Brain Mechanisms of Attention Orienting Following Frustration: Associations With Irritability and Age in Youths
Tseng WL, Deveney CM, Stoddard J, Kircanski K, Frackman AE, Yi JY, Hsu D, Moroney E, Machlin L, Donahue L, Roule A, Perhamus G, Reynolds RC, Roberson-Nay R, Hettema JM, Towbin KE, Stringaris A, Pine DS, Brotman MA, Leibenluft E. Brain Mechanisms of Attention Orienting Following Frustration: Associations With Irritability and Age in Youths. American Journal Of Psychiatry 2018, 176: 67-76. PMID: 30336704, PMCID: PMC6408218, DOI: 10.1176/appi.ajp.2018.18040491.Peer-Reviewed Original ResearchConceptsLevels of irritabilityWhole-brain activation analysesRegulation of emotionAffective Reactivity IndexInferior frontal gyrusFunctional MRI paradigmDorsolateral prefrontal cortexAnterior cingulate cortexAttention orientingNeural correlatesTransdiagnostic sampleBrain mechanismsFMRI paradigmChildhood irritabilityFrontal gyrusNeural activationChild reportsMotor executionPrefrontal cortexHigh irritabilityCingulate cortexNeural systemsYounger youthNeural activityOlder youth