Metabolic syndrome and adiposity: Risk factors for decreased myelin in cognitively healthy adults
Burzynska A, Anderson C, Arciniegas D, Calhoun V, Choi I, Colmenares A, Hiner G, Kramer A, Li K, Lee J, Lee P, Oh S, Umland S, Thomas M. Metabolic syndrome and adiposity: Risk factors for decreased myelin in cognitively healthy adults. Cerebral Circulation - Cognition And Behavior 2023, 5: 100180. PMID: 38162292, PMCID: PMC10757180, DOI: 10.1016/j.cccb.2023.100180.Peer-Reviewed Original ResearchMetS risk scoreRisk scoreRisk factorsMetabolic syndromeCognitively healthy adultsHealthy adultsTreatment of cognitive declineNeurologically healthy adultsCluster of conditionsPathophysiology of dementiaElevated blood pressureExcess adiposityChronic diseasesContext of MetSRandomized clinical trialsMyelin water fractionWhite matterDementiaCognitive dysfunctionCognitive declineMaintenance of myelin integrityLate-myelinatingMetSAdiposity reductionAssociation fibersSymmetric data-driven fusion of diffusion tensor MRI: Age differences in white matter
Colmenares A, Hefner M, Calhoun V, Salerno E, Fanning J, Gothe N, McAuley E, Kramer A, Burzynska A. Symmetric data-driven fusion of diffusion tensor MRI: Age differences in white matter. Frontiers In Neurology 2023, 14: 1094313. PMID: 37139071, PMCID: PMC10149813, DOI: 10.3389/fneur.2023.1094313.Peer-Reviewed Original ResearchDiffusion tensor imagingAge differencesExamination of age differencesPattern of age differencesFractional anisotropyRadial diffusivityJoint independent component analysisCognitively healthy adultsWhite matterDiffusion tensor imaging parametersFluid abilitiesPrefrontal WMProcessing speedDiagnostic classificationWM pathologyDiffusion tensor imaging datasetsAging WMUnimodal analysisTensor imagingIndependent component analysisClinical samplesHealthy agingCognitionCorpus callosumHealthy adults