyLanguageChildrenTaskMothersEffect modification of an effective transdiagnostic cognitive behavioral psychotherapy in youths with common mental health problems: Secondary analyses of the randomized mind-my-mind trial
Rimvall M, Vassard D, Nielsen S, Wolf R, Plessen K, Bilenberg N, Thomsen P, Thastum M, Neumer S, Puggaard L, Pedersen M, Pagsberg A, Silverman W, Correll C, Christensen R, Jeppesen P. Effect modification of an effective transdiagnostic cognitive behavioral psychotherapy in youths with common mental health problems: Secondary analyses of the randomized mind-my-mind trial. European Neuropsychopharmacology 2023, 74: 64-75. PMID: 37279641, DOI: 10.1016/j.euroneuro.2023.05.004.Peer-Reviewed Original ResearchConceptsMental health problemsPotential effect modifiersHealth problemsDifferential treatment effectsTreatment benefitEffect modifiersUntreated mental health problemsSubstantial mental health problemsCommon mental health problemsTreatment effectsLocal community settingsCommunity-based programsBaseline factorsTreat analysisClinical variablesEffect modificationCognitive-behavioral psychotherapyDiagnostic criteriaMIND trialSociodemographic factorsTrial dataMental disordersSecondary analysisCommunity settingsCBT treatmentAssociation between specific types of parent stressors and fast-food consumption among parents and children
Bautista T, Fogelman N, Lartigue S, Silverman W, Jastreboff A, Sinha R. Association between specific types of parent stressors and fast-food consumption among parents and children. Eating Behaviors 2023, 49: 101724. PMID: 37054487, PMCID: PMC10247538, DOI: 10.1016/j.eatbeh.2023.101724.Peer-Reviewed Original ResearchConceptsHousehold chaosParent stressorsYoung childrenOnly significant predictorSignificant predictorsFast food consumptionStress interventionsSeparate regression modelsParentsSpecific typesYear oldsChildrenStressorsFast food intakeChildren's fast food consumptionPredictorsFinal modelHealthy foodsOldsBehaviorStressInterventionTurnBody mass indexFindingsParent Accommodation Contemporaneously Mediates the Association Between Youth Irritability and Youth Anxiety Treatment Outcome
Cabrera V, Buitron V, Patriarca G, Rey Y, Lebowitz E, Silverman W, Pettit J. Parent Accommodation Contemporaneously Mediates the Association Between Youth Irritability and Youth Anxiety Treatment Outcome. Behavior Therapy 2023, 54: 852-862. PMID: 37597962, PMCID: PMC10440415, DOI: 10.1016/j.beth.2023.03.002.Peer-Reviewed Original ResearchConceptsYouth anxiety severityParent accommodationCognitive-behavioral treatmentYouth irritabilityAnxiety treatment outcomesAnxiety severityChild anxietyPrimary anxiety disorder diagnosisAnxiety disorder diagnosisAnxious youthYouth anxietyYouth ages 6Adolescent irritabilityAnxiety outcomesBehavioral treatmentAnxiety protocolAnxietyGreater impairmentDisorder diagnosisAge 6Treatment outcomesFuture researchPosttreatmentIrritabilityResearch documentsThe Therapy Process Observational Coding System: Group cohesion scale in youth anxiety treatment: Psychometric properties
Fjermestad K, McLeod B, Silverman W, Bjaastad J, Lerner M, Wergeland G. The Therapy Process Observational Coding System: Group cohesion scale in youth anxiety treatment: Psychometric properties. Journal Of Clinical Psychology 2023, 79: 1726-1739. PMID: 36799300, DOI: 10.1002/jclp.23496.Peer-Reviewed Original ResearchMaternal FGF2 levels associated with child anxiety and depression symptoms through child FGF2 levels
Lebowitz E, Marin C, Orbach M, Salmaso N, Vaccarino F, Silverman W. Maternal FGF2 levels associated with child anxiety and depression symptoms through child FGF2 levels. Journal Of Affective Disorders 2023, 326: 193-197. PMID: 36717031, PMCID: PMC10104478, DOI: 10.1016/j.jad.2023.01.090.Peer-Reviewed Original ResearchConceptsFGF2 levelsDepressive symptomsDepression symptomsChild anxietySymptoms of anxietyRatings of anxietyGrowth factor 2Maternal anxietySymptomsDepressed childrenDepressionChild depressionMothersChildrenFactor 2Self-report ratingsAnxietyIntergenerational pathwaysNon-referred childrenRange of anxietyFGF2AssociationLevelsMaternalEditorial Statement About JCCAP’s 2023 Special Issue on Informant Discrepancies in Youth Mental Health Assessments: Observations, Guidelines, and Future Directions Grounded in 60 Years of Research
