2016
Possible Interaction of Anti–PD-1 Therapy with the Effects of Radiosurgery on Brain Metastases
Alomari AK, Cohen J, Vortmeyer AO, Chiang A, Gettinger S, Goldberg S, Kluger HM, Chiang VL. Possible Interaction of Anti–PD-1 Therapy with the Effects of Radiosurgery on Brain Metastases. Cancer Immunology Research 2016, 4: 481-487. PMID: 26994250, DOI: 10.1158/2326-6066.cir-15-0238.Peer-Reviewed Original ResearchConceptsStereotactic radiosurgeryBrain metastasesInitiation of immunotherapyPD-1 mAbImmune-modulating therapyModalities of treatmentRadiologic progressionSurgical resectionSystemic therapyDeath-1Radiologic findingsMetastatic malignancyReactive astrocytosisPathologic examinationTreatment regimensHistopathologic examinationWall infiltrationT lymphocytesPatientsTumor progressionMonoclonal antibodiesBiologic interactionsRadiation-induced changesImmunotherapyMalignancy
2014
Radiologic and histologic consequences of radiosurgery for brain tumors
Alomari A, Rauch PJ, Orsaria M, Minja FJ, Chiang VL, Vortmeyer AO. Radiologic and histologic consequences of radiosurgery for brain tumors. Journal Of Neuro-Oncology 2014, 117: 33-42. PMID: 24442402, DOI: 10.1007/s11060-014-1359-8.Peer-Reviewed Original ResearchConceptsGamma knife radiosurgeryNon-enhancing regionsNon-enhancing areasRecurrent tumorsEncephalopathic changesBrain lesionsRecurrent tumor growthMalignant brain lesionsGadolinium-enhanced MRIHigh clinical relevanceDemyelinating changesSeparate biopsiesNon-enhancing componentsInflammatory demyelinationRadiological changesHistologic consequencesImaging changesReactive astrocytosisHistopathological changesKnife radiosurgeryPathological changesCoagulative necrosisBrain tumorsClinical relevanceHistological results