2023
Robot-assisted Radical Cystectomy Versus Open Radical Cystectomy: A Systematic Review and Meta-analysis of Perioperative, Oncological, and Quality of Life Outcomes Using Randomized Controlled Trials
Khetrapal P, Wong J, Tan W, Rupasinghe T, Tan W, Williams S, Boorjian S, Wijburg C, Parekh D, Wiklund P, Vasdev N, Khan M, Guru K, Catto J, Kelly J. Robot-assisted Radical Cystectomy Versus Open Radical Cystectomy: A Systematic Review and Meta-analysis of Perioperative, Oncological, and Quality of Life Outcomes Using Randomized Controlled Trials. European Urology 2023, 84: 393-405. PMID: 37169638, DOI: 10.1016/j.eururo.2023.04.004.Peer-Reviewed Original ResearchMeSH KeywordsCystectomyHumansPostoperative ComplicationsQuality of LifeRandomized Controlled Trials as TopicRobotic Surgical ProceduresRoboticsTreatment OutcomeUrinary Bladder NeoplasmsConceptsRobot-assisted radical cystectomyOpen radical cystectomyRadical cystectomyBlood lossThromboembolic eventsAssociated with better physical functionBladder cancerPositive surgical margin rateAssociated with more blood lossRisk of thromboembolic eventsHealth-related QoLQuality of life outcomesProgression-free survivalSurgical margin rateLymph node yieldRobot-assisted approachShorter operative timeShorter hospital lengthQuality of lifeRandomized controlled trialsSystematic literature searchPhysical functionWeb of ScienceNode yieldOverall survival
2021
Recovery of health‐related quality of life in patients undergoing robot‐assisted radical cystectomy with intracorporeal diversion
Abozaid M, Tan W, Khetrapal P, Baker H, Duncan J, Sridhar A, Briggs T, Selim M, Abdallah M, Elmahdy A, Elserafy F, Kelly J. Recovery of health‐related quality of life in patients undergoing robot‐assisted radical cystectomy with intracorporeal diversion. BJU International 2021, 129: 72-79. PMID: 34092021, DOI: 10.1111/bju.15505.Peer-Reviewed Original ResearchConceptsGlobal HRQoL scoreHealth-related quality of lifeRobot-assisted radical cystectomyEORTC QLQ-C30HRQoL scoresQuality of lifeSexual functionRadical cystectomyUrinary diversionIleal conduitIC patientsRecovery of health-related quality of lifeFunction scoresClavien-Dindo complicationsHealth-related qualityPhysical function scoresRehabilitation of sexual functionIntracorporeal urinary diversionLongitudinal analysisSexual function scoresEuropean Organisation for ResearchMonths follow-upEORTC QLQ-BLM30Higher sexual function scoresReturn to baselineCurrent application of the enhanced recovery after surgery protocol for patients undergoing radical cystectomy: lessons learned from European excellence centers
Albisinni S, Moschini M, Di Trapani E, Soria F, Mari A, Aziz A, Teoh J, Laukhtina E, Mori K, D’Andrea D, Carrion D, Krajewski W, Abufaraj M, Cimadamore A, Tan W, Flippot R, Khalifa J, Gonsette K, Pradere B. Current application of the enhanced recovery after surgery protocol for patients undergoing radical cystectomy: lessons learned from European excellence centers. World Journal Of Urology 2021, 40: 1317-1323. PMID: 34076754, DOI: 10.1007/s00345-021-03746-x.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidAnticoagulantsCystectomyEnhanced Recovery After SurgeryHumansLength of StayPostoperative ComplicationsVenous ThromboembolismConceptsOpioid-sparing anesthesiaRadical cystectomyERAS implementationPreoperative carbohydrate loadingEuropean expert centersImplementation of ERASBowel preparationERAS itemsRC patientsSurgery protocolExpert centersNasogastric tubeEarly mobilizationCarbohydrate loadingImplementing ERASEligibility criteriaCystectomyEnhanced recoverySurgeonsSurgeryAnesthesiologistsPatientsAnesthesiaERAS SocietyExcellence centers
2020
Morbidity and mortality after robot‐assisted radical cystectomy with intracorporeal urinary diversion in octogenarians: results from the European Association of Urology Robotic Urology Section Scientific Working Group