De Los Reyes A, Epkins C, Asmundson G, Augenstein T, Becker K, Becker S, Bonadio F, Borelli J, Boyd R, Bradshaw C, Burns G, Casale G, Causadias J, B. C, Chorpita B, Cohen J, Comer J, Crowell S, Dirks M, Drabick D, DuPaul G, Ehrlich K, Evans S, Evans S, Felton J, Fite P, Gadow K, Galán C, Garbacz S, Gaylord-Harden N, Humphreys K, Gerber A, Hogue A, Ivanova M, Jarrett M, Jensen-Doss A, Kang E, Kendall P, Laird R, Langberg J, Langer D, Lee S, Lerner M, Lippold M, Luebbe A, Makol B, McLeod B, McMahon R, Miller M, Ohannessian C, Ollendick T, Piña A, Prinstein M, Rabinowitz J, Reynolds E, Salekin R, Schleider J, Scott J, Tackett J, Talbott E, Silverman W, Spears A, von der Embse N, Wakschlag L, Wang M, Watts A, Weisz J, White B, White S, Youngstrom E. Editorial Statement About JCCAP’s 2023 Special Issue on Informant Discrepancies in Youth Mental Health Assessments: Observations, Guidelines, and Future Directions Grounded in 60 Years of Research. Journal Of Clinical Child & Adolescent Psychology 2023, 52: 147-158. PMID: 36652590, DOI: 10.1080/15374416.2022.2158842.Peer-Reviewed Original Research
2022
Parent Involvement Enhances CBTs for Anxiety Disorders in Hispanic/Latino Youth: Acculturation as a Moderator
Patriarca G, Rey Y, Marin C, Yeguez C, Pettit J, Silverman W. Parent Involvement Enhances CBTs for Anxiety Disorders in Hispanic/Latino Youth: Acculturation as a Moderator. Journal Of Consulting And Clinical Psychology 2022, 90: 827-836. PMID: 36355650, PMCID: PMC9727821, DOI: 10.1037/ccp0000770.Peer-Reviewed Original ResearchConceptsCognitive-behavioral treatmentAnxiety outcomesParent acculturationAnxiety disordersPsychological controlNegative reinforcementEfficacy of CBTParents’ psychological controlYouth anxiety severityHispanic/Latino youthEvidence-based interventionsYouth ages 6Anxiety severityBehavioral treatmentParents' useLatino youthLatino familiesParent involvementAge 6YouthAcculturation levelAcculturationEnculturationModeratorDisordersMitigating Multiple Sources of Bias in a Quasi-Experimental Integrative Data Analysis: Does Treating Childhood Anxiety Prevent Substance Use Disorders in Late Adolescence/Young Adulthood?
Saavedra LM, Morgan-López AA, West SG, Alegría M, Silverman WK. Mitigating Multiple Sources of Bias in a Quasi-Experimental Integrative Data Analysis: Does Treating Childhood Anxiety Prevent Substance Use Disorders in Late Adolescence/Young Adulthood? Prevention Science 2022, 24: 1622-1635. PMID: 36057023, DOI: 10.1007/s11121-022-01422-z.Peer-Reviewed Original ResearchConceptsStudy-related treatmentYoung adulthoodPropensity scoreLong-term followDrug use disordersAdolescence/young adulthoodQuasi-experimental designLate adolescence/young adulthoodClinical trialsSubstance use disorder severityLong-term effectsChild anxiety disordersEpidemiological studiesIntegrative data analysisAnxiety disorder treatmentUse disordersDisorder treatmentAnxiety disordersControl participantsEpidemiological sampleClinical samplesDisorder severityTrialsLong-term assessmentDisordersAge and depressive symptoms change predict the 4‐year self‐concept trajectory for youth after anxiety treatment
Fjermestad KW, Bellika K, Matre C, Silverman WK, Wergeland GJ. Age and depressive symptoms change predict the 4‐year self‐concept trajectory for youth after anxiety treatment. Journal Of Clinical Psychology 2022, 78: 2109-2121. PMID: 35975330, PMCID: PMC9804830, DOI: 10.1002/jclp.23427.Peer-Reviewed Original ResearchAttention Training as a Low-Intensity Treatment for Concerning Anxiety in Clinic-Referred Youth
Pettit J, Rey Y, Marin C, Bechor M, Lebowitz E, Vasey M, Jaccard J, Abend R, Pine D, Bar-Haim Y, Silverman W. Attention Training as a Low-Intensity Treatment for Concerning Anxiety in Clinic-Referred Youth. Behavior Therapy 2022, 54: 77-90. PMID: 36608979, PMCID: PMC9825787, DOI: 10.1016/j.beth.2022.07.004.Peer-Reviewed Original ResearchConceptsAttention Bias Modification TreatmentAttention control trainingAttention trainingAnxiety severityAttention controlAnxiety levelsAttention biasNeutral facesLow-intensity treatmentGlobal impairmentDot-probe taskYouth anxiety severityClinic-Referred YouthFull criteriaAttention focusingControl trainingTreatment researchYouthIndependent evaluatorsTrainingImpairment ratingsACT trialsPosttreatmentSeverity ratingsRatingsYouth social functioning interacts with treatment arm, diagnosis, and gender to predict anxiety treatment outcome
