2005
Altruism as a reason for participation in clinical trials was independently associated with adherence
Rosenbaum JR, Wells CK, Viscoli CM, Brass LM, Kernan WN, Horwitz RI. Altruism as a reason for participation in clinical trials was independently associated with adherence. Journal Of Clinical Epidemiology 2005, 58: 1109-1114. PMID: 16223653, DOI: 10.1016/j.jclinepi.2005.03.014.Peer-Reviewed Original ResearchConceptsClinical trialsBetter functional statusStudy medicationMedical regimenRecruitment of participantsClinical featuresStroke trialsFunctional statusWomen's EstrogenStratified analysisMultivariable regressionClinical researchEstrogenTrialsAdherenceBaseline featuresSocial supportFurther investigationWomenParticipantsAltruistic reasonsPossible contributionHigh levelsPlaceboMedicationsEstrogen therapy and risk of cognitive decline: Results from the Women's Estrogen for Stroke Trial (WEST)
Viscoli CM, Brass LM, Kernan WN, Sarrel PM, Suissa S, Horwitz RI. Estrogen therapy and risk of cognitive decline: Results from the Women's Estrogen for Stroke Trial (WEST). American Journal Of Obstetrics And Gynecology 2005, 192: 387-393. PMID: 15695976, DOI: 10.1016/j.ajog.2004.08.017.Peer-Reviewed Original ResearchConceptsMini-Mental State ExaminationEstrogen therapyCognitive declineNormal Mini-Mental State ExaminationDouble-blind trialSecondary stroke preventionTransient ischemic attackIschemic attackPostmenopausal womenStroke preventionRecent strokeStroke trialsCerebrovascular diseaseWomen's EstrogenEstradiol-17betaState ExaminationCognitive measuresEstrogenWomenNormal functionDomain measuresLess declineTherapyStrokeRiskDecline in Physical Performance Among Women With a Recent Transient Ischemic Attack or Ischemic Stroke
Kernan WN, Viscoli CM, Brass LM, Gill TM, Sarrel PM, Horwitz RI. Decline in Physical Performance Among Women With a Recent Transient Ischemic Attack or Ischemic Stroke. Stroke 2005, 36: 630-634. PMID: 15677573, DOI: 10.1161/01.str.0000155728.42847.de.Peer-Reviewed Original ResearchConceptsTransient ischemic attackIschemic strokePhysical performance testsPhysical performanceIschemic attackRecent transient ischemic attackRecent ischemic strokeRecurrent neurological eventsAbsence of recurrenceLong-term disabilityEstrogen therapyRecurrent strokePostmenopausal womenNeurological eventsClinical trialsPPT scoresBaseline scoresFunctional independenceStrokeSpecific interventionsSubsequent strokeWomenSustained declineScoresBaseline
2003
Influence of race, clinical, and other socio-demographic features on trial participation
Corbie-Smith G, Viscoli CM, Kernan WN, Brass LM, Sarrel P, Horwitz RI. Influence of race, clinical, and other socio-demographic features on trial participation. Journal Of Clinical Epidemiology 2003, 56: 304-309. PMID: 12767406, DOI: 10.1016/s0895-4356(03)00046-5.Peer-Reviewed Original ResearchConceptsTrial participationPrevious estrogen useClinical trial participationHistory of hysterectomyEstrogen useClinical characteristicsStroke trialsWomen's EstrogenClinical trialsConsent ratesCognitive impairmentSocio-demographic featuresMultivariate modelInfluence of raceHysterectomyEstrogenWomen's decisionsTrialsEthnic groupsImpairmentVisitsWomen
2002
Clinical assessment of function among women with a recent cerebrovascular event: a self-reported versus performance-based measure.
