2023
Multicenter Study of a Risk Prediction Model for Critically Ill Children at High-Risk for Hospital-Acquired Venous Thromboembolism: Findings from the Children's Hospital-Acquired Thrombosis (CHAT) Consortium
Jaffray J, Mosha M, Branchford B, Amankwah E, Faustino E, Krava E, Stillings A, Young G, Goldenberg N. Multicenter Study of a Risk Prediction Model for Critically Ill Children at High-Risk for Hospital-Acquired Venous Thromboembolism: Findings from the Children's Hospital-Acquired Thrombosis (CHAT) Consortium. Blood 2023, 142: 809. DOI: 10.1182/blood-2023-187395.Peer-Reviewed Original ResearchHospital-acquired venous thromboembolismPediatric intensive care unitCongenital heart diseaseIll childrenMultivariable logistic regression modelAdmission/transferAutoimmune/inflammatory disordersCentral venous cathetersLength of hospitalizationCentral venous catheterizationDays post dischargeIntensive care unitUnivariate logistic regressionSubset of childrenP-valueLogistic regression modelsRisk assessment modelPICU admissionThromboprophylaxis measuresVenous thromboembolismChart reviewProspective cohortVenous cathetersCardiac surgeryMedian ageHospital-Acquired Venous Thromboembolism and Invasive Mechanical Ventilation: A Report From the Children’s Hospital Acquired Thrombosis Consortium
Sochet A, Jaffray J, Branchford B, Havlicek E, Mosha M, Amankwah E, Ignjatovic V, Faustino E, Goldenberg N. Hospital-Acquired Venous Thromboembolism and Invasive Mechanical Ventilation: A Report From the Children’s Hospital Acquired Thrombosis Consortium. Pediatric Critical Care Medicine 2023, 25: e82-e90. PMID: 37882641, PMCID: PMC10843146, DOI: 10.1097/pcc.0000000000003383.Peer-Reviewed Original ResearchHospital-acquired venous thromboembolismInvasive mechanical ventilationIMV durationVenous thromboembolismMechanical ventilationIll childrenDeep venous thrombosesPatient age groupsCase-control studyMultivariate logistic modelThromboprophylaxis practiceVenous thrombosesPrimary outcomeRisk stratificationThromboprophylaxis trialCatheterization dataMobility scoreAge groupsSecondary analysisDays durationThromboembolismLonger lengthAssociative statisticsChildrenDurationHospital-acquired venous thromboembolism during invasive mechanical ventilation in children: a single-center, retrospective cohort study
Havlicek E, Goldman Z, Faustino E, Ignjatovic V, Goldenberg N, Sochet A. Hospital-acquired venous thromboembolism during invasive mechanical ventilation in children: a single-center, retrospective cohort study. Journal Of Thrombosis And Haemostasis 2023, 21: 3145-3152. PMID: 37423387, DOI: 10.1016/j.jtha.2023.06.035.Peer-Reviewed Original ResearchConceptsHospital-acquired venous thromboembolismInvasive mechanical ventilationRetrospective cohort studyVenous thromboembolismMechanical ventilationEndotracheal intubationCohort studyIll childrenRisk factorsGeneral pediatric intensive care unit populationPediatric intensive care unit populationConcurrent central venous cathetersIntensive care unit populationExtremity deep venous thrombosisPediatric intensive care unitHypercoagulability risk factorsDeep venous thrombosisCentral venous cathetersIntensive care unitEligible encountersIMV durationPulmonary embolismSecondary outcomesVenous cathetersPrimary outcome
2022
Mechanical Ventilation and Hospital-Acquired Venous Thromboembolism Among Critically Ill Children.
