2020
trans-Resveratrol ameliorates anxiety-like behaviors and neuropathic pain in mouse model of post-traumatic stress disorder
Yuan Y, Zhen L, Li Z, Xu W, Leng H, Xu W, Zheng V, Luria V, Pan J, Tao Y, Zhang H, Cao S, Xu Y. trans-Resveratrol ameliorates anxiety-like behaviors and neuropathic pain in mouse model of post-traumatic stress disorder. Journal Of Psychopharmacology 2020, 34: 726-736. PMID: 32308103, DOI: 10.1177/0269881120914221.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factor (BDNF) expressionPhosphorylated cAMP response elementAnxiety-like behaviorNeurotrophic factor expressionNeuropathic painCAMP response elementBrain-derived neurotrophic factor levelsGlucocorticoid receptorFactor expressionProlonged stressStress-induced anxiety-like behaviorStress disorderCold allodynia testsNeurotrophic factor levelsAdrenal axis functionPain-related regionsLocomotor activity testSerum corticosterone levelsMarble burying testNumber of marblesProtein kinase APost-traumatic stress disorderEnzyme-linked immunosorbentClassical animal modelsResponse element
2010
APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex
Shimomura Y, Agalliu D, Vonica A, Luria V, Wajid M, Baumer A, Belli S, Petukhova L, Schinzel A, Brivanlou A, Barres B, Christiano A. APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex. Nature 2010, 464: 1043-1047. PMID: 20393562, PMCID: PMC3046868, DOI: 10.1038/nature08875.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBeta CateninCell DifferentiationCell LineCell ProliferationChick EmbryoChromosome MappingChromosomes, Human, Pair 18Genes, DominantGenes, ReporterHairHair FollicleHumansHypotrichosisIntracellular Signaling Peptides and ProteinsMembrane GlycoproteinsMembrane ProteinsMiceMutant ProteinsNeuronsPoint MutationScalpSignal TransductionSkinSpinal CordStem CellsWnt ProteinsXenopus laevisXenopus ProteinsConceptsHereditary hypotrichosis simplexSignal transduction pathwaysHypotrichosis simplexMesenchymal cell compartmentGenetic linkage analysisNovel Wnt inhibitorsMembrane-bound glycoproteinTransduction pathwaysHuman hair folliclesLinkage analysisAPCDD1Functional studiesHair folliclesWnt inhibitorsCell compartmentDowny hairsGenesImportant componentThick hairPathwayHairGlycoproteinCompartmentsDegenerative processFamily
2008
Specification of Motor Axon Trajectory by Ephrin-B:EphB Signaling: Symmetrical Control of Axonal Patterning in the Developing Limb
Luria V, Krawchuk D, Jessell T, Laufer E, Kania A. Specification of Motor Axon Trajectory by Ephrin-B:EphB Signaling: Symmetrical Control of Axonal Patterning in the Developing Limb. Neuron 2008, 60: 1039-1053. PMID: 19109910, DOI: 10.1016/j.neuron.2008.11.011.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsBody PatterningChick EmbryoElectroporationEmbryo, MammalianEphrinsExtremitiesGene Expression Regulation, DevelopmentalGreen Fluorescent ProteinsHomeodomain ProteinsHorseradish PeroxidaseLIM-Homeodomain ProteinsMiceMice, KnockoutModels, BiologicalMotor NeuronsMutationNeurofilament ProteinsReceptors, Eph FamilyRNA, MessengerSignal TransductionSpinal CordTranscription Factors
2007
Lateral motor column axons execute a ternary trajectory choice between limb and body tissues
Luria V, Laufer E. Lateral motor column axons execute a ternary trajectory choice between limb and body tissues. Neural Development 2007, 2: 13. PMID: 17605791, PMCID: PMC1949814, DOI: 10.1186/1749-8104-2-13.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsBody PatterningBone Morphogenetic Protein Receptors, Type ICell DifferentiationEphrinsExtremitiesGene Expression Regulation, DevelopmentalGrowth ConesHomeodomain ProteinsKruppel-Like Transcription FactorsLIM-Homeodomain ProteinsMesodermMiceMice, KnockoutMotor NeuronsMuscle, SkeletalNeuronal PlasticityPromyelocytic Leukemia Zinc Finger ProteinReceptors, Eph FamilySpinal CordTranscription FactorsConceptsLateral motor columnLMC axonsHindlimb levelsSpinal cord lateral motor columnMotor columnAxons of neuronsIntermediate choice pointsVentral flankBody tissuesMotor nervesLMC neuronsAxonal trajectoriesLimb trajectoriesAxonsTopographic map formationTarget tissuesLimbTissueTranscription factor codeVentral limbNeuronsMap formationMesenchymeInnervationNerve
2001
Expression patterns of Slit and Robo family members during vertebrate limb development
Vargesson N, Luria V, Messina I, Erskine L, Laufer E. Expression patterns of Slit and Robo family members during vertebrate limb development. Cells And Development 2001, 106: 175-180. PMID: 11472852, DOI: 10.1016/s0925-4773(01)00430-0.Peer-Reviewed Original Research
1998
Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally
Varfolomeev E, Schuchmann M, Luria V, Chiannilkulchai N, Beckmann J, Mett I, Rebrikov D, Brodianski V, Kemper O, Kollet O, Lapidot T, Soffer D, Sobe T, Avraham K, Goncharov T, Holtmann H, Lonai P, Wallach D. Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally. Immunity 1998, 9: 267-276. PMID: 9729047, DOI: 10.1016/s1074-7613(00)80609-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCaspase 8Caspase 9CaspasesCell DeathCells, CulturedCysteine EndopeptidasesDNA, ComplementaryFas ReceptorFetal DeathFibroblastsGene TargetingGenes, LethalGestational AgeMiceMice, Inbred C57BLMice, KnockoutPhenotypeReceptors, Tumor Necrosis FactorReceptors, Tumor Necrosis Factor, Member 25Transcription, GeneticConceptsFas/APO1Death inductionJun N-terminal kinaseHeart muscle developmentCaspase-8 geneCell death inductionWild-type fibroblastsN-terminal kinaseTNF receptorNull embryosMuscle developmentAlpha phosphorylationHematopoietic colony-forming cellsCaspase-8Cell deathColony-forming cellsIkappaB-alpha phosphorylationTargeted disruptionNonredundant roleEmbryonal developmentEmbryosAPO1Fibroblast strainsNGF familyReceptorsMaternally expressed PGK-Cre transgene as a tool for early and uniform activation of the Cre site-specific recombinase
Lallemand Y, Luria V, Haffner-Krausz R, Lonai P. Maternally expressed PGK-Cre transgene as a tool for early and uniform activation of the Cre site-specific recombinase. Transgenic Research 1998, 7: 105-112. PMID: 9608738, DOI: 10.1023/a:1008868325009.Peer-Reviewed Original Research