1991
Superiority of ProMACE-CytaBOM over ProMACE-MOPP in the treatment of advanced diffuse aggressive lymphoma: results of a prospective randomized trial.
Longo D, DeVita V, Duffey P, Wesley M, Ihde D, Hubbard S, Gilliom M, Jaffe E, Cossman J, Fisher R. Superiority of ProMACE-CytaBOM over ProMACE-MOPP in the treatment of advanced diffuse aggressive lymphoma: results of a prospective randomized trial. Journal Of Clinical Oncology 1991, 9: 25-38. PMID: 1702144, DOI: 10.1200/jco.1991.9.1.25.Peer-Reviewed Original ResearchConceptsDaily days 1ProMACE-MOPPComplete remissionProMACE-CytaBOMDay 1Day 8Complete respondersSmall noncleaved-cell lymphomaCo-trimoxazole prophylaxisComplete response rateDouble-strength tabletProMACE-CytaBOM regimenTreatment-related causesTreatment-related mortalityPneumocystis carinii pneumoniaDiffuse aggressive lymphomasPeriod of treatmentDay 1 treatmentCombination chemotherapyAggressive lymphomaCarinii pneumoniaMalignant lymphomaEffective treatmentPatientsResponse rate
1982
Malignant lymphoma I. The histology and staging of 473 patients at the national cancer institute
Anderson T, Chabner B, Young R, Berard C, Garvin AJ, Simon R, Devita V. Malignant lymphoma I. The histology and staging of 473 patients at the national cancer institute. Cancer 1982, 50: 2699-2707. PMID: 7139563, DOI: 10.1002/1097-0142(19821215)50:12<2699::aid-cncr2820501202>3.0.co;2-a.Peer-Reviewed Original ResearchConceptsDiffuse lymphoma patientsNodular lymphoma patientsLymphoma patientsNational Cancer InstituteDiffuse lymphomaCancer InstituteCS III diseaseAdvanced-stage patientsBurkitt's lymphoma patientsExtranodal diseaseClinical stagingConsecutive patientsMedian agePathologic stagingStage patientsRetrospective reviewMalignant lymphomaNodular lymphomaSystemic symptomsRappaport systemPathologic materialBurkitt's lymphomaPatientsLymphomaDisease
1981
Natural history of malignant lymphomas with divergent histologies at staging evaluation
Fisher R, Jones R, Devita V, Simon R, Garvin A, Berard C, Young R. Natural history of malignant lymphomas with divergent histologies at staging evaluation. Cancer 1981, 47: 2022-2025. PMID: 7226096, DOI: 10.1002/1097-0142(19810415)47:8<2022::aid-cncr2820470820>3.0.co;2-v.Peer-Reviewed Original ResearchConceptsDifferent histologic diagnosesHistologic diagnosisNatural historyStaging evaluationMalignant lymphomaDiffuse patternNodular patternTissue sitesComplete response rateInitial staging evaluationNational Cancer InstituteMultiple tissue sitesMedian survivalMedical recordsCancer InstituteDivergent histologyPatientsBiopsyResponse ratePlanning treatmentUnique natural historyDiagnosisMonthsLymphomaTreatmentResolution of longstanding protein-losing enteropathy in a patient with intestinal lymphangiectasia after treatment for malignant lymphoma
Broder S, Callihan T, Jaffe E, DeVita V, Strober W, Bartter F, Waldmann T. Resolution of longstanding protein-losing enteropathy in a patient with intestinal lymphangiectasia after treatment for malignant lymphoma. Gastroenterology 1981, 80: 166-168. PMID: 7450403, DOI: 10.1016/0016-5085(81)90208-0.Peer-Reviewed Original ResearchConceptsIntestinal lymphangiectasiaCombination chemotherapyMalignant lymphomaUndifferentiated malignant lymphomaSystemic combination chemotherapyGastrointestinal protein lossProtein lossB-cell originSerum protein concentrationMonoclonal B-cell originGastrointestinal symptomsRecurrent vomitingMassive edemaIntestinal lymphangiectasisIntestinal lymphaticsGastrointestinal tractNeoplastic cellsPatientsLymphomaLymphangiectasiaInitial evaluationYr durationChemotherapyEdemaDisease
