2020
Evaluation of the New American Urological Association Guidelines Risk Classification for Hematuria
Woldu S, Ng C, Loo R, Slezak J, Jacobsen S, Tan W, Kelly J, Lough T, Darling D, van Kessel K, de Jong J, van Criekinge W, Shariat S, Hiar A, Brown S, Boorjian S, Barocas D, Svatek R, Lotan Y. Evaluation of the New American Urological Association Guidelines Risk Classification for Hematuria. Journal Of Urology 2020, 205: 1387-1392. PMID: 33356483, DOI: 10.1097/ju.0000000000001550.Peer-Reviewed Original ResearchConceptsIncidence of bladder cancerBladder cancerHigh-risk groupRisk groupsRisk strataCancer incidenceDegree of hematuriaHigh-risk patientsRisk stratification systemAmerican Urological AssociationEvaluation of patientsMultinational cohort studyRisk-stratified approachBladder cancer incidenceHematuria patientsClinically meaningful categoriesGross hematuriaUrologic evaluationIntermediate riskProspective registryRisk patientsContemporary patientsSmoking historyUrological AssociationHematuriaSpontaneous Ureterocutaneous Fistula Secondary to Obstructed Ureteric Stone
Mukherjee S, Sinha R, Mandal S, Tan W. Spontaneous Ureterocutaneous Fistula Secondary to Obstructed Ureteric Stone. Urology 2020, 138: e5-e7. PMID: 31958535, DOI: 10.1016/j.urology.2020.01.013.Peer-Reviewed Original Research
2019
Variation in Positive Surgical Margin Status After Radical Prostatectomy for pT2 Prostate Cancer
Tan W, Krimphove M, Cole A, Marchese M, Berg S, Lipsitz S, Löppenberg B, Nabi J, Abdollah F, Choueiri T, Kibel A, Sooriakumaran P, Trinh Q. Variation in Positive Surgical Margin Status After Radical Prostatectomy for pT2 Prostate Cancer. Clinical Genitourinary Cancer 2019, 17: e1060-e1068. PMID: 31303561, DOI: 10.1016/j.clgc.2019.06.008.Peer-Reviewed Original ResearchConceptsPositive surgical marginsFactors associated with positive surgical marginsPositive surgical margin statusPT2 prostate cancerRadical prostatectomyProstate cancerCancer-specific factorsSurgical approachMargin statusHigher hospital surgical volumeSurgical margin statusNational Cancer DatabaseHospital surgical volumeCancer-specific featuresPSM rateSurgical marginsCancer DatabaseImprove patient outcomesEvaluating patientsContribution of patientLogistic regression modelsSurgical volumeProstatectomyPatientsPatient-specificDevelopment and validation of a haematuria cancer risk score to identify patients at risk of harbouring cancer
Tan W, Ahmad A, Feber A, Mostafid H, Cresswell J, Fankhauser C, Waisbrod S, Hermanns T, Sasieni P, Kelly J, Khetrapal P, Baker H, Sridhar A, Lamb B, Ocampo F, McBain H, Baillie K, Middleton K, Watson D, Knight H, Maher S, Rane A, Pathmanathan B, Harmathova A, Hellawell G, Pelluri S, Pati J, Cossons A, Scott C, Madaan S, Bradfield S, Wakeford N, Dann A, Cook J, Cornwell M, Mills R, Thomas S, Reyner S, Vallejera G, Adeniran P, Masood S, Whotton N, Dent K, Pearson S, Hatton J, Newton M, Heeney E, Green K, Evans S, Rogers M, Gupwell K, Whiteley S, Brown A, McGrath J, Lunt N, Hill P, Sinclair A, Paredes‐Guerra A, Holbrook B, Ong E, Wardle H, Wilson D, Bayles A, Fennelly R, Tribbeck M, Ames K, Davies M, Taylor J, Edmunds E, Moore J, Mckinley S, Nolan T, Speed A, Tunnicliff A, Fossey G, Williams A, George M, Hutchins I, Einosas R, Richards A, Henderson A, Appleby B, Kehoe L, Gladwell L, Drakeley S, Davies J, Krishnan R, Roberts H, Main C, Jain S, Dumville J, Wilkinson N, Taylor J, Thomas F, Goulden K, Vinod C, Green E, Waymont C, Rogers J, Grant A, Carter V, Heap H, Lomas C, Cooke P, Scarratt L, Hodgkiss T, Johnstone D, Johnson J, Allsop J, Rothwell J, Connolly K, Cherian J, Ridgway S, Coulding M, Savill H, Mccormick J, Clark M, Collins G, Jewers K, Keith S, Bowen G, Hargreaves J, Riley K, Srirangam S, Rees A, Williams S, Dukes S, Goffe A, Dawson L, Mistry R, Chadwick J, Cocks S, Hull R, Loftus A, Baird Y, Moore S, Greenslade S, Margalef J, Chadbourn I, Harris M, Hicks J, Clitheroe P, Connolly S, Hodgkinson S, Haydock H, Sinclair A, Storr E, Cogley L, Natale S, Lovegrove W, Slack K, Nash D, Smith K, Walsh J, Guerdette