2022
Comparison of Long-term Outcomes for Young and Healthy Patients with cT1a and cT3a Renal Cell Carcinoma Treated with Partial Nephrectomy
Tan W, Koelker M, Campain N, Cole A, Labban M, Mossanen M, Barod R, Kibel A, Chang S, Bex A, Trinh Q. Comparison of Long-term Outcomes for Young and Healthy Patients with cT1a and cT3a Renal Cell Carcinoma Treated with Partial Nephrectomy. European Urology Focus 2022, 9: 333-335. PMID: 36241545, DOI: 10.1016/j.euf.2022.09.018.Peer-Reviewed Original ResearchConceptsRenal cell carcinomaLocally advanced kidney cancerPositive surgical marginsPartial nephrectomyAdvanced kidney cancerSurgical marginsKidney cancerRate of surgical marginComparison of long-term outcomesNational Cancer DatabaseMedian follow-upPatients aged <Cox proportional-hazards modelLong-term outcomesPresence of tumorCharlson Comorbidity IndexChronic kidney diseaseProportional-hazards modelCT1a tumorsCT1b groupHigher ACMNephron preservationCT stagingSolitary kidneyCell carcinoma
2021
Delayed surgery for localised and metastatic renal cell carcinoma: a systematic review and meta-analysis for the COVID-19 pandemic
Chan V, Tan W, Leow J, Tan W, Ong W, Chiu P, Gurung P, Pirola G, Orecchia L, Liew M, Lee H, Wang Y, Chen I, Castellani D, Wroclawski M, Mayor N, Sathianathen N, Braga I, Liu Z, Moon D, Tikkinen K, Kamat A, Meng M, Ficarra V, Giannarini G, Teoh J. Delayed surgery for localised and metastatic renal cell carcinoma: a systematic review and meta-analysis for the COVID-19 pandemic. World Journal Of Urology 2021, 39: 4295-4303. PMID: 34031748, PMCID: PMC8143063, DOI: 10.1007/s00345-021-03734-1.Peer-Reviewed Original ResearchConceptsMetastatic renal cell carcinomaRenal cell carcinomaLocalised RCCDelayed surgeryCytoreductive nephrectomyDeferred CNOverall survivalCell carcinomaTargeted therapyAssociated with worse cancer-specific survivalAssociated with better overall survivalT1a renal cell carcinomaEffect of delaying surgeryDeferred cytoreductive nephrectomyCancer-specific survivalMeta-analysisElective cancer surgeryNewcastle-Ottawa ScaleSystematic reviewComprehensive literature searchUpfront CNOncological effectivenessRisk of biasImmediate surgeryRandomised controlled trials
2019
Delayed nephrectomy has comparable long-term overall survival to immediate nephrectomy for cT1a renal cell carcinoma: A population-based analysis
Tan W, Trinh Q, Hayn M, Marchese M, Lipsitz S, Nabi J, Kilbridge K, Vale J, Khoubehi B, Kibel A, Sun M, Chang S, Sammon J. Delayed nephrectomy has comparable long-term overall survival to immediate nephrectomy for cT1a renal cell carcinoma: A population-based analysis. Urologic Oncology Seminars And Original Investigations 2019, 38: 74.e13-74.e20. PMID: 31864937, DOI: 10.1016/j.urolonc.2019.11.008.Peer-Reviewed Original ResearchConceptsRenal cell carcinomaCT1a renal cell carcinomaImmediate nephrectomyKaplan-Meier curvesOverall survivalCell carcinomaSurgical resectionRenal massesPatient ageTreatment armsCharlson Comorbidity Index 0Compare OS of patientsLong-term overall survivalInfluence of patient ageCox proportional hazards regression analysisEarly surgical resectionLong-term OSMedian patient ageProportional hazards regression analysisMedian follow-upNational Cancer DatabaseOS of patientsSmall renal massesInverse probabilityRecommended treatment optionPD46-02 DELAYED NEPHRECTOMY HAS COMPARABLE LONG-TERM OVERALL SURVIVAL TO IMMEDIATE NEPHRECTOMY FOR CT1A RENAL CELL CARCINOMA: A RETROSPECTIVE COHORT STUDY
