1982
Histologic progression in non-Hodgkin's lymphoma.
Hubbard S, Chabner B, DeVita V, Simon R, Berard C, Jones R, Garvin A, Canellos G, Osborne C, Young R. Histologic progression in non-Hodgkin's lymphoma. Blood 1982, 59: 258-64. PMID: 7034812, DOI: 10.1182/blood.v59.2.258.bloodjournal592258.Peer-Reviewed Original ResearchAdultBiopsyFemaleHumansLymph NodesLymphomaLymphoma, FollicularLymphoma, Large B-Cell, DiffuseMaleMiddle AgedTime Factors
1980
Non-Hodgkin's lymphomas in leukemic phase: Clinicopathologic correlations
Come S, Jaffe E, Andersen J, Mann R, Johnson B, DeVita V, Young R. Non-Hodgkin's lymphomas in leukemic phase: Clinicopathologic correlations. The American Journal Of Medicine 1980, 69: 667-674. PMID: 7001897, DOI: 10.1016/0002-9343(80)90416-7.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedChildChild, PreschoolHumansLeukemia, LymphoidLymph NodesLymphocytesLymphoma, Large B-Cell, DiffuseLymphoma, Non-HodgkinMiddle AgedPrognosisConceptsPeripheral blood involvementBlood involvementHistologic subtypeLeukemic phaseAdult lymphoblastic lymphomaDiffuse large cell lymphomaNon-Hodgkin lymphomaLarge cell lymphomaHomogeneous clinical pictureTypes of NHLLymphoblastic lymphomaRappaport classificationClinical pictureClinicopathologic entityHodgkin's lymphomaNodular lymphomaUnresponsive diseaseClinicopathologic correlationLymphocytic lymphomaClinical subtypesLeukemic conversionCell lymphomaCytologic featuresHigh riskPredominant cellsThe Rappaport classification of non-Hodgkin's lymphomas: a closer look using other proposed classifications.
Garvin A, Simon R, Young R, DeVita V, Berard C. The Rappaport classification of non-Hodgkin's lymphomas: a closer look using other proposed classifications. Seminars In Oncology 1980, 7: 234-43. PMID: 6998002.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsFemaleHumansLymphomaLymphoma, FollicularLymphoma, Large B-Cell, DiffuseLymphoma, Non-HodgkinMaleMiddle AgedConceptsLukes-Collins systemNon-Hodgkin's lymphomaLukes-CollinsClassification of non-Hodgkin's lymphomasClinical management of patientsAggressive combination chemotherapyDiffuse histiocytic lymphomaHomogeneous group of patientsManagement of patientsGroup of patientsB symptomsLymphocytic lymphomaCentroblastic-centrocyticCombination chemotherapyDiffuse lymphomaLymphoblastic lymphomaPlasmacytoid differentiationKiel classificationRappaport classificationNodular lymphomaHistiocytic lymphomaRetrospective reviewFollicular patternClinicopathologic entityYounger patientsNodular histiocytic lymphoma: an aggressive nodular lymphoma with potential for prolonged disease-free survival.
Osborne C, Norton L, Young R, Garvin A, Simon R, Berard C, Hubbard S, DeVita V. Nodular histiocytic lymphoma: an aggressive nodular lymphoma with potential for prolonged disease-free survival. Blood 1980, 56: 98-103. PMID: 6992889, DOI: 10.1182/blood.v56.1.98.bloodjournal56198.Peer-Reviewed Original ResearchMeSH KeywordsHumansLymph NodesLymphomaLymphoma, Large B-Cell, DiffuseNeoplasm StagingRetrospective StudiesTime FactorsConceptsNodular histiocytic lymphomasDiffuse histiocytic lymphomaHistiocytic lymphomaNodular lymphomaPathological stageProlonged disease-free survivalNatural historyLymph node biopsyNon-Hodgkin's lymphomaDisease-free survivalSubtypes of lymphomaTreated with cyclophosphamideLymph node examinationLymph node histologyGroup of patientsLong-term survivorsCombination chemotherapyNode biopsyNode examinationLiver involvementNode histologyLymphomaTherapeutic strategiesPatientsLymphPersistent immunologic abnormalities in long-term survivors of advanced Hodgkin's disease.