1979
Central nervous system complications of non-Hodgkin's lymphoma The potential role for prophylactic therapy
Young R, Howser D, Anderson T, Fisher R, Jaffe E, DeVita V. Central nervous system complications of non-Hodgkin's lymphoma The potential role for prophylactic therapy. The American Journal Of Medicine 1979, 66: 435-443. PMID: 433950, DOI: 10.1016/0002-9343(79)91065-9.Peer-Reviewed Original ResearchConceptsCentral nervous systemCNS diseaseHodgkin's lymphomaCentral nervous system complicationsNervous system complicationsWhole-brain irradiationGood clinical responseBone marrow involvementTime of diagnosisGroup of patientsAdvanced diseaseBrain irradiationClinical remissionCNS prophylaxisIntrathecal chemotherapyLymphomatous meningitisProphylactic therapyClinical responseMarrow involvementPositive cytologyMalignant lymphomaSystem complicationsLumbar punctureNodular lymphomaRisk factors
1978
Chemotherapy (cyclophosphamide, vincristine, and prednisone) versus radiotherapy (total body irradiation) for stage III-IV poorly differentiated lymphocytic lymphoma.
Johnson R, Canellos G, Young R, Chabner B, DeVita V. Chemotherapy (cyclophosphamide, vincristine, and prednisone) versus radiotherapy (total body irradiation) for stage III-IV poorly differentiated lymphocytic lymphoma. Journal Of The National Cancer Institute 1978, 62: 321-5. PMID: 580598.Peer-Reviewed Original ResearchConceptsTotal body irradiationTotal body irradiation patientsEvaluate new therapeutic approachesSurvival rateStage III-IVCandida sepsisDurable remissionsLymphocytic lymphomaBody irradiationMalignant lymphomaSevere granulocytopeniaMyeloproliferative disordersLate complicationsIII-IVChemotherapy complicationsInduction treatmentSurvival advantageNeurotoxic reactionsTherapeutic approachesLymphomaChemotherapyPatientsComplicationsRadiotherapySurvival
1977
Advanced lymphocytic lymphoma: randomized comparisons of chemotherapy and radiotherapy, alone or in combination.
Young R, Johnson R, Canellos G, Chabner B, Brereton H, Berard C, DeVita V. Advanced lymphocytic lymphoma: randomized comparisons of chemotherapy and radiotherapy, alone or in combination. Journal Of The National Cancer Institute 1977, 61: 1153-9. PMID: 332349.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBlood PlateletsClinical Trials as TopicCyclophosphamideDrug Therapy, CombinationFemaleHumansLeukocytesLymphoma, Large B-Cell, DiffuseLymphoma, Non-HodgkinMaleMiddle AgedNeoplasm StagingPrednisoneProcarbazineProspective StudiesRadiation DosageRadiation InjuriesRemission, SpontaneousTime FactorsVincristineConceptsHigher overall response rateCyclic combination chemotherapyOverall response rateCombination chemotherapyMedian followupResponse rateSimilar complete remission ratesRelapse-free survival rateComparison of chemotherapyMonths median followupComplete remission rateOverall median survivalDisease-free survivalTotal body irradiationNodular mixed lymphomaInduction regimenInduction therapyComplete remissionMedian survivalProspective trialRemission rateUntreated patientsMixed lymphomaMalignant lymphomaNodular lymphoma
1975
Osteonecrosis of the femoral head in patients with lymphoma treated with intermittent combination chemotherapy (including corticosteroids)