Etkin RG, Marin CE, Silverman WK, Lebowitz ER. Youth social functioning interacts with treatment arm, diagnosis, and gender to predict anxiety treatment outcome. Behaviour Research And Therapy 2022, 156: 104160. PMID: 35870327, DOI: 10.1016/j.brat.2022.104160.Peer-Reviewed Original ResearchConceptsAnxiety treatment outcomesYouth social functioningSocial skillsPositive social interactionsSocial functioningAnxiety diagnosesAnxiety disordersSocial interactionParent-based treatmentChildren's social skillsSocial anxiety disorderYouths' social skillsAnxiety symptom severityYouth genderTreatment outcomesDiagnostic InterviewSymptom severityClinical functioningFunctioningSkillsYouthPredictorsMultiple regression modelDisordersGenderCost-effectiveness of a transdiagnostic psychotherapy program for youth with common mental health problems
Wolf RT, Jeppesen P, Pedersen MMA, Puggaard LB, Thastum M, Bilenberg N, Thomsen PH, Silverman WK, Plessen KJ, Neumer SP, Correll CU, Pagsberg AK, Gyrd-Hansen D. Cost-effectiveness of a transdiagnostic psychotherapy program for youth with common mental health problems. BMC Health Services Research 2022, 22: 819. PMID: 35739556, PMCID: PMC9229821, DOI: 10.1186/s12913-022-08187-9.Peer-Reviewed Original ResearchConceptsIncremental cost-effectiveness ratioCommon mental health problemsMental health problemsHealth problemsChild Health Utility 9DTrial periodCost-effectiveness ratioPreference weightsAdult populationLife reportingPsychotherapy programSelf-reported costsCHU9DThree timesTrialsChoice of informantsTreatment effectsObjectivesOur objectiveYouth QualitySchool-age youthYouth populationWeightParent Stress and Trauma, Autonomic Responses, and Negative Child Behaviors
Fogelman N, Schwartz J, Chaplin TM, Jastreboff AM, Silverman WK, Sinha R. Parent Stress and Trauma, Autonomic Responses, and Negative Child Behaviors. Child Psychiatry & Human Development 2022, 54: 1779-1788. PMID: 35674991, PMCID: PMC9729425, DOI: 10.1007/s10578-022-01377-w.Peer-Reviewed Original ResearchConceptsNegative child behaviorsTraumatic life eventsParent stressChild behaviorLife eventsParent-child interactionsChild behavioral outcomesGreater heart rate variabilityRecent life eventsChildren's attentionBehavioral outcomesHeart rate variabilityPhysiological copingYear old childrenLife stressAggressive behaviorCumulative stressOlder childrenMore parentsInteraction challengesAutonomic responsesParentsMajor lifeMore childrenChildrenThe role of attentional shifting in the relation between error monitoring and anxiety in youth
Ramos ML, Bechor M, Casas A, Pettit JW, Silverman WK, Reeb-Sutherland BC. The role of attentional shifting in the relation between error monitoring and anxiety in youth. Psychiatry Research Neuroimaging 2022, 324: 111507. PMID: 35675720, PMCID: PMC9730549, DOI: 10.1016/j.pscychresns.2022.111507.Peer-Reviewed Original ResearchConceptsError-related negativityAttentional controlERN amplitudeNeural responsesMaintenance of anxietyLarger neural responsesSelf-report measuresSmaller neural responseAttentional shiftingFlanker taskError monitoringThreat signalsAnxiety symptomsNeural markersAnxietyYouthSimultaneous EEGResponse magnitudeAttentionNegativityAbilityHigh abilityTaskLow levelsEEGWhole‐exome DNA sequencing in childhood anxiety disorders identifies rare de novo damaging coding variants
Olfson E, Lebowitz ER, Hommel G, Pashankar N, Silverman WK, Fernandez TV. Whole‐exome DNA sequencing in childhood anxiety disorders identifies rare de novo damaging coding variants. Depression And Anxiety 2022, 39: 474-484. PMID: 35312124, PMCID: PMC9246845, DOI: 10.1002/da.23251.Peer-Reviewed Original ResearchConceptsWhole-exome DNA sequencingRisk genesDNA sequencingCanonical biological pathwaysMissense genetic variantsNovo variantsGenetic variant detectionParent-child triosGenomic approachesDe novo variantsLikely geneBiologic pathwaysDeleterious variantsBiological pathwaysDamaging variantsGenesGenetic variantsPathwayVariant detectionSequencingNetwork analysisGenetic factorsUnderlying biologyVariantsEnrichmentSociodemographic and clinical characteristics of youths and parents seeking psychological treatment for school attendance problems
Johnsen DB, Lomholt JJ, Heyne D, Jeppesen P, Jensen MB, Silverman WK, Thastum M. Sociodemographic and clinical characteristics of youths and parents seeking psychological treatment for school attendance problems. PLOS ONE 2022, 17: e0261449. PMID: 35081106, PMCID: PMC8791456, DOI: 10.1371/journal.pone.0261449.Peer-Reviewed Original ResearchConceptsMental health problemsSchool attendance problemsPsychological treatmentHelp-seeking youthHealth problemsAttendance problemsClinical characteristicsBehavioral difficultiesCross-sectional designNegative outcomesOlder youthYouthEarly interventionClinical levelParentsTreatment startBaseline assessmentSchool absenceSociodemographic characteristicsTreatmentAnxietyHigh levelsLow levelsDepressionAbsence