A, Hill M, Payne D, Taylor B, Sinclair E, Perry M, Debbarma M, Hewitt D, Sriram R, Power A, Cannon J, Devereaux L, Thompson A, Atkinson K, Royle L, Madine J, MacLean K, Sarpong R, Brew‐Graves C, Williams N. Development and validation of a haematuria cancer risk score to identify patients at risk of harbouring cancer. Journal Of Internal Medicine 2019, 285: 436-445. PMID: 30521125, PMCID: PMC6446724, DOI: 10.1111/joim.12868.Peer-Reviewed Original ResearchConceptsCancer risk scoreNational Institute for Health and Clinical Excellence guidelinesRisk scoreInvestigation of haematuriaPhysician decision-makingAge-specific thresholdsValidation cohortExcellence guidelinesUK hospitalsAmerican Urological Association guidelinesNational guidelinesImprove patientNo significant overfittingImprove patient selectionUpper tract cancerLack of consensusAssociation guidelinesSmoking historySwiss patientsCohortPatient ageDevelopment cohortPatient selectionGuidelinesHaematuria
2018
Who Should Be Investigated for Haematuria? Results of a Contemporary Prospective Observational Study of 3556 Patients
Tan W, Feber A, Sarpong R, Khetrapal P, Rodney S, Jalil R, Mostafid H, Cresswell J, Hicks J, Rane A, Henderson A, Watson D, Cherian J, Williams N, Brew-Graves C, Kelly J, collaborators O. Who Should Be Investigated for Haematuria? Results of a Contemporary Prospective Observational Study of 3556 Patients. European Urology 2018, 74: 10-14. PMID: 29653885, DOI: 10.1016/j.eururo.2018.03.008.Peer-Reviewed Original ResearchConceptsUrinary tract cancerIncidence of urinary tract cancerInvestigation of haematuriaRisk of urinary tract cancerClinically significant cancerDiagnosis of urinary tract cancerHigh-risk cancerProspective observational studyIncidence of cancerSignificant cancerAge thresholdBladder cancerSmoking historyVisible bloodOlder patientsHaematuriaMale genderConsensus recommendationsPatientsObservational studyCancerPatient preferencesCancer diagnosisLack of consensusAge
2017
Intracorporeal robot‐assisted radical cystectomy, together with an enhanced recovery programme, improves postoperative outcomes by aggregating marginal gains
Tan W, Tan M, Lamb B, Sridhar A, Mohammed A, Baker H, Nathan S, Briggs T, Tan M, Kelly J. Intracorporeal robot‐assisted radical cystectomy, together with an enhanced recovery programme, improves postoperative outcomes by aggregating marginal gains. BJU International 2017, 121: 632-639. PMID: 29124853, DOI: 10.1111/bju.14073.Peer-Reviewed Original ResearchConceptsLength of hospital stayOpen radical cystectomyRobot-assisted radical cystectomyPeri-operative outcomesRadical cystectomyERAS programmeERAS groupERAS pathwayReadmission ratesOpen radical cystectomy groupAmerican Society of Anesthesiologists scoreIntracorporeal robot-assisted radical cystectomyPeri-operative anaemiaLymph node yieldRadical cystectomy casesClavien-Dindo systemScore-matched cohort of patientsCohort of patientsLevel 1 evidenceImproving postoperative outcomesIntracorporeal urinary diversionBody mass indexScore-matched cohortGastrointestinal-related complicationsPrimary outcome measureUroMark—a urinary biomarker assay for the detection of bladder cancer
Feber A, Dhami P, Dong L, de Winter P, Tan W, Martínez-Fernández M, Paul D, Hynes-Allen A, Rezaee S, Gurung P, Rodney S, Mehmood A, Villacampa F, de la Rosa F, Jameson C, Cheng K, Zeegers M, Bryan R, James N, Paramio J, Freeman A, Beck S, Kelly J. UroMark—a urinary biomarker assay for the detection of bladder cancer. Clinical Epigenetics 2017, 9: 8. PMID: 28163793, PMCID: PMC5282868, DOI: 10.1186/s13148-016-0303-5.Peer-Reviewed Original ResearchConceptsDetection of bladder cancerEpigenetic alterationsSequencing assayNovel high-throughputBladder cancerBackgroundBladder cancerNext-generation sequencing assayUrinary biomarkersDNA methylationMuscle-invasive bladder cancerUrinary biomarker assaysSediment DNAAnalysis pipelineVoided urine samplesDetection of BCPrimary BCHigh-throughputCystoscopic examinationVoided urineDNAIndependent cohortAssayBiomarker panelDiagnosed BCCancerBlood Transfusion Requirement and Not Preoperative Anemia Are Associated with Perioperative Complications Following Intracorporeal Robot-Assisted Radical Cystectomy
