2022
Probing the rules of cell coordination in live tissues by interpretable machine learning based on graph neural networks
Yamamoto T, Cockburn K, Greco V, Kawaguchi K. Probing the rules of cell coordination in live tissues by interpretable machine learning based on graph neural networks. PLOS Computational Biology 2022, 18: e1010477. PMID: 36067226, PMCID: PMC9481156, DOI: 10.1371/journal.pcbi.1010477.Peer-Reviewed Original Research
2020
Cell-Cycle-Dependent ERK Signaling Dynamics Direct Fate Specification in the Mammalian Preimplantation Embryo
Pokrass MJ, Ryan KA, Xin T, Pielstick B, Timp W, Greco V, Regot S. Cell-Cycle-Dependent ERK Signaling Dynamics Direct Fate Specification in the Mammalian Preimplantation Embryo. Developmental Cell 2020, 55: 328-340.e5. PMID: 33091369, PMCID: PMC7658051, DOI: 10.1016/j.devcel.2020.09.013.Peer-Reviewed Original ResearchConceptsFate specificationPreimplantation developmentKinase translocation reporterMammalian preimplantation embryosInner cell massEmbryonic stem cellsSingle cellsDifferent cell typesMulticellular organismsEndogenous taggingDaughter cellsNanog proteinActive ERKNanog levelsERK activityGene expressionPreimplantation embryosCell cycleTrophectoderm cellsERK inhibitionCell typesStem cellsLive embryosCell massEmbryos