Sochet A, Havlicek E, Faustino E, Goldenberg N. Mechanical Ventilation and Hospital-Acquired Venous Thromboembolism Among Critically Ill Children. Hospital Pediatrics 2022, 12: 1099-1109. PMID: 36349533, DOI: 10.1542/hpeds.2022-006697.Peer-Reviewed Original ResearchConceptsHospital-acquired venous thromboembolismDeep venous thrombosisMechanical ventilationMultivariable logistic regressionIll childrenVenous thromboembolismCohort studyVenous thrombosisRegistry-based cohort studyExtremity deep venous thrombosisLogistic regressionHA-VTE eventsInvasive mechanical ventilationRetrospective cohort studyVTE risk factorsCentral venous catheterizationYears of ageHospital dischargePulmonary embolismPrimary outcomeVenous catheterizationRisk factorsClinical trialsProspective validationSystem registry
2021
Performance of an Electronic Decision Support System as a Therapeutic Intervention During a Multicenter PICU Clinical Trial Heart and Lung Failure-Pediatric Insulin Titration Trial (HALF-PINT)
Hirshberg E, Alexander J, Asaro L, Coughlin-Wells K, Steil G, Spear D, Stone C, Nadkarni V, Agus M, Investigators H, Agus M, Wypij D, Asaro L, Nadkarni V, Srinivasan V, Biagas K, Mourani P, Chima R, Thomas N, Li S, Pinto A, Newth C, Hassinger A, Bysani K, Rehder K, Faustino E, Kandil S, Hirshberg E, Wintergerst K, Schwarz A, Bagdure D, Marsillio L, Cvijanovich N, Pham N, Quasney M, Flori H, Federman M, Nett S, Pinto N, Viteri S, Schneider J, Medar S, Sapru A, McQuillen P, Babbitt C, Lin J, Jouvet P, Yanay O, Allen C, Luckett P, Fackler J, Rozen T. Performance of an Electronic Decision Support System as a Therapeutic Intervention During a Multicenter PICU Clinical Trial Heart and Lung Failure-Pediatric Insulin Titration Trial (HALF-PINT). CHEST Journal 2021, 160: 919-928. PMID: 33932465, PMCID: PMC8449010, DOI: 10.1016/j.chest.2021.04.049.Peer-Reviewed Original ResearchConceptsLung Failure-Pediatric INsulin Titration trialBlood glucose targetsCritical care trialsManagement of hyperglycemiaTitration trialCare trialsGlucose targetsCDS toolElectronic clinical decision support systemLow complianceBlood glucose metricsIll pediatric patientsObservational retrospective studyElectronic decision support systemClinical decision support systemInotropic supportPediatric patientsPatient factorsRetrospective studyClinician factorsIll childrenGlucose metricsPatientsTherapeutic interventionsStudy design
2020
Long-Term Neurobehavioral and Quality of Life Outcomes of Critically Ill Children after Glycemic Control
Biagas K, Hinton V, Hasbani N, Luckett P, Wypij D, Nadkarni V, Agus M, investigators H, Srinivasan V, Mourani P, Chima R, Thomas N, Li S, Pinto A, Newth C, Hassinger A, Bysani K, Rehder K, Faustino E, Kandil S, Hirshberg E, Wintergerst K, Schwarz A, Bagdure D, Marsillio L, Cvijanovich N, Pham N, Quasney M, Flori H, Federman M, Nett S, Pinto N, Viteri S, Schneider J, Medar S, Sapru A, McQuillen P, Babbitt C, Lin J, Jouvet P, Yanay O, Allen C, Asaro L, Coughlin-Wells K, French J, Natarajan A, Network T. Long-Term Neurobehavioral and Quality of Life Outcomes of Critically Ill Children after Glycemic Control. The Journal Of Pediatrics 2020, 218: 57-63.e5. PMID: 31910992, PMCID: PMC7122648, DOI: 10.1016/j.jpeds.2019.10.055.Peer-Reviewed Original ResearchConceptsHealth-related qualityHigher-target groupGlycemic controlLife outcomesIll childrenPediatric QualityProspective longitudinal cohort studyIntensive care dischargeTarget glycemic controlTight glycemic controlLongitudinal cohort studyRisk of mortalityLack of benefitRespiratory failureCohort studyHospital dischargeInsulin titrationSecondary outcomesPrimary outcomeCare dischargeEligible childrenChild Behavior ChecklistOverall healthTotal healthVineland Adaptive Behavior Scales
2018
Sedation Management for Critically Ill Children with Pre-Existing Cognitive Impairment
Best K, Asaro L, Curley M, Investigators R, Wypij D, Allen G, Angus D, Ascenzi J, Bateman S, Borasino S, Bowens C, Bysani G, Cheifetz I, Cowl A, Dodson B, Faustino E, Fineman L, Flori H, Franck L, Gedeit R, Grant M, Harabin A, Haskins-Kiefer C, Hertzog J, Hutchins L, Kirby A, Lebet R, Matthay M, McLaughlin G, Natale J, Oren P, Polavarapu N, Schneider J, Schwarz A, Shanley T, Simone S, Singer L, Sorce L, Truemper E, Vander Heyden M, Watson R, Wells C. Sedation Management for Critically Ill Children with Pre-Existing Cognitive Impairment. The Journal Of Pediatrics 2018, 206: 204-211.e1. PMID: 30527750, PMCID: PMC6389364, DOI: 10.1016/j.jpeds.2018.10.042.Peer-Reviewed Original ResearchConceptsPediatric intensive care unitIntensive care unitCognitive impairmentSedation managementCare unitIll childrenStudy daysSevere pediatric acute respiratory distress syndromePediatric acute respiratory distress syndromePediatric Cerebral Performance CategoryAcute respiratory distress syndromePre-existing cognitive impairmentSedation management practicesAcute respiratory failureCerebral Performance CategoryEpisodes of painDevelopment of painRespiratory distress syndromeSedation assessment toolsIatrogenic withdrawal symptomsNeurotypical subjectsMore study daysAssessment toolSedative requirementsRespiratory failure