Fisher R, DeVita V, Bostick F, Vanhaelen C, Howser D, Hubbard S, Young R. Persistent immunologic abnormalities in long-term survivors of advanced Hodgkin's disease. Annals Of Internal Medicine 1980, 92: 595-9. PMID: 6992672, DOI: 10.7326/0003-4819-92-5-595.Peer-Reviewed Original ResearchConceptsLong-term survivorsMitogen-induced lymphocyte proliferationPersistent immunologic abnormalitiesHodgkin's diseaseImmunologic abnormalitiesE rosettesLymphocyte proliferationAdvanced diffuse histiocytic lymphomaDepressed cellular immunityAdvanced Hodgkin's diseaseDisease-free intervalDiffuse histiocytic lymphomaB cell numbersNormal control subjectsComparable chemotherapyMOPP chemotherapyUntreated patientsCellular immunityControl subjectsHistiocytic lymphomaImmunologic studiesNormal rangeControl populationChemotherapyAbnormalities
1979
A comparison between combination chemotherapy and total body irradiation plus combination chemotherapy in non‐Hodgkin's lymphoma
Brereton H, Young R, Longo D, Kirkland L, Berard C, Jaffe E, Devita V, Johnson R. A comparison between combination chemotherapy and total body irradiation plus combination chemotherapy in non‐Hodgkin's lymphoma. Cancer 1979, 43: 2227-2231. PMID: 378350, DOI: 10.1002/1097-0142(197906)43:6<2227::aid-cncr2820430611>3.0.co;2-j.Peer-Reviewed Original Research
1978
Clinical Relevance of the Histopathological Subclassification of Diffuse Histiocytic Lymphoma
Strauchen J, Young R, Devita V, Anderson T, Fantone J, Berard C. Clinical Relevance of the Histopathological Subclassification of Diffuse Histiocytic Lymphoma. New England Journal Of Medicine 1978, 299: 1382-1387. PMID: 362206, DOI: 10.1056/nejm197812212992503.Peer-Reviewed Original ResearchConceptsComplete response rateDiffuse histiocytic lymphomaHistopathological subclassificationExcellent prognosisIntermediate prognosisBetter prognosisPoor prognosisHistiocytic lymphomaMorphologic subclassificationHistopathological categoriesHeterogeneous diseaseClinical relevancePrognosisResponse rateMorphologic featuresLymphomaChemotherapyPatientsTumorsSubclassificationSurvivalDifferencesDiseaseSequential nonsurgical and surgical staging of non‐Hodgkin's lymphoma
Chabner B, Johnson R, Young R, Canellos G, Hubbard S, Johnson S, Devita V. Sequential nonsurgical and surgical staging of non‐Hodgkin's lymphoma. Cancer 1978, 42: 922-925. PMID: 150938, DOI: 10.1002/1097-0142(197808)42:2+<922::aid-cncr2820420714>3.0.co;2-9.Peer-Reviewed Original ResearchMeSH KeywordsBiopsyBone Marrow ExaminationDiagnostic ErrorsFemaleHumansLaparoscopyLaparotomyLiver NeoplasmsLymphographyLymphomaLymphoma, Large B-Cell, DiffuseLymphoma, Non-HodgkinMaleNeoplasm StagingDiffuse histiocytic lymphoma involving the gastrointestinal tract
Hande K, Fisher R, Devita V, Chabner B, Young R. Diffuse histiocytic lymphoma involving the gastrointestinal tract. Cancer 1978, 41: 1984-1989. PMID: 348299, DOI: 10.1002/1097-0142(197805)41:5<1984::aid-cncr2820410544>3.0.co;2-8.Peer-Reviewed Original ResearchConceptsDiffuse histiocytic lymphomaBowel perforationComplete remissionSurgical resectionHistiocytic lymphomaGastrointestinal tractActive chemotherapeutic regimensMassive intestinal hemorrhageMajority of patientsResults of stagingRigorous stagingGastrointestinal lymphomaSystemic chemotherapySystemic therapyBowel lesionsChemotherapeutic regimensIntestinal hemorrhageDrug therapyRadiation therapyPatientsTumor resistanceLymphomaTherapyRelative rarityWidespread disease
1977
Advanced lymphocytic lymphoma: randomized comparisons of chemotherapy and radiotherapy, alone or in combination.
