2022
Predictive Biomarkers in the Management of Bladder Cancer: Perspectives in an Evolving Therapeutic Landscape
Hensley P, Lobo N, Bree K, Tan W, Gontero P, Williams S, Guo C, Giannarini G, Dyrskjøt L, Kamat A. Predictive Biomarkers in the Management of Bladder Cancer: Perspectives in an Evolving Therapeutic Landscape. Société Internationale D’Urologie Journal 2022, 3: 245-257. DOI: 10.48083/rvzv1144.Peer-Reviewed Original ResearchPredictive biomarkersBladder cancerPredictive biomarkers of therapeutic responseBiomarkers of therapeutic responseManagement of bladder cancerBladder preservation strategiesSequence of therapyMuscle-invasive BCNon-muscle-invasiveEvolving therapeutic landscapeTherapeutic mechanism of actionAdvanced disease stateLikelihood of responseSerum-based biomarkersSystemic therapyTumor gradeTargeted therapyMechanism of actionTherapeutic responseHeterogeneous diseaseUrine-basedPrognostic capacityTherapeutic strategiesTherapeutic landscapeTherapy
2021
Delayed surgery for localised and metastatic renal cell carcinoma: a systematic review and meta-analysis for the COVID-19 pandemic
Chan V, Tan W, Leow J, Tan W, Ong W, Chiu P, Gurung P, Pirola G, Orecchia L, Liew M, Lee H, Wang Y, Chen I, Castellani D, Wroclawski M, Mayor N, Sathianathen N, Braga I, Liu Z, Moon D, Tikkinen K, Kamat A, Meng M, Ficarra V, Giannarini G, Teoh J. Delayed surgery for localised and metastatic renal cell carcinoma: a systematic review and meta-analysis for the COVID-19 pandemic. World Journal Of Urology 2021, 39: 4295-4303. PMID: 34031748, PMCID: PMC8143063, DOI: 10.1007/s00345-021-03734-1.Peer-Reviewed Original ResearchConceptsMetastatic renal cell carcinomaRenal cell carcinomaLocalised RCCDelayed surgeryCytoreductive nephrectomyDeferred CNOverall survivalCell carcinomaTargeted therapyAssociated with worse cancer-specific survivalAssociated with better overall survivalT1a renal cell carcinomaEffect of delaying surgeryDeferred cytoreductive nephrectomyCancer-specific survivalMeta-analysisElective cancer surgeryNewcastle-Ottawa ScaleSystematic reviewComprehensive literature searchUpfront CNOncological effectivenessRisk of biasImmediate surgeryRandomised controlled trials