The brain structure, inflammatory, and genetic mechanisms mediate the association between physical frailty and depression
Jiang R, Noble S, Rosenblatt M, Dai W, Ye J, Liu S, Qi S, Calhoun V, Sui J, Scheinost D. The brain structure, inflammatory, and genetic mechanisms mediate the association between physical frailty and depression. Nature Communications 2024, 15: 4411. PMID: 38782943, PMCID: PMC11116547, DOI: 10.1038/s41467-024-48827-8.Peer-Reviewed Original ResearchConceptsIncident depressionPre-frailPhysical frailtyFrail individualsPopulation attributable fraction analysisRisk factors of depressionMendelian randomization analysisFactors of depressionPotential causal effectModifiable risk factorsNon-frail individualsCross-sectional studyEffect of frailtyHigher disease burdenUK BiobankRandomization analysisBrain volumeDepression casesDisease burdenFrailtyRegional brain volumesIncreased riskDepressionHigh riskFollow-upOral ketamine effects on dynamics of functional network connectivity in patients treated for chronic suicidality
Shan Z, Can A, Mohamed A, Dutton M, Hermens D, Calhoun V, Williams L, Bennett M, Lagopoulos J. Oral ketamine effects on dynamics of functional network connectivity in patients treated for chronic suicidality. European Archives Of Psychiatry And Clinical Neuroscience 2024, 1-11. PMID: 38772940, DOI: 10.1007/s00406-024-01831-x.Peer-Reviewed Original ResearchBeck Scale for Suicide IdeationBeck Scale for Suicidal Ideation scoresChronic suicidalityFollow-upPersistent respondingScale for Suicide IdeationCognitive control statesBrain statesSuicide-preventive effectsResting-state functional MRIMechanisms of ketamineDynamic functional connectivity analysisFunctional network connectivityPost-treatment patientsCharacteristics of patientsTrial's primary endpointPost-treatmentKetamine trialsBrain mechanismsKetamine effectsKetamine treatmentSuicidal ideationBrain changesFunctional MRIPrimary endpoint