2021
Neural correlates of extinguished threat recall underlying the commonality between pediatric anxiety and irritability
Tseng WL, Abend R, Gold AL, Brotman MA. Neural correlates of extinguished threat recall underlying the commonality between pediatric anxiety and irritability. Journal Of Affective Disorders 2021, 295: 920-929. PMID: 34706463, PMCID: PMC8554134, DOI: 10.1016/j.jad.2021.08.117.Peer-Reviewed Original ResearchConceptsHigh negative affectivityNegative affectivityThreat appraisalPediatric anxietyAnxiety disordersThreat-safety discriminationWhole-brain activationLinear mixed effects analysisNegative affectivity factorExtinction recallThreat conditioningThreat contingenciesElevated irritabilityNeural correlatesTransdiagnostic sampleGreater prefrontalOccipital activationUnique varianceExplicit recallThreat responsesFMRI paradigmNeural mechanismsTask conditionsAmygdala connectivityMixed effects analysis
2019
Psychiatric comorbid patterns in adults with attention-deficit hyperactivity disorder: Treatment effect and subtypes
Tsai FJ, Tseng WL, Yang LK, Gau SS. Psychiatric comorbid patterns in adults with attention-deficit hyperactivity disorder: Treatment effect and subtypes. PLOS ONE 2019, 14: e0211873. PMID: 30730956, PMCID: PMC6366698, DOI: 10.1371/journal.pone.0211873.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderDrug-naïve adultsChildhood attention-deficit/hyperactivity disorderPsychiatric comorbidityMedication treatmentHigh riskTreatment durationHyperactivity disorderSemi-structured psychiatric interviewCurrent medication treatmentHealthy adult controlsEffects of medicationLonger treatment durationShorter treatment durationAttention deficit hyperactivity disorderADHD inattentive subtypeMore comorbiditiesMedical recordsHealthy controlsMood disordersSleep disordersComorbiditiesPsychiatric interviewLower riskADHD subtypes
2017
Association of Irritability and Anxiety With the Neural Mechanisms of Implicit Face Emotion Processing in Youths With Psychopathology
Stoddard J, Tseng WL, Kim P, Chen G, Yi J, Donahue L, Brotman MA, Towbin KE, Pine DS, Leibenluft E. Association of Irritability and Anxiety With the Neural Mechanisms of Implicit Face Emotion Processing in Youths With Psychopathology. JAMA Psychiatry 2017, 74: 95-103. PMID: 27902832, PMCID: PMC6309540, DOI: 10.1001/jamapsychiatry.2016.3282.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmygdalaAnxiety DisordersArousalAttention Deficit Disorder with HyperactivityBrainChildCross-Sectional StudiesDominance, CerebralEmotionsFacial RecognitionFemaleHumansIrritable MoodMagnetic Resonance ImagingMaleMental DisordersMood DisordersNerve NetPrefrontal CortexPsychopathologyConceptsFunctional magnetic resonance imagingPrefrontal cortex connectivityFace emotionsNeural responsesCortex connectivityMedial prefrontal cortex connectivityAttention-deficit/hyperactivity disorderChild Anxiety Related DisordersThreat-related facesDisruptive Mood DysregulationPathophysiology of irritabilityFace emotion processingAmygdala-medial prefrontal cortex connectivityCross-sectional functional magnetic resonanceAffective Reactivity IndexBrain-behavior relationshipsVentral visual areasAssociations of irritabilityUnique effectsAmygdala functional connectivityAnxiety Related DisordersFunctional magnetic resonanceYouth ages 8Angry facesFearful faces
2013
A Systems Neuroscience Approach to the Pathophysiology of Pediatric Mood and Anxiety Disorders
Tseng WL, Leibenluft E, Brotman MA. A Systems Neuroscience Approach to the Pathophysiology of Pediatric Mood and Anxiety Disorders. 2013, 16: 297-317. PMID: 24281907, PMCID: PMC4482127, DOI: 10.1007/7854_2013_252.Peer-Reviewed Original ResearchConceptsPediatric moodAnxiety disordersFunctional magnetic resonance imaging (fMRI) researchSystems neuroscience approachMagnetic resonance imaging researchNeuroscience approachEmotional dysregulationNeural mechanismsBehavioral findingsCore featuresImaging researchMoodFuture researchPotential novel treatmentDisordersNovel treatmentsResearchBrainFindingsChapterPathophysiologyRelationshipDysregulationAbnormalities