2024
Irritability in Youths: A Critical Integrative Review
Leibenluft E, Allen L, Althoff R, Brotman M, Burke J, Carlson G, Dickstein D, Dougherty L, Evans S, Kircanski K, Klein D, Malone E, Mazefsky C, Nigg J, Perlman S, Pine D, Roy A, Salum G, Shakeshaft A, Silver J, Stoddard J, Thapar A, Tseng W, Vidal-Ribas P, Wakschlag L, Stringaris A. Irritability in Youths: A Critical Integrative Review. American Journal Of Psychiatry 2024, 181: 275-290. PMID: 38419494, DOI: 10.1176/appi.ajp.20230256.Peer-Reviewed Original ResearchAttention deficit hyperactivity disorderPathophysiology of irritabilityResponse to frustrationParent management trainingTreating psychological problemsDeficit hyperactivity disorderAutism spectrum disorderPrevalence of irritabilityAssociated with impairmentDiverse longitudinal sampleAssociated with increased risk of anxietyRisk of anxietyYouth irritabilityAnxiety disordersTreating irritabilityHyperactivity disorderBehavior problemsSpectrum disorderDevelopmental trajectoriesAssess irritabilityPsychological problemsLongitudinal sampleImpact of cultural contextTranslational findingsSuicide
2023
Autistic Symptoms, Irritability, and Executive Dysfunctions: Symptom Dynamics from Multi-Network Models
Lee K, Gau S, Tseng W. Autistic Symptoms, Irritability, and Executive Dysfunctions: Symptom Dynamics from Multi-Network Models. Journal Of Autism And Developmental Disorders 2023, 54: 3078-3093. PMID: 37453959, DOI: 10.1007/s10803-023-05981-0.Peer-Reviewed Original ResearchAutism spectrum disorderIrritability symptomsExecutive functionExecutive dysfunctionAutistic symptomsCognitive-behavioral mechanismsSocial communication difficultiesRelative importance networksSample of childrenNeurotypical peersElevated irritabilityASD diagnosisSpectrum disorderBridge symptomsCommunication difficultiesTemper outburstsPredictive pathSymptom dynamicsUnaffected siblingsPartial correlationMoodEntire sampleIrritabilitySpecific relationSymptom nodes
2020
Editorial: A Transdiagnostic Symptom Requires a Transdiagnostic Approach: Neural Mechanisms of Pediatric Irritability
Tseng WL. Editorial: A Transdiagnostic Symptom Requires a Transdiagnostic Approach: Neural Mechanisms of Pediatric Irritability. Journal Of The American Academy Of Child & Adolescent Psychiatry 2020, 59: 1327-1329. PMID: 32966839, PMCID: PMC8143431, DOI: 10.1016/j.jaac.2020.09.008.Peer-Reviewed Original ResearchConceptsDisruptive mood dysregulation disorderAttention-deficit/hyperactivity disorderOppositional defiant disorderLong-term impairmentDSM-5 categoriesPediatric disordersHigh suicidalityAnxiety disordersHyperactivity disorderDisordersIrritabilityDefiant disorderHallmark featurePediatric irritabilityTransdiagnostic symptomsNeural mechanismsTransdiagnostic approachAutism spectrum disorderChild psychiatrySpectrum disorderExecutive functions in youths with autism spectrum disorder and their unaffected siblings
Seng GJ, Tseng WL, Chiu YN, Tsai WC, Wu YY, Gau SS. Executive functions in youths with autism spectrum disorder and their unaffected siblings. Psychological Medicine 2020, 51: 2571-2580. PMID: 32349803, DOI: 10.1017/s0033291720001075.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSpatial working memoryExecutive function tasksExecutive functionASD youthWorking memoryFunction tasksCognitive endophenotypesSpatial spanExecutive dysfunctionSpectrum disorderUnaffected siblingsCambridge Neuropsychological Test Automated BatteryAttention-deficit/hyperactivity disorderPotential cognitive endophenotypesExtra-dimensional shiftPlanning/problemVisuospatial working memoryBackward digit recallMain cognitive theoriesStockings of CambridgeDigit span testEvidence of deficitsCognitive theoryDigit recall