Mortezavi A, Crippa A, Edeling S, Pokupic S, Dell’Oglio P, Montorsi F, D'Hondt F, Mottrie A, Decaestecker K, Wijburg C, Collins J, Kelly J, Tan W, Sridhar A, John H, Canda A, Schwentner C, Rönmark E, Wiklund P, Hosseini A. Morbidity and mortality after robot‐assisted radical cystectomy with intracorporeal urinary diversion in octogenarians: results from the European Association of Urology Robotic Urology Section Scientific Working Group. BJU International 2020, 127: 585-595. PMID: 33058469, PMCID: PMC8246851, DOI: 10.1111/bju.15274.Peer-Reviewed Original ResearchConceptsPatients aged <Intracorporeal urinary diversionCancer-specific mortalityOther-cause mortalityPostoperative complicationsRadical cystectomyMortality rateUrinary diversionBladder cancerOutcomes of patients aged <Predictor of high-grade complicationsHigh-grade complication rateOther-cause mortality ratesRobot-assisted radical cystectomyMultivariate logistic regression analysisClavien-Dindo gradeLaparoscopic radical cystectomyHigh-grade complicationsPostoperative mortality rateMinimally invasive approachTreatment-related risksLogistic regression analysisOCM ratesPostoperative variablesComplication rate
2019
Examining the relationship between complications and perioperative mortality following radical cystectomy: a population‐based analysis
Mossanen M, Krasnow R, Zlatev D, Tan W, Preston M, Trinh Q, Kibel A, Sonpavde G, Schrag D, Chung B, Chang S. Examining the relationship between complications and perioperative mortality following radical cystectomy: a population‐based analysis. BJU International 2019, 124: 40-46. PMID: 30499636, DOI: 10.1111/bju.14636.Peer-Reviewed Original ResearchConceptsRadical cystectomyPerioperative mortalityPostoperative mortalityIncidence of perioperative complicationsTreated with RCPremier Healthcare DatabaseNature of complicationsIncreasing predicted probabilityOdds of mortalityProbability of mortalityReadmission complicationsRenal-relatedSurgical characteristicsPerioperative complicationsBladder cancerPrimary outcomeComplicationsHealthcare databasesPatientsMortalityCystectomyMultivariate regressionReadmissionHospitalisationHospitalMixed‐methods approach to exploring patients’ perspectives on the acceptability of a urinary biomarker test in replacing cystoscopy for bladder cancer surveillance
Tan W, Teo C, Chan D, Heinrich M, Feber A, Sarpong R, Allan J, Williams N, Brew‐Graves C, Ng C, Kelly J, Khetrapal P, ridhar A, Baker H, Ocampo F, Whotton N, Dent K, Pearson S, Hatton J, Newton M, Heeney E, Green K, Evans S, Rogers M, Dann A, Cook J, Cornwell M, Mills R, Knight H, Maher S, Rane A, Thomas S, Reyner S, Vallejera G, Adeniran P, Masood S, Ridgway S, Coulding M, Savill H, Mccormick J, Clark M, Collins G, Jewers K, Keith S, Bowen G, Hargreaves J, Riley K, Srirangam S, Mistry R, Chadwick J, Cocks S, Hull R, Loftus A, Dawson L, Roberts H, Main C, Jain S, Waymont C, Rogers J, Grant A, Carter V, Heap H, Lomas C, Cooke P, Baird Y, Moore S, Greenslade S, Margalef J, Chadbourn I, Harris M, Hicks J, Clitheroe P, Connolly S, Hodgkinson S, Haydock H, inclair A, Storr E, Cogley L, Natale S, Lovegrove W, Smith S, Smith K, Hewitt D, Sriram R, Atkinson K, Royle L, Madine J, MacLean K, Walsh J, Guerdette M, Hill M, Payne D, Power A, Cannon J, Devereaux L, Thompson A, Scarratt L, Hodgkiss T, Johnstone D, Johnson J, Allsop J, Rothwell J, Connolly K, Cherian J, Wardle H, Wilson D, Bayles A, Pelluri S, Pati J, Gherman A, Scott C, Madaan S, Taylor A, Edmunds E, Moore J, Rees A, Williams S, Caddy S, Dukes S, Goffe A, Buckhorn K, Nichols L, Acher P, Baillie K, Middleton K, Proctor C, Cresswell J, Chilvers A, Cain M, Vaux A, Watson D, Bradfield S, Gregory H, Mostafid H, Kehoe L, Drakeley S, Davies A, Williamson L, Krishnan R, Lunt N, Hill P, Burns H, Townley B, Wilkinson L, Wassall H, Hunt J, Holbrook B, Stancombe L, Morrison J, Vankoutrik L, Misra S, Fossey G, Richards A, Mcdonald K, Henderson A, Fennelly R, Tribbeck M, Ames K, Borwell J, Kotze M, Beesley K, Rennie