Cyclic‐AMP Regulates Glycogen Synthase Kinase‐3β by a Feed‐Forward Mechanism in Polycystic Kidney Disease
Kakade V, Tao S, Zhou X, Li X, Pandey P, Rajagopal M, Rao R. Cyclic‐AMP Regulates Glycogen Synthase Kinase‐3β by a Feed‐Forward Mechanism in Polycystic Kidney Disease. The FASEB Journal 2016, 30 DOI: 10.1096/fasebj.30.1_supplement.968.28.Peer-Reviewed Original ResearchCRE-binding proteinGlycogen synthase kinase-3βCAMP response elementSynthase kinase-3βSerine/threonine protein kinaseGSK3β expressionKinase-3βCAMP-responsive genesThreonine protein kinasePolycystic kidney diseaseCyst expansionCAMP levelsPotential binding sitesFeed-forward loopInhibition of GSK3βResponsive genesTranscription factorsProtein kinaseFeed-forward mechanismResponse elementGSK3β proteinCell survivalCREB activityGSK3βActive GSK3β