2024
Testing the structural disconnection hypothesis: Myelin content correlates with memory in healthy aging
Mendez Colmenares A, Thomas M, Anderson C, Arciniegas D, Calhoun V, Choi I, Kramer A, Li K, Lee J, Lee P, Burzynska A. Testing the structural disconnection hypothesis: Myelin content correlates with memory in healthy aging. Neurobiology Of Aging 2024, 141: 21-33. PMID: 38810596, PMCID: PMC11290458, DOI: 10.1016/j.neurobiolaging.2024.05.013.Peer-Reviewed Original ResearchDisconnection hypothesisVirginia Cognitive Aging ProjectHypothesis of cognitive agingFractional anisotropyAssociated with reduced memory performanceDeterioration of white matterAge-related memory lossPrefrontal white matterGenu of the corpus callosumMyelin water fractionVoxel-wise analysisWhite matterCorpus callosumExecutive functionCognitive agingDiffusion tensor imagingMemory performancePrefrontal WMStructural equation modelingWM microstructureAge differencesProcessing speedStructural disconnectionCognitive declineHealthy participants
2023
Metabolic syndrome and adiposity: Risk factors for decreased myelin in cognitively healthy adults
Burzynska A, Anderson C, Arciniegas D, Calhoun V, Choi I, Colmenares A, Hiner G, Kramer A, Li K, Lee J, Lee P, Oh S, Umland S, Thomas M. Metabolic syndrome and adiposity: Risk factors for decreased myelin in cognitively healthy adults. Cerebral Circulation - Cognition And Behavior 2023, 5: 100180. PMID: 38162292, PMCID: PMC10757180, DOI: 10.1016/j.cccb.2023.100180.Peer-Reviewed Original ResearchMetS risk scoreRisk scoreRisk factorsMetabolic syndromeCognitively healthy adultsHealthy adultsTreatment of cognitive declineNeurologically healthy adultsCluster of conditionsPathophysiology of dementiaElevated blood pressureExcess adiposityChronic diseasesContext of MetSRandomized clinical trialsMyelin water fractionWhite matterDementiaCognitive dysfunctionCognitive declineMaintenance of myelin integrityLate-myelinatingMetSAdiposity reductionAssociation fibers