K, Porter T, Gipson A, Piper L, Bailey L, Chrisopoulou A, Slevin K, McCartin F, Warburton H, Hathaway‐Lees S, Whetton K, Delves G, Day A, Bankole T, Broadhead S, Malde S, Oblak M, Ellis D, Bishara S, Barias‐Lara T, Donkov I, Thatcher H, Morris M, Culmsee C, Menzies H, Bartlett C, Cutting C, O'Brien N, Jannapureddy R, Kelkar A, Fitzgerald J, Longhurst S, Worth C, Peracha M, Mzazi S, Poile C, Griffiths L, Cook A, Barber N, Brar N, lty A, Zelhof B, Blades R. Mixed‐methods approach to exploring patients’ perspectives on the acceptability of a urinary biomarker test in replacing cystoscopy for bladder cancer surveillance. BJU International 2019, 124: 408-417. PMID: 30694612, PMCID: PMC6767410, DOI: 10.1111/bju.14690.Peer-Reviewed Original ResearchConceptsMinimally acceptable sensitivityAdverse eventsMixed-methods approachUrine biomarkersUrinary biomarkersProspective multicentre observational studyUrinary biomarker testsUrinary tract symptomsHome to hospitalAssociated with adverse eventsUrinary tract infectionHigh-risk patientsMulticentre observational studySensitivity of cystoscopyBladder cancer surveillanceDiagnosis of cancerSemi-structured interviewsPrevalence of haematuriaPatient experiencePatient perspectivePatients' viewsCancer surveillanceTract infectionsUrine biomarker studiesPatient demographics
2018
Propensity-score-matched comparison of soft tissue surgical margins status between open and robotic-assisted radical cystectomy
Moschini M, Soria F, Mathieu R, Xylinas E, D'Andrea D, Tan W, Kelly J, Simone G, Tuderti G, Meraney A, Krishna S, Konety B, Zamboni S, Baumeister P, Mattei A, Briganti A, Montorsi F, Galucci M, Rink M, Karakiewicz P, Rouprêt M, Aziz A, Perry M, Rowe E, Koupparis A, Kassouf W, Scherr D, Ploussard G, Boorjian S, Sooriakumaran P, Shariat S, Urologists U. Propensity-score-matched comparison of soft tissue surgical margins status between open and robotic-assisted radical cystectomy. Urologic Oncology Seminars And Original Investigations 2018, 37: 179.e1-179.e7. PMID: 30446442, DOI: 10.1016/j.urolonc.2018.10.012.Peer-Reviewed Original ResearchMeSH KeywordsAgedCarcinoma, Transitional CellChemotherapy, AdjuvantCystectomyFemaleFollow-Up StudiesHumansLength of StayLymph Node ExcisionMaleMargins of ExcisionMiddle AgedPostoperative ComplicationsPropensity ScoreRetrospective StudiesRobotic Surgical ProceduresTreatment OutcomeUrinary BladderUrinary Bladder NeoplasmsConceptsSoft tissue surgical marginsRobotic-assisted radical cystectomyOpen radical cystectomyPositive soft tissue surgical marginsRARC groupSoft tissue surgical margin statusRadical cystectomyPropensity-score matchingRARC patientsOpen radical cystectomy groupImpact of surgical techniqueOpen radical cystectomy patientsNon-organ-confinedMultivariate logistic regression analysisOrgan-confined diseaseSurgical margin statusSubgroup of patientsPropensity-score-matched cohortLogistic regression analysisOncologic efficacySurgical marginsPrognostic factorsUrothelial carcinomaMargin statusSurgical technique
2017
Outcomes of Intracorporeal Urinary Diversion after Robot-Assisted Radical Cystectomy: Results from the International Robotic Cystectomy Consortium
Hussein A, May P, Jing Z, Ahmed Y, Wijburg C, Canda A, Dasgupta P, Khan M, Menon M, Peabody J, Hosseini A, Kelly J, Mottrie A, Kaouk J, Hemal A, Wiklund P, Guru K, Collaborators, Wagner A, Saar M, Stockle M, Redorta J, Richstone L, Badani K, Scherr D, Khan H, Gaboardi F, Rha K, Kawa O, Tan W, Schanne F, Polakis V, Weizer A, Maatman T, Pini G, Peak T, Kibel A, Yuh B. Outcomes of Intracorporeal Urinary Diversion after Robot-Assisted Radical Cystectomy: Results from the International Robotic Cystectomy Consortium. Journal Of Urology 2017, 199: 1302-1311. PMID: 29275112, DOI: 10.1016/j.juro.2017.12.045.Peer-Reviewed Original ResearchMeSH KeywordsAgedCystectomyFemaleHumansInternational CooperationMaleMiddle AgedOperative TimeOutcome and Process Assessment, Health