2005
An alternative interpretation of the amyloid Aβ hypothesis with regard to the pathogenesis of Alzheimer's disease
Marchesi VT. An alternative interpretation of the amyloid Aβ hypothesis with regard to the pathogenesis of Alzheimer's disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 9093-9098. PMID: 15967987, PMCID: PMC1166615, DOI: 10.1073/pnas.0503181102.Peer-Reviewed Original ResearchAmino Acid MotifsAmino Acid SequenceAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesCell MembraneCentral Nervous SystemDimerizationEndopeptidasesHumansLipid BilayersMembrane GlycoproteinsMembrane ProteinsModels, BiologicalMolecular Sequence DataNeuronsPeptide HydrolasesPeptidesPresenilin-1Protein BindingSequence Homology, Amino AcidSodium Dodecyl SulfateTemperature
1975
Amino-acid sequence and oligosaccharide attachment sites of human erythrocyte glycophorin.
Tomita M, Marchesi V. Amino-acid sequence and oligosaccharide attachment sites of human erythrocyte glycophorin. Proceedings Of The National Academy Of Sciences Of The United States Of America 1975, 72: 2964-2968. PMID: 1059087, PMCID: PMC432899, DOI: 10.1073/pnas.72.8.2964.Peer-Reviewed Original ResearchConceptsAmino acid sequenceAmino acidsThreonine/serine residuesComplete amino acid sequenceClustering of residuesHydrophilic amino acidsMembrane proteinsSerine residuesTransmembrane orientationOligosaccharide attachment sitesNH2 terminusHuman erythrocyte glycophorinNonpolar residuesEdman degradation techniqueOligosaccharide chainsMajor sialoglycoproteinAttachment sitesHuman erythrocyte membranesResiduesMore complex unitsGlycophorinTerminal segmentGlycosidic bondSequenceUnique structure