Owens PL, Bradley EH, Horwitz SM, Viscoli CM, Kernan WN, Brass LM, Sarrel PM, Horwitz RI. Clinical assessment of function among women with a recent cerebrovascular event: a self-reported versus performance-based measure. Annals Of Internal Medicine 2002, 136: 802-11. PMID: 12044128, DOI: 10.7326/0003-4819-136-11-200206040-00008.Peer-Reviewed Original ResearchConceptsLong-term health outcomesRecent cerebrovascular eventsLevel of functionCerebrovascular eventsPerformance-based measuresHealth outcomesSelf-reported functional statusTransient ischemic attackProspective cohort studyPhysical performance testsSelf-report measuresIschemic attackPostmenopausal womenBarthel IndexCohort studyNonwhite ethnicityFunctional statusClinical assessmentMost womenHealth measuresClinical settingSubsequent strokeWomenOutcomesStroke
2001
A Clinical Trial of Estrogen-Replacement Therapy after Ischemic Stroke
Viscoli C, Brass L, Kernan W, Sarrel P, Suissa S, Horwitz R. A Clinical Trial of Estrogen-Replacement Therapy after Ischemic Stroke. New England Journal Of Medicine 2001, 345: 1243-1249. PMID: 11680444, DOI: 10.1056/nejmoa010534.Peer-Reviewed Original ResearchConceptsEstrogen replacement therapyEstrogen therapyNonfatal strokePostmenopausal womenIschemic strokeCerebrovascular diseasePlacebo-controlled trialTransient ischemic attackOccurrence of strokeRisk of deathIschemic attackFatal strokeMean followPlacebo groupSecondary preventionEstradiol groupFunctional deficitsClinical trialsObservational studyHigh riskWoman's riskTherapyStrokeWomenDeath
2000
Phenylpropanolamine and the Risk of Hemorrhagic Stroke
Kernan W, Viscoli C, Brass L, Broderick J, Brott T, Feldmann E, Morgenstern L, Wilterdink J, Horwitz R. Phenylpropanolamine and the Risk of Hemorrhagic Stroke. New England Journal Of Medicine 2000, 343: 1826-1832. PMID: 11117973, DOI: 10.1056/nejm200012213432501.Peer-Reviewed Original ResearchConceptsUse of coughHemorrhagic strokeAppetite suppressantsCold remediesControl subjectsOdds ratioIndependent risk factorCase-control studyYears of ageRandom digit dialingIntracerebral hemorrhageCase reportRisk factorsBrain lesionsWomen 18CoughEligibility criteriaStrokeU.S. hospitalsPhenylpropanolamineWomenPatientsMenRiskAssociationBlood Pressure Exceeding National Guidelines Among Women After Stroke
Kernan W, Viscoli C, Brass L, Makuch R, Sarrel P, Horwitz R. Blood Pressure Exceeding National Guidelines Among Women After Stroke. Stroke 2000, 31: 415-419. PMID: 10657415, DOI: 10.1161/01.str.31.2.415.Peer-Reviewed Original ResearchConceptsHistory of hypertensionBlood pressure valuesNational guidelinesBlood pressureFirst examinationTrial of estrogenSecondary stroke preventionTransient ischemic attackBlood pressure controlTreatment of hypertensionProportion of womenIschemic attackSevere hypertensionStroke preventionSecondary preventionDiabetic patientsMean ageHypertensionPatientsPressure valuesPersonal physicianPressure controlSeparate guidelinesStrokeWomen
1994
Gender difference in prognosis after transient cerebral ischemia or minor stroke
Kernan W, Horwitz R, Brass L, Viscoli C. Gender difference in prognosis after transient cerebral ischemia or minor stroke. Journal Of Stroke And Cerebrovascular Diseases 1994, 4: 148-154. PMID: 26486051, DOI: 10.1016/s1052-3057(10)80177-6.Peer-Reviewed Original ResearchTransient ischemic attackTransient cerebral ischemiaCrude relative riskMinor strokeRelative riskIschemic attackCerebral ischemiaCarotid transient ischemic attacksInitial transient ischemic attackRisk of strokeGender differencesEligible patientsComorbid illnessesPrognostic strataStrokeLarger studyStudy outcomesWomenStatistical significanceMenIschemiaPrognosisRiskEffect of genderDeath