CarePatient ReadmissionPostoperative ComplicationsProspective StudiesRetrospective StudiesRisk FactorsRobotic Surgical ProceduresTreatment OutcomeUrinary BladderUrinary Bladder NeoplasmsUrinary DiversionConceptsRobot-assisted radical cystectomyIntracorporeal urinary diversionExtracorporeal urinary diversionShorter operative timeRadical cystectomyHigh grade complicationsUrinary diversionOperative timeGrade complicationsInternational Robotic Cystectomy Consortium databaseInternational Robotic Cystectomy ConsortiumCompare perioperative outcomesLess blood lossMultivariate logistic regression modelPostoperative predictorsBlood lossPerioperative outcomesBlood transfusionCystectomy volumeCystectomyLogistic regression modelsComplicationsConsortium databaseMulti-institutionalPatientsIntracorporeal robot‐assisted radical cystectomy, together with an enhanced recovery programme, improves postoperative outcomes by aggregating marginal gains
Tan W, Tan M, Lamb B, Sridhar A, Mohammed A, Baker H, Nathan S, Briggs T, Tan M, Kelly J. Intracorporeal robot‐assisted radical cystectomy, together with an enhanced recovery programme, improves postoperative outcomes by aggregating marginal gains. BJU International 2017, 121: 632-639. PMID: 29124853, DOI: 10.1111/bju.14073.Peer-Reviewed Original ResearchConceptsLength of hospital stayOpen radical cystectomyRobot-assisted radical cystectomyPeri-operative outcomesRadical cystectomyERAS programmeERAS groupERAS pathwayReadmission ratesOpen radical cystectomy groupAmerican Society of Anesthesiologists scoreIntracorporeal robot-assisted radical cystectomyPeri-operative anaemiaLymph node yieldRadical cystectomy casesClavien-Dindo systemScore-matched cohort of patientsCohort of patientsLevel 1 evidenceImproving postoperative outcomesIntracorporeal urinary diversionBody mass indexScore-matched cohortGastrointestinal-related complicationsPrimary outcome measureA Comprehensive Guide to Perioperative Management and Operative Technique for Robotic Cystectomy with Intracorporeal Urinary Diversion
Tan W, Lamb B, Sridhar A, Briggs T, Kelly J. A Comprehensive Guide to Perioperative Management and Operative Technique for Robotic Cystectomy with Intracorporeal Urinary Diversion. Urologia Journal 2017, 84: 71-78. PMID: 28256704, DOI: 10.5301/uj.5000224.Peer-Reviewed Original ResearchMeSH KeywordsCystectomyHumansIleumPerioperative CarePostoperative ComplicationsPractice Guidelines as TopicRobotic Surgical ProceduresUrinary BladderUrinary Bladder NeoplasmsUrinary DiversionConceptsRobotic-assisted radical cystectomyOpen radical cystectomyConversion to open surgeryReturn to normal functionOncological outcomesRadical cystectomyOpen surgeryUrinary diversionEarly return to normal functionLack of level 1 evidenceShort-term oncological outcomesHigh-volume centresLevel 1 evidenceMinimally invasive approachReduce patient morbidityIntracorporeal urinary diversionEnhanced recovery protocolEarly surgical experienceHigh-volume experienceNormal functionRobotic cystectomyOncologic equivalencePerioperative complicationsPatient selectionInvasive approachBlood Transfusion Requirement and Not Preoperative Anemia Are Associated with Perioperative Complications Following Intracorporeal Robot-Assisted Radical Cystectomy
Tan W, Lamb B, Khetrapal P, Tan M, Tan M, Sridhar A, Cervi E, Rodney S, Busuttil G, Nathan S, Hines J, Shaw G, Mohammed A, Baker H, Briggs T, Klein A, Richards T, Kelly J. Blood Transfusion Requirement and Not Preoperative Anemia Are Associated with Perioperative Complications Following Intracorporeal Robot-Assisted Radical Cystectomy. Journal Of Endourology 2017, 31: 141-148. PMID: 27901350, DOI: 10.1089/end.2016.0730.