Association between sclerostin and bone density in chronic spinal cord injury
Morse L, Sudhakar S, Danilack V, Tun C, Lazzari A, Gagnon D, Garshick E, Battaglino R. Association between sclerostin and bone density in chronic spinal cord injury. Journal Of Bone And Mineral Research 2011, 27: 352-359. PMID: 22006831, PMCID: PMC3288145, DOI: 10.1002/jbmr.546.Peer-Reviewed Original ResearchConceptsChronic spinal cord injurySpinal cord injuryHigher sclerostin levelsSclerostin levelsBone lossCord injuryMechanical unloadingBone densityRodent modelsComplete spinal cord injuryOngoing bone lossParalyzed lower extremitiesBone formationLevels of sclerostinProfound bone lossBone mineral contentGood therapeutic targetChronic paraplegiaMuscle paralysisLower extremitiesOsteoporosis severityShort-term studiesTherapeutic targetAnimal modelsSclerostin