2023
Adjuvant chemotherapy does not improve outcome in children with ovarian immature teratoma: A comparative analysis of clinical trial data from the Malignant Germ Cell International Consortium
Vieira A, Puthenpura V, Krailo M, Fallahazad N, Brougham M, Murray M, Frazier A, Lopes L, Pashankar F. Adjuvant chemotherapy does not improve outcome in children with ovarian immature teratoma: A comparative analysis of clinical trial data from the Malignant Germ Cell International Consortium. Pediatric Blood & Cancer 2023, 70: e30426. PMID: 37243320, DOI: 10.1002/pbc.30426.Peer-Reviewed Original ResearchConceptsOvarian immature teratomaOverall survivalImmature teratomaPostoperative chemotherapyBrazilian patientsStage IIAdjuvant chemotherapyUK cohortGrade 1 diseaseGrade 3 patientsReceipt of chemotherapyMainstay of therapyValue of chemotherapyPrimary outcome measureClinical trial dataIT patientsEntire cohortUK patientsRelapse riskBrazilian cohortOutcome measuresPractice variationChemotherapyPatientsStage I
2016
Spinal cord glioblastoma: 25years of experience from a single institution
Yanamadala V, Koffie R, Shankar G, Kumar J, Buchlak Q, Puthenpura V, Frosch M, Gudewicz T, Borges L, Shin J. Spinal cord glioblastoma: 25years of experience from a single institution. Journal Of Clinical Neuroscience 2016, 27: 138-141. PMID: 26755453, DOI: 10.1016/j.jocn.2015.11.011.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedChemoradiotherapyCombined Modality TherapyDNA MethylationFemaleGlioblastomaHumansKarnofsky Performance StatusMaleMiddle AgedNeoplasm ProteinsNeoplasm Recurrence, LocalProto-Oncogene Proteins B-rafRecovery of FunctionSpinal Cord NeoplasmsSurvival AnalysisTreatment OutcomeTumor Suppressor Protein p53ConceptsHigh-grade spinal cord gliomasSpinal cord gliomasKarnofsky performance statusFunctional statusAmerican Spine Injury Association (ASIA) scorePost-operative functional statusPost-operative radiationSubtotal surgical resectionSubset of patientsTumor recurrence rateYear survival rateTargeted molecular therapiesHigh-grade gliomasAdjuvant chemotherapyPerformance statusSurgical resectionPrimary outcomeRecurrence rateSingle institutionExcellent survivalSpinal cordPatientsAssociation scoreGrade gliomasSurvival rate