Tan W, Lamb B, Khetrapal P, Tan M, Tan M, Sridhar A, Cervi E, Rodney S, Busuttil G, Nathan S, Hines J, Shaw G, Mohammed A, Baker H, Briggs T, Klein A, Richards T, Kelly J. Blood Transfusion Requirement and Not Preoperative Anemia Are Associated with Perioperative Complications Following Intracorporeal Robot-Assisted Radical Cystectomy. Journal Of Endourology 2017, 31: 141-148. PMID: 27901350, DOI: 10.1089/end.2016.0730.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnemiaBlood Loss, SurgicalBlood TransfusionCystectomyFemaleHumansMaleMiddle AgedNeoadjuvant TherapyPerioperative PeriodPostoperative ComplicationsPreoperative PeriodPrevalenceProspective StudiesRobotic Surgical ProceduresTransfusion ReactionUrinary Bladder NeoplasmsUrinary DiversionConceptsBlood transfusion requirementsAssociated with perioperative morbidityPreoperative anemiaTransfusion requirementsBlood transfusionComplication ratePerioperative morbidityAssociated with increased surgical riskPresence of preoperative anemiaPrevalence of preoperative anemiaAssociated with increased perioperative morbidityAssociated with perioperative complicationsImpact of preoperative anemiaAssociated with increased complicationsPostoperative blood transfusion rateLower lymph node yieldPostoperative blood transfusion requirementsRobot-assisted radical cystectomyPreoperatively anemic patientsIntraoperative blood transfusionLymph node yieldPostoperative blood transfusionBlood transfusion rateClavien-Dindo systemHospital length of stay
2016
Well-Differentiated Papillary Mesothelioma of the Tunica Vaginalis: Case Report and Systematic Review of Literature
Tan W, Tan M, Tan W, Gan S, Pathmanathan R, Tan H, Tan W. Well-Differentiated Papillary Mesothelioma of the Tunica Vaginalis: Case Report and Systematic Review of Literature. Clinical Genitourinary Cancer 2016, 14: e435-e439. PMID: 27067374, DOI: 10.1016/j.clgc.2016.03.007.Peer-Reviewed Original Research
2013
Efficacy and safety of long‐acting intramuscular testosterone undecanoate in aging men: a randomised controlled study
Tan W, Low W, Ng C, Tan W, Tong S, Ho C, Khoo E, Lee G, Lee B, Lee V, Tan H. Efficacy and safety of long‐acting intramuscular testosterone undecanoate in aging men: a randomised controlled study. BJU International 2013, 111: 1130-1140. PMID: 23651425, DOI: 10.1111/bju.12037.Peer-Reviewed Original ResearchConceptsProstate-specific antigenTestosterone undecanoateTestosterone deficiencyTreatment armsAdverse eventsSex hormone-binding globulinIntramuscular testosterone undecanoateCommon adverse eventsIncreased serum testosteroneHormone-binding globulinLiver function testsCessation of treatmentFasting blood glucosePhysical examination resultsRandomised controlled studySite of injectionTU injectionsPlacebo armSerum TTSerum testosteroneSpecific antigenAdverse reactionsLipid profileFunction testsControlled studies
2011
The triad of erectile dysfunction, testosterone deficiency syndrome and metabolic syndrome: findings from a multi-ethnic Asian men study (The Subang Men’s Health Study)
Tan W, Ng C, Khoo E, Low W, Tan H. The triad of erectile dysfunction, testosterone deficiency syndrome and metabolic syndrome: findings from a multi-ethnic Asian men study (The Subang Men’s Health Study). The Aging Male 2011, 14: 231-236. PMID: 22115177, DOI: 10.3109/13685538.2011.597463.Peer-Reviewed Original ResearchConceptsEtiology of erectile dysfunctionTestosterone deficiency syndromeFasting blood glucoseMetabolic syndromeMS componentsSelf-reported medical problemsDeficiency syndromeErectile dysfunctionInternational Index of Erectile FunctionSocio-demographic dataIndex of Erectile FunctionElevated fasting blood glucoseModerate-severe EDPredictors of EDElevated blood pressureHigher disease burdenMultivariate regression analysisAge of menIIEF-5Erectile functionDisease burdenPhysical examinationInternational IndexLipid profileUrban settings