Young R, Johnson R, Canellos G, Chabner B, Brereton H, Berard C, DeVita V. Advanced lymphocytic lymphoma: randomized comparisons of chemotherapy and radiotherapy, alone or in combination. Journal Of The National Cancer Institute 1977, 61: 1153-9. PMID: 332349.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBlood PlateletsClinical Trials as TopicCyclophosphamideDrug Therapy, CombinationFemaleHumansLeukocytesLymphoma, Large B-Cell, DiffuseLymphoma, Non-HodgkinMaleMiddle AgedNeoplasm StagingPrednisoneProcarbazineProspective StudiesRadiation DosageRadiation InjuriesRemission, SpontaneousTime FactorsVincristineConceptsHigher overall response rateCyclic combination chemotherapyOverall response rateCombination chemotherapyMedian followupResponse rateSimilar complete remission ratesRelapse-free survival rateComparison of chemotherapyMonths median followupComplete remission rateOverall median survivalDisease-free survivalTotal body irradiationNodular mixed lymphomaInduction regimenInduction therapyComplete remissionMedian survivalProspective trialRemission rateUntreated patientsMixed lymphomaMalignant lymphomaNodular lymphomaCombination chemotherapy in non-Hodgkin's lymphoma: results of long-term followup.
Anderson T, Bender R, Fisher R, DeVita V, Chabner B, Berard C, Norton L, Young R. Combination chemotherapy in non-Hodgkin's lymphoma: results of long-term followup. Journal Of The National Cancer Institute 1977, 61: 1057-66. PMID: 71205.Peer-Reviewed Original ResearchAdolescentAdultAgedBleomycinChildClinical Trials as TopicCyclophosphamideDoxorubicinDrug Administration ScheduleDrug Therapy, CombinationFollow-Up StudiesHumansLymphomaLymphoma, Large B-Cell, DiffuseLymphoma, Non-HodgkinMechlorethamineMiddle AgedNeoplasm StagingPrednisoneProcarbazineRemission, SpontaneousTime FactorsVincristineProceedings of the Conference on non-Hodgkin's lymphomas: summary of symposium.
DeVita V. Proceedings of the Conference on non-Hodgkin's lymphomas: summary of symposium. Journal Of The National Cancer Institute 1977, 61: 1223-7. PMID: 332356.Peer-Reviewed Original ResearchPrognostic factors for advanced diffuse histiocytic lymphoma following treatment with combination chemotherapy
Fisher R, DeVita V, Johnson B, Simon R, Young R. Prognostic factors for advanced diffuse histiocytic lymphoma following treatment with combination chemotherapy. The American Journal Of Medicine 1977, 63: 177-182. PMID: 70170, DOI: 10.1016/0002-9343(77)90230-3.Peer-Reviewed Original Research
1976
Bleomycin, adriamycin, cyclophosphamide, vincristine, and prednisone (BACOP) combination chemotherapy in the treatment of advanced diffuse histiocytic lymphoma.
Schein P, DeVita V, Hubbard S, Chabner B, Canellos G, Berard C, Young R. Bleomycin, adriamycin, cyclophosphamide, vincristine, and prednisone (BACOP) combination chemotherapy in the treatment of advanced diffuse histiocytic lymphoma. Annals Of Internal Medicine 1976, 85: 417-22. PMID: 61732, DOI: 10.7326/0003-4819-85-4-417.Peer-Reviewed Original ResearchConceptsHistiocytic lymphomaAdvanced diffuse histiocytic lymphomaExtended disease-free survivalMixed histiocytic-lymphocytic lymphomaNew combination chemotherapy programHistiocytic-lymphocytic lymphomaPrednisone combination chemotherapyCompletion of therapyDiscontinuation of treatmentCombination chemotherapy programsDisease-free survivalDiffuse histiocytic lymphomaBone marrow functionMyelosuppressive phaseComplete remissionMedian durationChemotherapy programCombination chemotherapyComplete responseMarrow functionTumor recurrenceTreatment cyclesFatal diseasePatientsLymphomaSequential nonsurgical and surgical staging of non-Hodgkin's lymphoma.
Chabner B, Johnson R, Young R, Canellos G, Hubbard S, Johnson S, DeVita V. Sequential nonsurgical and surgical staging of non-Hodgkin's lymphoma. Annals Of Internal Medicine 1976, 85: 149-54. PMID: 782309, DOI: 10.7326/0003-4819-85-2-149.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiopsy, NeedleFemaleHumansLaparotomyLiver NeoplasmsLymphatic MetastasisLymphographyLymphomaLymphoma, Large B-Cell, DiffuseLymphoma, Non-HodgkinMaleMiddle AgedProspective StudiesConceptsNon-Hodgkin's lymphomaStaging of non-Hodgkin's lymphomaStaging laparotomyLiver biopsyStage III or stage IV diseasePresence of disseminated diseaseDiagnostic proceduresStage IV diseaseBone marrow biopsyPercutaneous liver biopsySequence of diagnostic proceduresNegative lymphangiogramIV diseaseSurgical stagingDisseminated diseaseConsecutive patientsLocalized diseaseNodular lymphomaPositive lymphangiogramHistiocytic lymphomaStaging procedureLymphomaStage IPatientsNonsurgical proceduresCentral nervous system complications in patients with diffuse histiocytic and undifferentiated lymphoma: leukemia revisited.
