2023
Peritumoral edema measurements provide additional information to RANO-BM based assessment of lung cancer brain metastases after Gamma Knife therapy (P10-13.002)
Kaur M, Cassinelli G, von Reppert M, Jekel L, Varghese S, Dixe I, Omuro A, Chiang V, Aboian M. Peritumoral edema measurements provide additional information to RANO-BM based assessment of lung cancer brain metastases after Gamma Knife therapy (P10-13.002). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000203091.Peer-Reviewed Original ResearchUse of stereotactic radiosurgery in treatment of brain metastases from pediatric extracranial solid tumors
Xu S, Campbell A, Chiang V, Bindra R, Vasquez J, Pashankar F. Use of stereotactic radiosurgery in treatment of brain metastases from pediatric extracranial solid tumors. Pediatric Blood & Cancer 2023, 70: e30303. PMID: 36975152, DOI: 10.1002/pbc.30303.Peer-Reviewed Original Research
2022
NIMG-02. PACS-INTEGRATED AUTO-SEGMENTATION WORKFLOW FOR BRAIN METASTASES USING NNU-NET
Jekel L, Bousabarah K, Lin M, Merkaj S, Kaur M, Avesta A, Aneja S, Omuro A, Chiang V, Scheffler B, Aboian M. NIMG-02. PACS-INTEGRATED AUTO-SEGMENTATION WORKFLOW FOR BRAIN METASTASES USING NNU-NET. Neuro-Oncology 2022, 24: vii162-vii162. PMCID: PMC9661012, DOI: 10.1093/neuonc/noac209.622.Peer-Reviewed Original ResearchNIMG-04. LONGITUDINAL TRACKING OF PERITUMORAL EDEMA VOLUME USING PACS-INTEGRATED TOOLS PROVIDES CRITICAL INFORMATION IN TREATMENT ASSESSMENT OF NSCLC BRAIN METASTASES AFTER RADIOSURGERY
Kaur M, Petersen G, von Reppert M, Jekel L, de Santo I, Varghese S, Chiang V, Aboian M. NIMG-04. LONGITUDINAL TRACKING OF PERITUMORAL EDEMA VOLUME USING PACS-INTEGRATED TOOLS PROVIDES CRITICAL INFORMATION IN TREATMENT ASSESSMENT OF NSCLC BRAIN METASTASES AFTER RADIOSURGERY. Neuro-Oncology 2022, 24: vii162-vii162. PMCID: PMC9661156, DOI: 10.1093/neuonc/noac209.624.Peer-Reviewed Original ResearchNSCLC brain metastasesPeritumoral edema volumeBrain metastasesEdema volumeLongest diameterGamma KnifeClinical practiceCE lesionsCommon intracranial malignancyStandard of careFLAIR hyperintense regionVolumetric measurementsIntracranial malignanciesEdema/Lung cancerTreatment responsePeritumoral volumesClinical informationPeritumoral edemaLongitudinal assessmentTreatment assessmentNeuroradiology practiceHyperintense regionsMetastasisLesions
2021
Recognition and Management of Adverse Radiation Effects
Cheok S, Hansen J, Chiang V. Recognition and Management of Adverse Radiation Effects. 2021, 391-404. DOI: 10.1201/9781003167464-36.ChaptersAdverse radiation effectsRadiation necrosisStereotactic radiosurgeryRole of SRSImmune-mediated componentLaser interstitial thermotherapyMore brain lesionsBrain metastasesSystemic therapyIntracranial pathologyMalignant pathologyBrain lesionsNecrosisInterstitial thermotherapyPathologyContemporary evidenceBevacizumabCraniotomyMetastasisTherapyLesionsRadiosurgerySteroidsManagement of Brain Metastases
Collier E, Chiang V, Goldberg S. Management of Brain Metastases. Current Cancer Research 2021, 115-137. DOI: 10.1007/978-3-030-74028-3_6.Peer-Reviewed Original ResearchBrain metastasesSystemic therapyLocal therapyAsymptomatic brain metastasesNew systemic therapiesSource of morbidityInclusion of patientsMalignant brain tumorsQuality of lifeNew cancer treatmentsSignificant morbidityWorse prognosisPatient survivalCNS diseaseLung cancerClinical trialsBrain tumorsMetastasisNSCLCTherapyCancer treatmentSmall molecule drugsFrequent originMorbidityTreatment
2020
Outcomes Of Stereotactic Radiosurgery And Immunotherapy In Renal Cell Carcinoma With Brain Metastases
Uezono H, Nam D, Yu J, Chiang V. Outcomes Of Stereotactic Radiosurgery And Immunotherapy In Renal Cell Carcinoma With Brain Metastases. International Journal Of Radiation Oncology • Biology • Physics 2020, 108: e734. DOI: 10.1016/j.ijrobp.2020.07.133.Peer-Reviewed Original ResearchReport from the American Radium Society (ARS) Appropriate Use Criteria Brain Malignancies Panel: Treatment of Multiple Brain Metastases
