1977
Characteristics of blast crisis in chronic granulocytic leukemia.
Rosenthal S, Canellos G, DeVita V, Gralnick H. Characteristics of blast crisis in chronic granulocytic leukemia. Blood 1977, 49: 705-14. PMID: 265737, DOI: 10.1182/blood.v49.5.705.bloodjournal495705.Peer-Reviewed Original ResearchConceptsChronic granulocytic leukemiaBlast crisisExtramedullary leukemiaGranulocytic leukemiaDiagnosis of blast crisisPh1-positive chronic granulocytic leukemiaLymphoblastic groupAcute leukemiaPeripheral bloodHematological criteriaHematological featuresBone marrowLeukemiaMorphological subgroupsPatientsThrombocytopeniaTerminal phaseMarrow
1976
Chemotherapy of the blastic phase of chronic granulocytic leukemia: hypodiploidy and response to therapy.
Canellos G, DeVita V, Whang-Peng J, Chabner B, Schein P, Young R. Chemotherapy of the blastic phase of chronic granulocytic leukemia: hypodiploidy and response to therapy. Blood 1976, 47: 1003-9. PMID: 1064434, DOI: 10.1182/blood.v47.6.1003.bloodjournal4761003.Peer-Reviewed Original ResearchConceptsChromosome-positive chronic granulocytic leukemiaChronic granulocytic leukemiaBlastic phaseComplete remissionPrior splenectomyComplete remittersGranulocytic leukemiaCytosine arabinosidePhiladelphia chromosome-positive chronic granulocytic leukemiaNonsplenectomized groupPrednisone groupPartial remissionMedian survivalElective splenectomyPartial responseSecondary therapyChronic phaseOpposite regimenRemissionSplenectomyVincristinePrednisoneChemotherapyPatientsCell linesSplenectomy in the chronic phase of chronic granulocytic leukemia. Effects in 32 patients.
Ihde D, Canellos G, Schwartz J, DeVita V. Splenectomy in the chronic phase of chronic granulocytic leukemia. Effects in 32 patients. Annals Of Internal Medicine 1976, 84: 17-21. PMID: 1060395, DOI: 10.7326/0003-4819-84-1-17.Peer-Reviewed Original ResearchConceptsChronic phase of chronic granulocytic leukemiaPhase of chronic granulocytic leukemiaChronic granulocytic leukemiaChronic phaseGranulocytic leukemiaPhiladelphia chromosome-positive patientsSurvival of patientsYear of diagnosisChronic phase of diseasePhase of diseaseMedian survivalProphylactic splenectomySplenectomy patientsPlatelet transfusionsElective splenectomyAdequate therapyMassive splenomegalyBlastic transformationEarly diseaseSplenectomyInfluence survivalPatientsStage of illnessLeukemiaSurvival
1975
Meningeal leukemia in the blastic phase of chronic granulocytic leukemia
Schwartz J, Canellos G, Young R, DeVita V. Meningeal leukemia in the blastic phase of chronic granulocytic leukemia. The American Journal Of Medicine 1975, 59: 819-828. PMID: 1059328, DOI: 10.1016/0002-9343(75)90467-2.Peer-Reviewed Original ResearchDibromomannitol in the treatment of chronic granulocytic leukemia: a prospective randomized comparison with busulfan.
Canellos G, Young R, Neiman P, DeVita V. Dibromomannitol in the treatment of chronic granulocytic leukemia: a prospective randomized comparison with busulfan. Blood 1975, 45: 197-203. PMID: 1054609, DOI: 10.1182/blood.v45.2.197.bloodjournal452197.Peer-Reviewed Original ResearchConceptsTreatment of chronic granulocytic leukemiaBusulfan-treated patientsChronic granulocytic leukemiaGranulocytic leukemiaMedian duration of disease controlChronic phase of CGLDuration of disease controlContinuous maintenance therapyElevated leukocyte countTreated with busulfanIncreased skin pigmentationMyelosuppressive actionRemission inductionMaintenance therapyMedian survivalMedian durationBlastic transformationPulmonary fibrosisBusulfanRandomized comparisonChronic phaseLeukocyte countDibromomannitolPatientsCytological dysplasia
1974
Thrombocytosis in Chronic Granulocytic Leukemia: Incidence and Clinical Significance
Mason J, DeVita V, Canellos G. Thrombocytosis in Chronic Granulocytic Leukemia: Incidence and Clinical Significance. Blood 1974, 44: 483-487. PMID: 4528824, DOI: 10.1182/blood.v44.4.483.483.Peer-Reviewed Original ResearchConceptsChronic granulocytic leukemiaPlatelet countGranulocytic leukemiaClinical significanceOccurrence of thrombocytosisElevated platelet countThrombohemorrhagic complicationsUntreated patientsMedian durationShorter survivalBlastic crisisNormal countsPatientsSubsequent courseThrombocytosisLeukemiaCountEntire courseGroupCourseComplicationsClinicIncidenceDiagnosis
1971
Hematologic and Cytogenetic Remission of Blastic Transformation in Chronic Granulocytic Leukemia
Canellos G, DeVita V, Whang-Peng J, Carbone P. Hematologic and Cytogenetic Remission of Blastic Transformation in Chronic Granulocytic Leukemia. Blood 1971, 38: 671-679. PMID: 5288508, DOI: 10.1182/blood.v38.6.671.671.Peer-Reviewed Original ResearchConceptsChronic granulocytic leukemiaBlastic phaseChronic phaseGranulocytic leukemiaBlastic transformationGood partial remissionComplete hematologic remissionCombination of vincristineCell linesResistant cell linesComplete remissionHematologic remissionPartial remissionCytogenetic remissionSubsequent relapseRemissionPatientsFavorable responseDiseaseHypercalcemia in chronic granulocytic leukemia
Haskell C, Devita V, Canellos G. Hypercalcemia in chronic granulocytic leukemia. Cancer 1971, 27: 872-880. PMID: 5280374, DOI: 10.1002/1097-0142(197104)27:4<872::aid-cncr2820270417>3.0.co;2-d.Peer-Reviewed Original Research
1966
Pseudohyperkalemia Due to Release of Potassium from White Blood Cells during Clotting
Bronson W, DeVita V, Carbone P, Cotlove E. Pseudohyperkalemia Due to Release of Potassium from White Blood Cells during Clotting. New England Journal Of Medicine 1966, 274: 369-375. PMID: 5216594, DOI: 10.1056/nejm196602172740702.Peer-Reviewed Original Research