Bunn P, Schein P, Banks P, DeVita V. Central nervous system complications in patients with diffuse histiocytic and undifferentiated lymphoma: leukemia revisited. Blood 1976, 47: 3-10. PMID: 1106798, DOI: 10.1182/blood.v47.1.3.bloodjournal4713.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBrainCentral Nervous System DiseasesCerebrospinal FluidFemaleHumansLymphomaLymphoma, Large B-Cell, DiffuseMaleMeningesMiddle AgedConceptsLeptomeningeal lymphomaCentral nervous systemHistologic types of non-Hodgkin's lymphomasProgression of systemic diseaseCentral nervous system complicationsCentral nervous system therapyProphylactic CNS therapySite of relapseBone marrow involvementNon-Hodgkin's lymphomaIntrathecal drug administrationPatient's clinical courseCerebrospinal fluid cytologyResponse to therapyNervous system complicationsNervous system therapyBone marrow cavityUndifferentiated lymphomaMarrow involvementClinical remissionSystemic therapyCNS therapyClinical courseHistological typeSystemic complications
1975
Results of combination chemotherapy of non-Hodgkin's lymphoma.
Schein P, Chabner B, Canellos G, Young R, Berard C, DeVita V. Results of combination chemotherapy of non-Hodgkin's lymphoma. British Journal Of Cancer. Supplement 1975, 2: 465-73. PMID: 1101932, PMCID: PMC2149606.Peer-Reviewed Original ResearchConceptsComplete remissionHodgkin's lymphomaCombination chemotherapyHistological subgroupsLymphocytic lymphomaMonths of treatmentDiffuse histiocytic lymphomaMOPP chemotherapyMedian durationLate recurrenceLymph nodesNodular histologyHistiocytic lymphomaRemissionExtended survivalBone marrowClinical validityLymphomaAdvanced stageChemotherapyPatientsRelapseInitial siteMonthsSurvivalNon‐Hodgkin's lymphoma: Patterns of relapse from complete remission after combination chemotherapy
Schein P, Chabner B, Canellos G, Young R, Devita V. Non‐Hodgkin's lymphoma: Patterns of relapse from complete remission after combination chemotherapy. Cancer 1975, 35: 354-357. PMID: 1089470, DOI: 10.1002/1097-0142(197502)35:2<354::aid-cncr2820350209>3.0.co;2-2.Peer-Reviewed Original ResearchConceptsDiffuse histiocytic lymphomaComplete remissionLymphocytic lymphomaCombination chemotherapyHistiocytic lymphomaExtended disease-free survivalDisease-free survivalPatterns of relapseMonths of treatmentMaintenance chemotherapyRemission inductionLymph nodesLate recurrenceHistologic subgroupsHodgkin's lymphomaRemissionBone marrowLymphomaChemotherapyAggressive attemptsPatientsRelapseInitial siteTreatmentRecurrenceADVANCED DIFFUSE HISTIOCYTIC LYMPHOMA, A POTENTIALLY CURABLE DISEASE RESULTS WITH COMBINATION CHEMOTHERAPY
Devita V, Canellos G, Chabner B, Schein P, Hubbard S, Young R. ADVANCED DIFFUSE HISTIOCYTIC LYMPHOMA, A POTENTIALLY CURABLE DISEASE RESULTS WITH COMBINATION CHEMOTHERAPY. The Lancet 1975, 305: 248-250. PMID: 46388, DOI: 10.1016/s0140-6736(75)91142-3.Peer-Reviewed Original ResearchConceptsAdvanced diffuse histiocytic lymphomaDiffuse histiocytic lymphomaCombination chemotherapyHistiocytic lymphomaPatients treated with radiotherapyTreated with combination chemotherapySurvival free of diseaseEvidence of tumorFree of diseaseRecurrence of tumorReticulum-cell sarcomaDefinition of cureModern drug treatmentComplete remissionPartial respondersNon-respondersDrug treatmentPatientsSurvival dataLymphomaRemissionChemotherapyNitrogen mustardTumorTreatmentReversible penile calcifications associated with bleomycin (NSC-125066)-induced pulmonary toxicity.
Ihde D, Gormley P, Francis R, DeVita V. Reversible penile calcifications associated with bleomycin (NSC-125066)-induced pulmonary toxicity. Cancer Chemotherapy Reports 1975, 59: 1039-41. PMID: 54214.Peer-Reviewed Original Research