2022
Synchronous glioblastoma and brain metastases: illustrative case
Shahsavari N, Ahmad M, Sekar V, Meola A, Hancock SL, Chang SD, Chiang VL. Synchronous glioblastoma and brain metastases: illustrative case. Journal Of Neurosurgery Case Lessons 2022, 3: case21714. PMID: 36273867, PMCID: PMC9379681, DOI: 10.3171/case21714.Peer-Reviewed Original ResearchBrain metastasesMultiple brain metastasesRadiosurgical treatmentSignificant perilesional edemaSimilar radiological featuresMetastatic lung adenocarcinomaRight temporal lobeStereotactic radiosurgical treatmentMaintenance nivolumabRadiological featuresMidline shiftPerilesional edemaTreatment courseTissue confirmationLung adenocarcinomaStereotactic radiosurgeryTemporal lobeMetastasisIllustrative caseIncorrect diagnosisRadiological surveillanceSynchronous presenceIDH-wildtypeGlioblastomaLesions
2019
Perilesional edema in brain metastases: potential causes and implications for treatment with immune therapy
Tran TT, Mahajan A, Chiang VL, Goldberg SB, Nguyen DX, Jilaveanu LB, Kluger HM. Perilesional edema in brain metastases: potential causes and implications for treatment with immune therapy. Journal For ImmunoTherapy Of Cancer 2019, 7: 200. PMID: 31362777, PMCID: PMC6668163, DOI: 10.1186/s40425-019-0684-z.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, IntravenousAntibodies, Monoclonal, HumanizedAntigens, CD34Antineoplastic Agents, ImmunologicalBlood-Brain BarrierBrain EdemaBrain NeoplasmsCarcinoma, Non-Small-Cell LungClinical Trials, Phase II as TopicDrug Administration ScheduleHumansLung NeoplasmsMelanomaRetrospective StudiesTight JunctionsTreatment OutcomeTumor Cells, CulturedConceptsMelanoma brain metastasesBrain metastasesPerilesional edemaVessel densityEdema volumeSensitive tumorsBlood-brain barrier model systemNon-small cell lungTight junction resistancePhase II clinical trialSignificant perilesional edemaUntreated brain metastasesBlood-brain barrierPre-clinical modelsDegree of edemaTumor mass effectPotential causesMelanoma brainShort-term cultureExtracranial metastasesImmune therapyMelanoma patientsSignificant morbidityCell lungLarge tumors