1999
Treatment of bacterial meningitis
Hasbun R, Aronin S, Quagliarello V. Treatment of bacterial meningitis. Comprehensive Therapy 1999, 25: 73-81. PMID: 10091011, DOI: 10.1007/bf02889599.Peer-Reviewed Original ResearchConceptsBacterial meningitisEmergence of penicillinOutcomes of patientsMortality of patientsEffective antibiotic therapyAdjunctive corticosteroidsAntibiotic therapyEpidemiological shiftMeningitisTherapeutic approachesPatientsRoutine useNew antimicrobial agentsPredominant organismAntimicrobial resistanceAntimicrobial agentsGlobal surveillanceTreatmentCorticosteroidsMorbidityTherapyVaccineBetter selectionMortalityInfluenzae
1992
Adjunctive therapy in bacterial meningitis--what make sense?
Quagliarello V, Scheld W. Adjunctive therapy in bacterial meningitis--what make sense? Infectious Agents And Disease 1992, 1: 167-71. PMID: 1365542.Peer-Reviewed Original ResearchConceptsAdjunctive therapyBacterial meningitisCerebrospinal fluidAdjunctive corticosteroidsNeurologic outcomeCSF inflammationAntibiotic therapyBrain edemaCerebral microvasculatureInflammatory cytokinesTherapyMeningitisInflammationPathophysiologyChildrenCorticosteroidsMorbidityEdemaCytokinesMortalityMicrovasculature
1986
Review: Recent Advances in the Pathogenesis and Pathophysiology of Bacterial Meningitis
Quagliarello V, Scheld W. Review: Recent Advances in the Pathogenesis and Pathophysiology of Bacterial Meningitis. The American Journal Of The Medical Sciences 1986, 292: 306-309. PMID: 3535498, DOI: 10.1097/00000441-198611000-00010.Peer-Reviewed Original ResearchConceptsBacterial meningitisHost defenseBactericidal antibiotic therapyInterstitial brain edemaIrreversible neuronal injuryBlood-brain barrier penetrationImpaired host defenseExperimental animal modelsVirulence factorsBrain barrier penetrationSurface virulence factorsBacterial virulence factorsMeningitis developmentPathophysiologic sequelaeMeningeal pathogensNeuronal injuryAntibiotic therapyBrain edemaWorldwide morbidityPathogenetic sequencePathogenetic stepsAnimal modelsMucosal colonizationMeningitisMorbidity