Featured Publications
Microneedling as an adjuvant to topical therapies for melasma: A systematic review and meta-analysis
Bailey AJM, Li HO, Tan MG, Cheng W, Dover JS. Microneedling as an adjuvant to topical therapies for melasma: A systematic review and meta-analysis. Journal Of The American Academy Of Dermatology 2021, 86: 797-810. PMID: 33857549, DOI: 10.1016/j.jaad.2021.03.116.Peer-Reviewed Original ResearchConceptsTreatment of melasmaTopical therapyMelasma severitySystematic reviewSerious adverse eventsTopical tranexamic acidEfficacy of microneedlingPlatelet-rich plasmaAdverse eventsTopical interventionsTopical medicationsTranexamic acidProspective studyEligible studiesRadiofrequency microneedlingPRISMA guidelinesTherapyMicroneedlingMelasmaStudy designVitamin CAdjuvantWeeksDepigmenting agentTreatmentAdverse Events Among Emergency Department Patients With Cardiovascular Conditions: A Multicenter Study
Calder LA, Perry J, Yan JW, De Gorter R, Sivilotti MLA, Eagles D, Myslik F, Borgundvaag B, Émond M, McRae AD, Taljaard M, Thiruganasambandamoorthy V, Cheng W, Forster AJ, Stiell IG. Adverse Events Among Emergency Department Patients With Cardiovascular Conditions: A Multicenter Study. Annals Of Emergency Medicine 2021, 77: 561-574. PMID: 33612283, DOI: 10.1016/j.annemergmed.2020.12.012.Peer-Reviewed Original ResearchConceptsAcute heart failureAdverse eventsEmergency department patientsED visitsDepartment patientsHeart failureAtrial fibrillationHealth care provider visitsRecent-onset atrial fibrillationClinical practice guideline adherenceIndex ED visitPractice guideline adherenceAdverse event incidenceProspective cohort studyAdverse event ratesCase summariesQuality improvement opportunitiesFactor themesAdverse event typesCanadian EDsSentinel diagnosesED dischargeProvider visitsAdult patientsCohort studyDoes N-Terminal Pro-B-Type Natriuretic Peptide Improve the Risk Stratification of Emergency Department Patients With Syncope?
Thiruganasambandamoorthy V, McRae AD, Rowe BH, Sivilotti MLA, Mukarram M, Nemnom MJ, Booth RA, Calder LA, Stiell IG, Wells GA, Cheng W, Taljaard M. Does N-Terminal Pro-B-Type Natriuretic Peptide Improve the Risk Stratification of Emergency Department Patients With Syncope? Annals Of Internal Medicine 2020, 172: 648-655. PMID: 32340039, DOI: 10.7326/m19-3515.Peer-Reviewed Original ResearchConceptsCanadian Syncope Risk ScoreSerious adverse eventsPro-B-type natriuretic peptideSerum NT-proBNP concentrationNT-proBNP concentrationsNT-proBNPNatriuretic peptideED patientsN-terminal pro-B-type natriuretic peptideTerminal pro-B-type natriuretic peptidePhysicians Services Incorporated FoundationIndex ED visitNT-proBNP valuesAdult ED patientsProspective cohort studySerum NT-proBNPEmergency department patientsNet reclassification indexHeterogeneity of outcomesAdjudication of outcomesNoncardiac eventsED dispositionAdverse eventsCohort studyComposite outcomeImpact of Timing of Preprocedural Opioids on Adverse Events in Procedural Sedation
Bhatt M, Cheng W, Roback MG, Johnson DW, Taljaard M, Canada T. Impact of Timing of Preprocedural Opioids on Adverse Events in Procedural Sedation. Academic Emergency Medicine 2020, 27: 217-227. PMID: 31894606, DOI: 10.1111/acem.13913.Peer-Reviewed Original ResearchConceptsPositive pressure ventilationOxygen desaturationOpioid administrationAdverse eventsSedation-related adverse eventsCanadian pediatric EDsPrimary risk factorImpact of timingOpioid typeSedation medicationsRespiratory depressionProspective cohortPediatric EDPressure ventilationSedative agentsOriginal cohortProcedural sedationRisk factorsPainful proceduresProcedure typeSedation outcomesMultivariable regressionOpioidsHigh incidenceSedation
2021
Clinical and pharmacokinetic/dynamic outcomes of prolonged infusions of beta-lactam antimicrobials: An overview of systematic reviews
Thabet P, Joshi A, MacDonald E, Hutton B, Cheng W, Stevens A, Kanji S. Clinical and pharmacokinetic/dynamic outcomes of prolonged infusions of beta-lactam antimicrobials: An overview of systematic reviews. PLOS ONE 2021, 16: e0244966. PMID: 33481817, PMCID: PMC7822342, DOI: 10.1371/journal.pone.0244966.Peer-Reviewed Original ResearchConceptsBeta-lactam antimicrobialsClinical cureSystematic reviewProlonged infusionBeta-lactam infusionDefinitive systematic reviewLess sick patientsLength of stayCurrent systematic reviewOverview of reviewsEmergence of resistanceBeta-lactam antibioticsSubsequent systematic reviewsAdverse eventsMicrobiological cureHospitalized patientsIll patientsClinical outcomesIntermittent infusionTreatment failureDATA EXTRACTIONCochrane LibraryMethodologic qualityPROSPERO registryBias assessment