Tan* W, Trinh Q, Hayn M, Marchese M, Lipsitz S, Nabi J, Kilbridge K, Kibel A, Sun M, Chang S, Sammon J. PD46-02 DELAYED NEPHRECTOMY HAS COMPARABLE LONG-TERM OVERALL SURVIVAL TO IMMEDIATE NEPHRECTOMY FOR CT1A RENAL CELL CARCINOMA: A RETROSPECTIVE COHORT STUDY. Journal Of Urology 2019, 201 DOI: 10.1097/01.ju.0000556746.68596.8e.Peer-Reviewed Original Research913 Delayed nephrectomy has comparable long-term overall survival to immediate nephrectomy for cT1a renal cell carcinoma: A retrospective cohort study
Tan W, Trinh Q, Hayn M, Marchese M, Lipsitz S, Nabi J, Kilbridge K, Kibel A, Sun M, Chang S, Sammon J. 913 Delayed nephrectomy has comparable long-term overall survival to immediate nephrectomy for cT1a renal cell carcinoma: A retrospective cohort study. European Urology Open Science 2019, 18: e1235-e1236. DOI: 10.1016/s1569-9056(19)30887-5.Peer-Reviewed Original Research1056 Comparing long-term outcomes following radical and partial nephrectomy for cT1 renal cell carcinoma in young and healthy individuals
Tan W, Berg S, Cole A, Krimphove M, Marchese M, Lipsitz S, Nabi J, Sammon J, Choueiri T, Kibel A, Sun M, Chang S, Trinh Q. 1056 Comparing long-term outcomes following radical and partial nephrectomy for cT1 renal cell carcinoma in young and healthy individuals. European Urology Open Science 2019, 18: e1423-e1424. DOI: 10.1016/s1569-9056(19)31027-9.Peer-Reviewed Original ResearchComparing Long-Term Outcomes Following Radical and Partial Nephrectomy for cT1 Renal Cell Carcinoma in Young and Healthy Individuals
Tan W, Berg S, Cole A, Krimphove M, Marchese M, Lipsitz S, Nabi J, Sammon J, Choueiri T, Kibel A, Sun M, Chang S, Trinh Q. Comparing Long-Term Outcomes Following Radical and Partial Nephrectomy for cT1 Renal Cell Carcinoma in Young and Healthy Individuals. JNCI Cancer Spectrum 2019, 3: pkz003. PMID: 31360891, PMCID: PMC6649692, DOI: 10.1093/jncics/pkz003.Peer-Reviewed Original ResearchLow-stage renal cell carcinomaRenal cell carcinomaTreated with radical nephrectomyInverse probability of treatment weighting adjustmentPartial nephrectomyRadical nephrectomyType of surgeryOverall survivalTreatment weighting adjustmentCell carcinomaClinical stageCompare overall survival of patientsPatients treated with partial nephrectomyLong-term overall survivalCT1 renal cell carcinomaOverall survival of patientsCox proportional hazards regression analysisProportional hazards regression analysisCompare overall survivalNational Cancer DatabaseMedian follow-upSurvival of patientsKaplan-Meier curvesInverse probabilityLong-term outcomes
2015
Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer
Feber A, Arya M, de Winter P, Saqib M, Nigam R, Malone P, Tan W, Rodney S, Lechner M, Freeman A, Jameson C, Muneer A, Beck S, Kelly J. Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer. Clinical Cancer Research 2015, 21: 1196-1206. PMID: 25538261, PMCID: PMC4351916, DOI: 10.1158/1078-0432.ccr-14-1656.Peer-Reviewed Original ResearchMeSH KeywordsCell Transformation, NeoplasticCell Transformation, ViralCluster AnalysisComputational BiologyCpG IslandsDNA MethylationEpigenesis, GeneticGene Expression ProfilingGene Expression Regulation, NeoplasticHumansLymph NodesLymphatic MetastasisMaleNeoplasm MetastasisPapillomaviridaePapillomavirus InfectionsPenile NeoplasmsRepetitive Sequences, Nucleic AcidConceptsHead and neck squamous cell carcinomaCervical squamous cell carcinomaSquamous cell carcinomaPenile cancerHPV statusEpigenetic alterationsCell carcinomaMethylation variable positionsEpi-signatureLymph node metastases markerNeck squamous cell carcinomaHPV-driven malignanciesTumor supressor geneLymph node metastasisMarkers of metastasisPredictors of survivalGenome-wide methylation arrayHPV-induced tumorigenesisHPV infectionRare malignancyOverall survivalQ-MSPNode metastasisTumor tissuesHPV