Milano M, Chiang V, Soltys S, Wang T, Lo S, Brackett A, Gephart M, Nagpal S, Jabbari S, Halasz L, Chao S, Garg A, Knisely J, Sahgal A, Chang E. Report from the American Radium Society (ARS) Appropriate Use Criteria Brain Malignancies Panel: Treatment of Multiple Brain Metastases. International Journal Of Radiation Oncology • Biology • Physics 2020, 108: e27-e28. DOI: 10.1016/j.ijrobp.2020.02.527.Peer-Reviewed Original Research
2019
Combining Radiosurgery and Systemic Therapies for Treatment of Brain Metastases
Chiang V, Cheok S. Combining Radiosurgery and Systemic Therapies for Treatment of Brain Metastases. 2019, 247-258. DOI: 10.1007/978-3-030-23417-1_19.Peer-Reviewed Original ResearchRADI-34. USE OF LOW-DOSE STEREOTACTIC RADIOSURGERY FOR ADVANCED BRAIN METASTASES
Yang D, Yu J, Chiang V. RADI-34. USE OF LOW-DOSE STEREOTACTIC RADIOSURGERY FOR ADVANCED BRAIN METASTASES. Neuro-Oncology Advances 2019, 1: i28-i28. PMCID: PMC7213353, DOI: 10.1093/noajnl/vdz014.126.Peer-Reviewed Original ResearchGamma Knife stereotactic radiosurgeryBrain metastasesStereotactic radiosurgeryOverall survivalDisease progressionTime to disease progressionBRAF V600E tumorsMutation-targeted therapiesMedian overall survivalMetastatic melanoma patientsTreat brain metastasesPoor performance statusTumor controlMelanoma patientsSystemic therapyAdvanced diseasePerformance statusRe-treatmentTesticular cancerComposite endpointMetastasisSystemic agentsStudy exitImmunotherapyPatientsSURG-06. LASER INTERSTITIAL THERMAL THERAPY COMPARED TO CRANIOTOMY FOR TREATMENT OF RADIATION NECROSIS OR RECURRENT TUMOR IN BRAIN METASTASES FAILING RADIOSURGERY
Hong C, Deng D, Sujijantarat N, Vera A, Chiang V. SURG-06. LASER INTERSTITIAL THERMAL THERAPY COMPARED TO CRANIOTOMY FOR TREATMENT OF RADIATION NECROSIS OR RECURRENT TUMOR IN BRAIN METASTASES FAILING RADIOSURGERY. Neuro-Oncology Advances 2019, 1: i31-i32. PMCID: PMC7213364, DOI: 10.1093/noajnl/vdz014.141.Peer-Reviewed Original ResearchLaser interstitial thermal therapyProgression-free survivalBrain metastasesRadiation necrosisOverall survivalStereotactic radiosurgeryRecurrent tumorsSingle-institution chart reviewPost-operative salvagePre-operative symptomsSub-group analysisViable alternative treatmentRe-growing tumorSteroid taperNeurological outcomeChart reviewSymptom reliefUnderwent craniotomyTumor lesionsAlternative treatmentCraniotomyLocal controlPatientsMetastasisSmall lesions
2018
Salvage Stereotactic Radiosurgery is Associated with Improved Overall Survival Compared to Whole Brain Radiation in the Setting of Progressive Brain Metastases
Soike M, McTyre E, Farris M, Ayala-Peacock D, Hepel J, Page B, Kleinberg L, Contessa J, Chiang V, Cramer C, Ruiz J, Pasche B, Tatter S, Fiveash J, Ahluwalia M, Chao S, Braunstein S, Attia A, Chan M. Salvage Stereotactic Radiosurgery is Associated with Improved Overall Survival Compared to Whole Brain Radiation in the Setting of Progressive Brain Metastases. International Journal Of Radiation Oncology • Biology • Physics 2018, 102: s144. DOI: 10.1016/j.ijrobp.2018.06.350.Peer-Reviewed Original ResearchA Pilot/Phase II Study of Stereotactic Radiosurgery for Brain Metastases Using Rational Dose Selection
Yu J, Singh C, Bindra R, Contessa J, Husain Z, Hansen J, Park H, Roberts K, Bond J, Tien C, Guo F, Colaco R, Housri N, Magnuson W, Omay B, Chiang V. A Pilot/Phase II Study of Stereotactic Radiosurgery for Brain Metastases Using Rational Dose Selection. International Journal Of Radiation Oncology • Biology • Physics 2018, 102: e372-e373. DOI: 10.1016/j.ijrobp.2018.07.1113.Peer-Reviewed Original ResearchPerilesional edema and blood vessel characteristics in brain metastases and implications for treatment with immune therapy.
