2024
Patterns of brain metastases response to immunotherapy with pembrolizumab
Mahajan A, Goldberg S, Weiss S, Tran T, Singh K, Joshi K, Aboian M, Kluger H, Chiang V. Patterns of brain metastases response to immunotherapy with pembrolizumab. Journal Of Neuro-Oncology 2024, 1-7. PMID: 38963658, DOI: 10.1007/s11060-024-04754-8.Peer-Reviewed Original ResearchNon-small cell lung cancerBrain metastasesComplete resolutionLung cancerMedian time to CNS progressionLesion progressionNon-small cell lung cancer patientsModified RECIST criteriaPD-1 inhibitorsTrial of pembrolizumabEffective systemic treatmentResponse to immunotherapyPhase II trialCell lung cancerMethodsThis retrospective studyLocal treatment decisionsPurposeCentral nervous systemCNS progressionRECIST criteriaPD-1Local therapySystemic treatmentMRI evaluationResponse assessmentRetrospective study
2022
Combination laser interstitial thermal therapy plus stereotactic radiotherapy increases time to progression for biopsy-proven recurrent brain metastases
Grabowski MM, Srinivasan ES, Vaios EJ, Sankey EW, Otvos B, Krivosheya D, Scott A, Olufawo M, Ma J, Fomchenko EI, Herndon JE, Kim AH, Chiang VL, Chen CC, Leuthardt EC, Barnett GH, Kirkpatrick JP, Mohammadi AM, Fecci PE. Combination laser interstitial thermal therapy plus stereotactic radiotherapy increases time to progression for biopsy-proven recurrent brain metastases. Neuro-Oncology Advances 2022, 4: vdac086. PMID: 35795470, PMCID: PMC9248774, DOI: 10.1093/noajnl/vdac086.Peer-Reviewed Original ResearchLaser interstitial thermal therapyRecurrent brain metastasesBrain metastasis recurrenceKarnofsky performance statusBrain metastasesStereotactic radiotherapyLesion progressionInterstitial thermal therapyMetastasis recurrenceEfficacy of LITTNeuro-Oncology Brain Metastases criteriaSRT failurePercent of patientsAcademic medical centerContrast-enhancing volumeMetastasis (TNM) criteriaOpen resectionPerformance statusProspective trialMedian timeRetrospective studyTumor recurrenceInclusion criteriaMedical CenterEffective treatment
2021
Role of Gamma Knife Radiosurgery in Small Cell Lung Cancer: A Multi-Institutional Retrospective Study of the International Radiosurgery Research Foundation (IRRF)
Cifarelli C, Vargo J, Fang W, Liscak R, Guseynova K, Warnick R, Lee C, Yang H, Borghei-Razavi H, Maiti T, Siddiqui Z, Yuan J, Grills I, Mathieu D, Touchette C, Cordeiro D, Chiang V, Hess J, Tien C, Faramand A, Kano H, Barnett G, Sheehan J, Lunsford L. Role of Gamma Knife Radiosurgery in Small Cell Lung Cancer: A Multi-Institutional Retrospective Study of the International Radiosurgery Research Foundation (IRRF). Neurosurgery 2021, 89: s20-s20. DOI: 10.1093/neuros/nyz428_s020.Peer-Reviewed Original Research
2018
SURG-20. LASER-INTERSTITIAL THERMAL THERAPY VERSUS CRANIOTOMY FOR TREATMENT OF RADIATION NECROSIS OR RECURRENT TUMOR IN BRAIN METASTASES FAILING RADIOSURGERY
Hong C, Deng J, Vera A, Chiang V. SURG-20. LASER-INTERSTITIAL THERMAL THERAPY VERSUS CRANIOTOMY FOR TREATMENT OF RADIATION NECROSIS OR RECURRENT TUMOR IN BRAIN METASTASES FAILING RADIOSURGERY. Neuro-Oncology 2018, 20: vi254-vi255. PMCID: PMC6216306, DOI: 10.1093/neuonc/noy148.1056.Peer-Reviewed Original ResearchLaser interstitial thermal therapyProgression-free survivalRe-growing tumorRadiation necrosisBrain metastasesMelanoma patientsSingle-surgeon retrospective studyImproved progression-free survivalLocal progression-free survivalPre-operative symptomsLog-rank testSteroid dosingSteroid taperNeurological outcomeOverall survivalRecurrent tumorsUnderwent craniotomyRetrospective studySingle institutionSubgroup analysisSurgery dateSurvival advantageCraniotomyPatientsLocal controlBreast cancer patients with brain metastasis undergoing GKRS
Abu-Khalaf M, Muralikrishnan S, Hatzis C, Canchi D, Yu JB, Chiang V. Breast cancer patients with brain metastasis undergoing GKRS. Breast Cancer 2018, 26: 147-153. PMID: 30182250, DOI: 10.1007/s12282-018-0903-3.Peer-Reviewed Original ResearchConceptsWhole-brain radiation therapyGamma knife radiosurgeryKarnofsky performance statusBrain metastasesOverall survivalBackgroundBreast cancerSurgical resectionTime of GKRSFirst gamma knife radiosurgeryFirst GKRS treatmentBrain radiation therapyBreast cancer patientsComprehensive cancer centerGKRS treatmentNeurocognitive preservationResultsMedian agePerformance statusMethodsThe recordsNeurological deathSuch patientsMultivariable analysisRetrospective studySurvival outcomesSystemic diseaseCancer Center
2017
Laser Thermal Ablation for Metastases Failing Radiosurgery: A Multicentered Retrospective Study
Chaunzwa TL, Deng D, Leuthardt EC, Tatter SB, Mohammadi AM, Barnett GH, Chiang VL. Laser Thermal Ablation for Metastases Failing Radiosurgery: A Multicentered Retrospective Study. Neurosurgery 2017, 82: 56-63. PMID: 28419284, DOI: 10.1093/neuros/nyx142.Peer-Reviewed Original ResearchConceptsRadiosurgical failureRadiation necrosisTumor regrowthAblation therapyFluid-attenuated inversion recovery signalTreatment factorsMulticentered retrospective studyKarnofsky performance statusMetastatic brain lesionsThermal ablation therapyLow complication rateTraditional treatment optionsTreatment of metastasesInversion recovery signalLaser thermal ablationBrain metastasesPreoperative symptomsComplication ratePerformance statusSymptomatic improvementSymptomatic reliefPerilesional edemaRetrospective studySurgical dataTreatment options