Ihde D, Devita V. Osteonecrosis of the femoral head in patients with lymphoma treated with intermittent combination chemotherapy (including corticosteroids). Cancer 1975, 36: 1585-1588. PMID: 1192349, DOI: 10.1002/1097-0142(197511)36:5<1585::aid-cncr2820360508>3.0.co;2-d.Peer-Reviewed Original ResearchConceptsCombination chemotherapyFemoral headHigh-dose prednisoneIntermittent combination chemotherapyWeeks of therapyInitiation of therapyLong-term complicationsNecrosis of boneSteroid administrationAdult patientsMalignant lymphomaPatientsChemotherapyLymphomaOsteonecrosisComplicationsTherapyPrednisoneVincristineNecrosisHeadAdministrationWeeksMonthsAmerican Burkitt's lymphoma: A clinicopathologic study of 30 cases II. Pathologic correlations
Banks P, Arseneau J, Gralnick H, Canellos G, DeVita V, Berard C. American Burkitt's lymphoma: A clinicopathologic study of 30 cases II. Pathologic correlations. The American Journal Of Medicine 1975, 58: 322-329. PMID: 163581, DOI: 10.1016/0002-9343(75)90598-7.Peer-Reviewed Original ResearchMeSH KeywordsAbdomenAdolescentAdultAutopsyBiopsyBone MarrowBurkitt LymphomaChildChild, PreschoolCytoplasmFemaleHumansInclusion BodiesIntestinal NeoplasmsIntestine, SmallLiverLymphatic MetastasisMacrophagesMaleMandibular NeoplasmsMaxillary NeoplasmsNorth AmericaOvarian NeoplasmsSouth AmericaUnited StatesConceptsMonths of therapyBone marrow involvementOlder median ageCentral nervous systemInitial therapyClinicopathologic studyMarrow involvementBurkitt's typeMedian ageMultiorgan involvementMalignant lymphomaShorter survivalMassive infiltrationAmerican patientsPelvic sitesPathologic correlationDiffuse necrosisHistologic appearanceTherapeutic implicationsOrgan sitesBone marrowNervous systemEndemic regionsTumor cellsLymphomaPatterns of involvement with malignant lymphoma and implications for treatment decision making.
Johnson R, DeVita V, Kun L, Chabner B, Chretien P, Berard C, Johnson S. Patterns of involvement with malignant lymphoma and implications for treatment decision making. British Journal Of Cancer. Supplement 1975, 2: 237-41. PMID: 1182071, PMCID: PMC2149575.Peer-Reviewed Original ResearchConceptsMalignant lymphomaTreatment decisionsPresentation of lymphomaPrimary extranodal lymphomaMajority of patientsUntreated malignant lymphomaPattern of involvementMajority of casesLymphatic irradiationProspective stagingSurgical stagingExtranodal lymphomaExtranodal sitesHaematogenous spreadSystemic treatmentClinical courseConsecutive patientsLymph nodesDisease extentHodgkin's diseaseDisseminated involvementAppropriate treatmentLymphatic extensionPrimary manifestationHigh dose
1968
Heart in malignant lymphoma (Hodgkin's disease, lymphosarcoma, reticulum cell sarcoma and mycosis fungoides) A study of 196 autopsy cases∗
Roberts W, Glancy D, Devita V. Heart in malignant lymphoma (Hodgkin's disease, lymphosarcoma, reticulum cell sarcoma and mycosis fungoides) A study of 196 autopsy cases∗. The American Journal Of Cardiology 1968, 22: 85-107. PMID: 4873149, DOI: 10.1016/0002-9149(68)90250-6.Peer-Reviewed Original ResearchConceptsCardiac lymphomaMalignant lymphomaHodgkin's diseaseMycosis fungoidesIncidence of dyspneaCent of patientsReticulum cell sarcomaUnderlying cardiac conditionCardiac metastasisElectrocardiographic disturbancesVentricular gallopChest painPulmonary lymphomaPrecordial murmurCardiac dysfunctionLymphomatous involvementClinical findingsCell sarcomaCardiac conditionsGross examinationLymphomaPatientsCardiac chambersFocal nodulesHistologic sections