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnemiaBlood Loss, SurgicalBlood TransfusionCystectomyFemaleHumansMaleMiddle AgedNeoadjuvant TherapyPerioperative PeriodPostoperative ComplicationsPreoperative PeriodPrevalenceProspective StudiesRobotic Surgical ProceduresTransfusion ReactionUrinary Bladder NeoplasmsUrinary DiversionConceptsBlood transfusion requirementsAssociated with perioperative morbidityPreoperative anemiaTransfusion requirementsBlood transfusionComplication ratePerioperative morbidityAssociated with increased surgical riskPresence of preoperative anemiaPrevalence of preoperative anemiaAssociated with increased perioperative morbidityAssociated with perioperative complicationsImpact of preoperative anemiaAssociated with increased complicationsPostoperative blood transfusion rateLower lymph node yieldPostoperative blood transfusion requirementsRobot-assisted radical cystectomyPreoperatively anemic patientsIntraoperative blood transfusionLymph node yieldPostoperative blood transfusionBlood transfusion rateClavien-Dindo systemHospital length of stay
2016
Robotic Assisted Radical Cystectomy with Extracorporeal Urinary Diversion Does Not Show a Benefit over Open Radical Cystectomy: A Systematic Review and Meta-Analysis of Randomised Controlled Trials
Tan W, Khetrapal P, Tan W, Rodney S, Chau M, Kelly J. Robotic Assisted Radical Cystectomy with Extracorporeal Urinary Diversion Does Not Show a Benefit over Open Radical Cystectomy: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. PLOS ONE 2016, 11: e0166221. PMID: 27820855, PMCID: PMC5098822, DOI: 10.1371/journal.pone.0166221.Peer-Reviewed Original ResearchConceptsRobot-assisted radical cystectomyOpen radical cystectomyMeta-analysis of randomised controlled trialsExtracorporeal urinary diversionRandomised controlled trialsRadical cystectomyUrinary diversionPerioperative morbidityBladder cancerLack of Level I evidenceRobot-assisted radical cystectomy groupsPositive lymph node statusOutcomes of robot-assisted radical cystectomySystematic reviewControlled trialsOpen radical cystectomy patientsEfficacy of robot-assisted radical cystectomyInclusion criteriaPositive surgical marginsLymph node statusLymph node yieldMeta-analysisLevel I evidenceIntracorporeal urinary diversionWell-designed trialsIn-depth Critical Analysis of Complications Following Robot-assisted Radical Cystectomy with Intracorporeal Urinary Diversion
Tan W, Lamb B, Tan M, Ahmad I, Sridhar A, Nathan S, Hines J, Shaw G, Briggs T, Kelly J. In-depth Critical Analysis of Complications Following Robot-assisted Radical Cystectomy with Intracorporeal Urinary Diversion. European Urology Focus 2016, 3: 273-279. PMID: 28753745, DOI: 10.1016/j.euf.2016.06.002.Peer-Reviewed Original ResearchConceptsRobot-assisted radical cystectomySurgical complicationsAnalysis of complicationsIntracorporeal urinary diversionRadical cystectomyUrinary diversionClavien-DindoMajor complicationsIleal conduitMultivariate analysisIncidence of surgical complicationsAssociated with major complicationsEarly postoperative morbidityBlood transfusion requirementsUrinary diversion typeMortality of patientsRandomised trial settingMultivariate logistic regressionStandardised reporting criteriaChi-square testPostoperative morbidityTransfusion requirementsPerioperative mortalityComplication rateOpen cystectomy
2015
Robot‐assisted intracorporeal pyramid neobladder
Tan W, Sridhar A, Goldstraw M, Zacharakis E, Nathan S, Hines J, Cathcart P, Briggs T, Kelly J. Robot‐assisted intracorporeal pyramid neobladder. BJU International 2015, 116: 771-779. PMID: 26033321, DOI: 10.1111/bju.13189.Peer-Reviewed Original ResearchConceptsRobot-assisted radical cystectomyMuscle-invasive bladder cancerUrinary tract infectionPostoperative complicationsFunctional outcomesMedian estimated blood lossNight time continenceBilateral pelvic lymphadenectomyEstimated blood lossMedian hospital stayRecurrence-free survivalUpper tract imagingMedian follow-upLate postoperative complicationsEarly postoperative complicationsPort-site herniaUretero-ileal strictureVitamin B12 deficiencyBlocked stentsNeobladder stonePelvic lymphadenectomyOncological outcomesRadical cystectomyOverall survivalBlood loss