The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis
Herman MA, Samuel VT. The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis. Trends In Endocrinology And Metabolism 2016, 27: 719-730. PMID: 27387598, PMCID: PMC5035631, DOI: 10.1016/j.tem.2016.06.005.Peer-Reviewed Original ResearchConceptsFructose consumptionHepatic fructose metabolismHepatic insulin resistanceImpairment of insulinDe novo lipogenesisHepatic steatosisInsulin resistanceEpidemiological studiesNovo lipogenesisMetabolic diseasesFructose metabolismLipogenic enzymesLipogenesisFatty acid synthesisKey transcription factorDiseaseAldolase BLipid synthesisAdditional mechanismHypertriglyceridemiaSteatosisTranscription factorsTherapyInsulinImpairment