Tran T, Jilaveanu L, Mahajan A, Goldberg S, Nguyen D, Chiang V, Kluger H. Perilesional edema and blood vessel characteristics in brain metastases and implications for treatment with immune therapy. Journal Of Clinical Oncology 2018, 36: 9572-9572. DOI: 10.1200/jco.2018.36.15_suppl.9572.Peer-Reviewed Original Research
2017
SURG-06. LASER ABLATION IN STEREOTACTIC NEUROSURGERY (LAISE): A MULTI-INSTITUTIONAL RETROSPECTIVE ANALYSIS OF LITT FOR BRAIN METASTASIS
Sloan A, Tatter S, Mohammadi A, Judy K, Prabhu S, Lovick D, Chamoun R, Chiang V, Leuthardt E. SURG-06. LASER ABLATION IN STEREOTACTIC NEUROSURGERY (LAISE): A MULTI-INSTITUTIONAL RETROSPECTIVE ANALYSIS OF LITT FOR BRAIN METASTASIS. Neuro-Oncology 2017, 19: vi236-vi236. PMCID: PMC5693010, DOI: 10.1093/neuonc/nox168.963.Peer-Reviewed Original ResearchBrain metastasesBrain tumorsMedian ECOG performance statusMulti-institutional retrospective analysisECOG performance statusMetastatic brain tumorsMedian survivalPerformance statusMedian ageNeurological deathInoperable tumorsRetrospective databaseTumor locationFrequent primaryRetrospective analysisInvasive proceduresAlternative treatmentPatientsDischarge statusMetastasisGliomasPrevious treatmentLaser interstitial thermotherapyTumorsTreatmentDiscrepancies Between Biological Markers of Primary Breast Cancer and Their Brain Metastases: An International Multicenter Study
Person O, Meattini I, Jain P, Bult P, Simone N, Kindts I, Steffens R, Weltens C, Navarria P, Belkacemi Y, Lopez J, Livi L, Baumert B, Vieites B, Limon D, Kurman N, Yu J, Chiang V, Poortmans P, Zagar T. Discrepancies Between Biological Markers of Primary Breast Cancer and Their Brain Metastases: An International Multicenter Study. International Journal Of Radiation Oncology • Biology • Physics 2017, 99: s170-s171. DOI: 10.1016/j.ijrobp.2017.06.431.Peer-Reviewed Original Research
2016
Deferring Radiation Therapy for Brain Metastases in Patients With EGFR-Mutant Non-Small Cell Lung Cancer: A Multi-Institutional Analysis
Magnuson W, Amini A, Patil T, Kavanagh B, Camidge D, Braunstein S, Boreta L, Attia A, Rana N, Contessa J, Gettinger S, Lester-Coll N, Yu J, Chiang V. Deferring Radiation Therapy for Brain Metastases in Patients With EGFR-Mutant Non-Small Cell Lung Cancer: A Multi-Institutional Analysis. International Journal Of Radiation Oncology • Biology • Physics 2016, 96: s57-s58. DOI: 10.1016/j.ijrobp.2016.06.149.Peer-Reviewed Original ResearchThe Effect of Gene Mutations on Survival in Patients With Melanoma Following the Development of Brain Metastases
Sperduto P, Jiang W, Brown P, Braunstein S, Sneed P, Wattson D, Shih H, Bangdiwala A, Shanley R, Lockney N, Beal K, Lou E, Amatruda T, Sperduto W, Kirkpatrick J, Yeh N, Gaspar L, Molitoris J, Masucci L, Roberge D, Yu J, Chiang V, Mehta M. The Effect of Gene Mutations on Survival in Patients With Melanoma Following the Development of Brain Metastases. International Journal Of Radiation Oncology • Biology • Physics 2016, 96: s178. DOI: 10.1016/j.ijrobp.2016.06.447.Peer-Reviewed Original Research
2015
Prognostic Factors for Seizures After First Radiosurgical Treatment in Patients With Brain Metastases
Jairam V, Chiang V, Yu J. Prognostic Factors for Seizures After First Radiosurgical Treatment in Patients With Brain Metastases. International Journal Of Radiation Oncology • Biology • Physics 2015, 93: e100. DOI: 10.1016/j.ijrobp.2015.07.802.Peer-Reviewed Original ResearchActivity and safety of pembrolizumab in patients with metastatic non-small cell lung cancer with untreated brain metastases.
Goldberg S, Gettinger S, Mahajan A, Herbst R, Chiang A, Tsiouris A, Vortmeyer A, Jilaveanu L, Speaker S, Madura M, Rowen E, Gerrish H, Knapp-Perry E, Yao X, Chiang V, Kluger H. Activity and safety of pembrolizumab in patients with metastatic non-small cell lung cancer with untreated brain metastases. Journal Of Clinical Oncology 2015, 33: 8035-8035. DOI: 10.1200/jco.2015.33.15_suppl.8035.Peer-Reviewed Original Research