2024
Cross-continental environmental and genome-wide association study on children and adolescent anxiety and depression
Thapaliya B, Ray B, Farahdel B, Suresh P, Sapkota R, Holla B, Mahadevan J, Chen J, Vaidya N, Perrone-Bizzozero N, Benegal V, Schumann G, Calhoun V, Liu J. Cross-continental environmental and genome-wide association study on children and adolescent anxiety and depression. Frontiers In Psychiatry 2024, 15: 1384298. PMID: 38827440, PMCID: PMC11141390, DOI: 10.3389/fpsyt.2024.1384298.Peer-Reviewed Original ResearchEarly life stressAdolescent anxietyLife stressMega-analysisCognitive Development StudyHypothalamic-pituitary-adrenal axisSupport IndexAssociated with anxietyRisk of anxietyExternalizing disordersAdolescent brainGenome-wide association studiesGenetic vulnerabilityAnxietyGenome-wide association analysisPublic health concernDepressionMental healthLinear mixed-effects modelsEnvironmental factorsMixed-effects modelsAssociation studiesTissue enrichment analysisGenetic associationGenomic significance
2023
A Brainwide Risk Score for Psychiatric Disorder Evaluated in a Large Adolescent Population Reveals Increased Divergence Among Higher-Risk Groups Relative to Control Participants
Yan W, Pearlson G, Fu Z, Li X, Iraji A, Chen J, Sui J, Volkow N, Calhoun V. A Brainwide Risk Score for Psychiatric Disorder Evaluated in a Large Adolescent Population Reveals Increased Divergence Among Higher-Risk Groups Relative to Control Participants. Biological Psychiatry 2023, 95: 699-708. PMID: 37769983, PMCID: PMC10942727, DOI: 10.1016/j.biopsych.2023.09.017.Peer-Reviewed Original ResearchFunctional network connectivityHealthy control individualsPsychiatric disordersRisk scoreEarly psychosisPsychiatric riskControl individualsStudy participantsHigh-risk groupMajor depressive disorderHigh-risk patternsPsychiatric risk assessmentCognitive Development StudyUnaffected adolescentsAdolescent Brain Cognitive Development (ABCD) studyLarge adolescent populationDepressive disorderHigh riskPsychosis scoresBipolar disorderPotential biomarkersEarly screeningPsychiatric vulnerabilityAdolescent populationDisorders