1976
Combination chemotherapy for advanced breast cancer: response and effect on survival.
Canellos G, DeVita V, Gold G, Chabner B, Schein P, Young R. Combination chemotherapy for advanced breast cancer: response and effect on survival. Annals Of Internal Medicine 1976, 84: 389-92. PMID: 1259283, DOI: 10.7326/0003-4819-84-4-389.Peer-Reviewed Original ResearchConceptsMedian survivalBreast cancerFunctional liver impairmentPrevious cytotoxic therapyAdvanced breast cancerMetastatic breast cancerHormonal therapyLiver impairmentMetastatic diseasePartial responseCombination chemotherapyComplete responseNodal metastasisCytotoxic therapyEndocrine ablationPatientsFourteenth daySoft tissueEighth daySurvivalTherapyCancerMonthsDaysResponsive sites
1974
Cyclical Combination Chemotherapy for Advanced Breast Carcinoma
Canellos G, Devita V, Gold G, Chabner B, Schein P, Young R. Cyclical Combination Chemotherapy for Advanced Breast Carcinoma. The BMJ 1974, 1: 218. PMID: 4818162, PMCID: PMC1633086, DOI: 10.1136/bmj.1.5901.218.Peer-Reviewed Original ResearchConceptsMedian survivalMetastatic lesionsAdvanced metastatic breast cancerCyclical combination chemotherapyOverall median durationAdvanced breast carcinomaBone marrow involvementMetastatic breast cancerMetastasis-free intervalSoft tissueExtensive radiotherapyPrevious chemotherapyComplete remissionHaematological toxicityHormonal therapyLiver dysfunctionMarrow involvementMedian durationCombination chemotherapyEndocrine ablationBreast carcinomaBreast cancerPatientsMonthly cyclesChemotherapy