2021
The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiation
Carley E, Stewart R, Zieman AG, Jalilian I, King DE, Zubek AE, Lin S, Horsley V, King MC. The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiation. ELife 2021, 10: e58541. PMID: 33779546, PMCID: PMC8051949, DOI: 10.7554/elife.58541.Peer-Reviewed Original ResearchConceptsCell fateEpidermal cell fateLinker of nucleoskeletonCell fate decisionsEpidermal differentiation genesEpidermal differentiationDirect force transmissionEpidermal stem cellsCytoskeleton (LINC) complexLINC complexFate decisionsNuclear laminaType laminsDifferentiation genesIntegrin engagementForce transductionDifferentiation concomitantChemical signalsMechanotransduction pathwaysKeratinocyte progenitorsMolecular biosensorsStem cellsKeratinocyte differentiationDifferentiationMechanical input
2015
Edges of human embryonic stem cell colonies display distinct mechanical properties and differentiation potential
Rosowski KA, Mertz AF, Norcross S, Dufresne ER, Horsley V. Edges of human embryonic stem cell colonies display distinct mechanical properties and differentiation potential. Scientific Reports 2015, 5: 14218. PMID: 26391588, PMCID: PMC4585749, DOI: 10.1038/srep14218.Peer-Reviewed Original ResearchConceptsHuman embryonic stem cellsUndifferentiated coloniesDifferentiation processCell fate decisionsHuman embryonic stem cell coloniesEmbryonic stem cell coloniesEmbryonic stem cellsEdges of coloniesStrong traction forcesStem cell coloniesEarly human developmentDevelopmental decisionsFate decisionsActin organizationLive imagingColony geometryMyosin activityCellular environmentSmall coloniesAdherent coloniesDifferentiation potentialCell coloniesDifferentiation efficiencyStem cellsColonies
2011
Upward bound: follicular stem cell fate decisions
Horsley V. Upward bound: follicular stem cell fate decisions. The EMBO Journal 2011, 30: 2986-2987. PMID: 21811300, PMCID: PMC3160195, DOI: 10.1038/emboj.2011.231.Peer-Reviewed Original Research