2022
Factors associated with progression and mortality among patients undergoing stereotactic radiosurgery for intracranial metastasis: results from a national real-world registry.
Alvi MA, Asher AL, Michalopoulos GD, Grills IS, Warnick RE, McInerney J, Chiang VL, Attia A, Timmerman R, Chang E, Kavanagh BD, Andrews DW, Walter K, Bydon M, Sheehan JP. Factors associated with progression and mortality among patients undergoing stereotactic radiosurgery for intracranial metastasis: results from a national real-world registry. Journal Of Neurosurgery 2022, 137: 985-998. PMID: 35171833, DOI: 10.3171/2021.10.jns211410.Peer-Reviewed Original ResearchMultivariable Cox proportional hazards analysisCox proportional hazards analysisAdministration of immunotherapyProportional hazards analysisStereotactic radiosurgeryIntracranial metastatic lesionsMetastatic lesionsOverall progressionLesion responseInitial stereotactic radiosurgeryMultifraction stereotactic radiosurgeryProgressive intracranial diseaseNeuro-Oncology criteriaOutcomes of patientsReal-world registryResponse Evaluation CriteriaGood local controlIntracranial metastatic diseaseKaplan-Meier analysisCommon primary tumorHazard of progressionLarger lesion sizeSingle-fraction treatmentLesion regressionMedian survival
2019
Initial SRS for Patients With 5 to 15 Brain Metastases: Results of a Multi-Institutional Experience
Hughes RT, Masters AH, McTyre ER, Farris MK, Chung C, Page BR, Kleinberg LR, Hepel J, Contessa JN, Chiang V, Ruiz J, Watabe K, Su J, Fiveash JB, Braunstein S, Chao S, Attia A, Ayala-Peacock DN, Chan MD. Initial SRS for Patients With 5 to 15 Brain Metastases: Results of a Multi-Institutional Experience. International Journal Of Radiation Oncology • Biology • Physics 2019, 104: 1091-1098. PMID: 30959122, DOI: 10.1016/j.ijrobp.2019.03.052.Peer-Reviewed Original ResearchConceptsDistant brain failureInitial stereotactic radiosurgerySalvage whole brain radiation therapyWhole-brain radiation therapySalvage stereotactic radiosurgeryBrain metastasesBrain radiation therapyOverall survivalStereotactic radiosurgeryBM groupCumulative incidenceRadiation therapyNumber of BMTwo-year cumulative incidenceMultivariable Cox proportional hazardsBrain metastasis velocityMedian overall survivalOutcomes of patientsKaplan-Meier methodLog-rank testMulti-institutional experienceRisk regression modelingCox proportional hazardsMultivariable analysisNew metastases
2006
Prognostic factors for survival after stereotactic radiosurgery vary with the number of cerebral metastases
DiLuna ML, King JT, Knisely JP, Chiang VL. Prognostic factors for survival after stereotactic radiosurgery vary with the number of cerebral metastases. Cancer 2006, 109: 135-145. PMID: 17133440, DOI: 10.1002/cncr.22367.Peer-Reviewed Original ResearchConceptsSubgroup of patientsStereotactic radiosurgeryBreast cancerGamma Knife stereotactic radiosurgeryNonsmall cell lung carcinomaCommon tumor histologyInitial stereotactic radiosurgeryWhole brain radiationConnecticut Tumor RegistryMultivariate survival analysisTotal tumor volumeCell lung carcinomaBrain metastasesCerebral metastasesMedian survivalMetastasis locationMedian agePrognostic factorsTumor RegistryTumor histologyIntracranial metastasesPatient populationEsophageal cancerIndependent associationLung carcinoma