2017
Racial and Ethnic Disparities in Parental Refusal of Consent in a Large, Multisite Pediatric Critical Care Clinical Trial
Natale J, Lebet R, Joseph J, Ulysse C, Ascenzi J, Wypij D, Curley M, Investigators R, Curley M, Wypij D, Allen G, Angus D, Asaro L, Ascenzi J, Bateman S, Borasino S, Bowens C, Bysani G, Cheifetz I, Cowl A, Dodson B, Faustino E, Fineman L, Flori H, Franck L, Gedeit R, Grant M, Harabin A, Haskins-Kiefer C, Hertzog J, Hutchins L, Kirby A, Lebet R, Matthay M, McLaughlin G, Natale J, Oren P, Polavarapu N, Schneider J, Schwarz A, Shanley T, Simone S, Singer L, Sorce L, Truemper E, Vander Heyden M, Watson R, Wells C. Racial and Ethnic Disparities in Parental Refusal of Consent in a Large, Multisite Pediatric Critical Care Clinical Trial. The Journal Of Pediatrics 2017, 184: 204-208.e1. PMID: 28410087, DOI: 10.1016/j.jpeds.2017.02.006.Peer-Reviewed Original ResearchConceptsCritical care clinical trialsCare clinical trialsRespiratory failureClinical trialsParental refusalHispanic childrenAcute respiratory failureMultivariable logistic regressionWhite childrenNon-Hispanic blacksNon-Hispanic whitesRace/ethnicitySedation TitrationSedation managementIntervention armMechanical ventilationParents of childrenEnrollment criteriaPatient raceControl armIll childrenStudy consentEthnic disparitiesSecondary analysisRandomized EvaluationTight Glycemic Control in Critically Ill Children
Agus M, Wypij D, Hirshberg E, Srinivasan V, Faustino E, Luckett P, Alexander J, Asaro L, Curley M, Steil G, Nadkarni V. Tight Glycemic Control in Critically Ill Children. New England Journal Of Medicine 2017, 376: 729-741. PMID: 28118549, PMCID: PMC5444653, DOI: 10.1056/nejmoa1612348.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBlood GlucoseCardiovascular Surgical ProceduresChildChild, PreschoolCritical IllnessFemaleGlucoseHospital MortalityHumansHyperglycemiaHypoglycemic AgentsInfantInfant, NewbornInsulinIntensive Care Units, PediatricIntention to Treat AnalysisLength of StayMalePostoperative PeriodConceptsHigher-target groupLower-target groupTight glycemic controlBlood glucose levelsGlycemic controlIll childrenGlucose levelsCardiac surgeryHealth care-associated infectionsICU-free daysVentilator-free daysCritically Ill ChildrenNormal blood glucose levelsIntensive care unitCare-associated infectionsSafety monitoring boardAverage glucose levelsHigh rateContinuous glucose monitoringIll adultsOrgan dysfunctionPrimary outcomeSevere hypoglycemiaTreat analysisCare unit
2015
Thromboprophylaxis in critically ill children in Spain and Portugal
Núñez A, Fonte M, Faustino E, del estudio multicéntrico internacional PROTRACT E. Thromboprophylaxis in critically ill children in Spain and Portugal. Anales De Pediatría (English Edition) 2015, 82: 144-151. DOI: 10.1016/j.anpede.2014.05.002.Peer-Reviewed Original ResearchDeep venous thrombosisLow molecular weight heparinMolecular weight heparinIll childrenInternational PICUsWeight heparinRisk factorsEffectiveness of thromboprophylaxisUse of thromboprophylaxisPercentage of patientsFemoral vein catheterPharmacological thromboprophylaxisThromboprophylaxis useMechanical thromboprophylaxisCentral cathetersVenous thrombosisVein catheterFemoral veinResultsA totalThromboprophylaxisMethodsSecondary analysisPrior historyPatientsPICUsCranial trauma
2014
Assessing the benefits and risks of tight glycemic control in critically ill children
Faustino E, Kandil S. Assessing the benefits and risks of tight glycemic control in critically ill children. Pediatric Health Medicine And Therapeutics 2014, Volume 5: 93-98. DOI: 10.2147/phmt.s50410.Peer-Reviewed Original ResearchTight glycemic controlIntensive care unitIll childrenGlycemic controlCare unitSurgical intensive care unitSubsequent multicenter trialSingle-center trialInsulin-induced hypoglycemiaIntravenous insulinCenter trialIll adultsIll patientsMulticenter trialTrialsHypoglycemiaChildrenHigh rateMortalityCurrent literatureInsulinRiskHyperglycemiaPatientsHyperglycemia, Dysglycemia and Glycemic Control in Pediatric Critical Care
Agus M, Faustino E, Rigby M. Hyperglycemia, Dysglycemia and Glycemic Control in Pediatric Critical Care. 2014, 93-101. DOI: 10.1007/978-1-4471-6416-6_8.Peer-Reviewed Original ResearchGlycemic controlPediatric practitionersPoor outcomeProspective studyOrgan support measuresPediatric-specific dataPediatric-specific protocolsMore definitive dataHigher illness severityPediatric critical careInternational consensus statementProspective trialGlycemic managementIll patientsPediatric ICUIllness severityHigh morbidityHypoglycemic ratePatient populationPediatric intensivistsPediatric studiesSevere illnessIll childrenConsensus statementCritical care