2015
Transcriptional Profiling of Ectoderm Specification to Keratinocyte Fate in Human Embryonic Stem Cells
Tadeu AM, Lin S, Hou L, Chung L, Zhong M, Zhao H, Horsley V. Transcriptional Profiling of Ectoderm Specification to Keratinocyte Fate in Human Embryonic Stem Cells. PLOS ONE 2015, 10: e0122493. PMID: 25849374, PMCID: PMC4388500, DOI: 10.1371/journal.pone.0122493.Peer-Reviewed Original ResearchConceptsHuman embryonic stem cellsEmbryonic stem cellsEctoderm specificationStem cellsHuman embryonic stem cell differentiationEmbryonic stem cell differentiationStem cell differentiationKeratinocyte fateEctoderm lineageEpidermal specificationTranscriptional regulationCandidate regulatorsTranscriptional profilingEpidermal developmentGrowth factor activityProtein aP2Keratinocyte developmentCell differentiationΓ-secretase inhibitor DAPTGenesFactor activityHomeostatic conditionsEpithelial tissuesInhibitor DAPTCell signature
2014
Developing stratified epithelia: lessons from the epidermis and thymus
Roberts N, Horsley V. Developing stratified epithelia: lessons from the epidermis and thymus. WIREs Mechanisms Of Disease 2014, 3: 389-402. PMID: 25176390, PMCID: PMC4283209, DOI: 10.1002/wdev.146.Peer-Reviewed Original ResearchConceptsSelf-restricted T cellsSkin epidermisNumber of organsSquamous epithelial cellsThymic epitheliumT cellsForeign pathogensMulti-layered epitheliumHair folliclesProgenitor cellsEpithelial cellsThymusEpithelial differentiation programEpitheliumStratified epitheliumEpithelial tissuesMolecular mechanismsEpidermisDifferentiation programTissueCellsNegative selectionEmbryonic germ layers
2012
Cadherin-based intercellular adhesions organize epithelial cell–matrix traction forces
Mertz AF, Che Y, Banerjee S, Goldstein JM, Rosowski KA, Revilla SF, Niessen CM, Marchetti MC, Dufresne ER, Horsley V. Cadherin-based intercellular adhesions organize epithelial cell–matrix traction forces. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 110: 842-847. PMID: 23277553, PMCID: PMC3549115, DOI: 10.1073/pnas.1217279110.Peer-Reviewed Original ResearchConceptsCell-cell adhesionExtracellular matrixIntercellular adhesionCell-matrix adhesionImportance of cadherinPrimary mouse keratinocytesTraction forceMechanical regulationFunction of tissuesCadherinColony peripheryCadherin expressionMinimal physical modelCross talkEssential roleMouse keratinocytesEpithelial tissuesEpithelial cellsContractile cellsPhysical cohesionSpatial rearrangementCellsColoniesAdhesionAdhesion type
2008
More than one way to skin . . .
Fuchs E, Horsley V. More than one way to skin . . . Genes & Development 2008, 22: 976-985. PMID: 18413712, PMCID: PMC2732395, DOI: 10.1101/gad.1645908.Peer-Reviewed Original ResearchConceptsStem cellsMultiple signaling networksNormal tissue homeostasisStem cell nicheStem cell populationResident stem cellsEpithelial-mesenchymal interactionsCell populationsCell fateSignaling networksSpecific lineagesTissue homeostasisCell nicheEpithelial stem cellsEpithelial lineageRecent cluesNormal homeostasisEpithelial tissuesLineagesWound repairHomeostasisCellsHair folliclesNicheFate
2007
Epithelial Stem Cells: Turning over New Leaves
Blanpain C, Horsley V, Fuchs E. Epithelial Stem Cells: Turning over New Leaves. Cell 2007, 128: 445-458. PMID: 17289566, PMCID: PMC2408375, DOI: 10.1016/j.cell.2007.01.014.Peer-Reviewed Original ResearchConceptsEpithelial stem cell maintenanceStem cell maintenanceEpithelial stem cell biologyStem cell biologyStem cellsUnipotent progenitor cellsCommon signaling pathwaysEpithelial-mesenchymal interactionsMultipotent stem cellsMost epithelial tissuesLineage determinationCell maintenanceCell biologyNew leavesEpithelial stem cellsSignaling pathwaysHuman disordersHuman diseasesFunctional differencesProgenitor cellsEpithelial tissuesRegenerative medicineMajor clinical implicationsPathwayCells