2024
The art of observation: bridging science and art to see the unexpected
Gonzalez L, Wei H, Greco V, Friedlaender L. The art of observation: bridging science and art to see the unexpected. Development 2024, 151 PMID: 38477686, DOI: 10.1242/dev.202786.Peer-Reviewed Original Research
2022
A group approach to growing as a principal investigator
Greco V, Politi K, Eisenbarth S, Colón-Ramos D, Giraldez AJ, Bewersdorf J, Berg DN. A group approach to growing as a principal investigator. Current Biology 2022, 32: r498-r504. PMID: 35671717, DOI: 10.1016/j.cub.2022.04.082.Commentaries, Editorials and Letters
2020
Cell-Cycle-Dependent ERK Signaling Dynamics Direct Fate Specification in the Mammalian Preimplantation Embryo
Pokrass MJ, Ryan KA, Xin T, Pielstick B, Timp W, Greco V, Regot S. Cell-Cycle-Dependent ERK Signaling Dynamics Direct Fate Specification in the Mammalian Preimplantation Embryo. Developmental Cell 2020, 55: 328-340.e5. PMID: 33091369, PMCID: PMC7658051, DOI: 10.1016/j.devcel.2020.09.013.Peer-Reviewed Original ResearchConceptsFate specificationPreimplantation developmentKinase translocation reporterMammalian preimplantation embryosInner cell massEmbryonic stem cellsSingle cellsDifferent cell typesMulticellular organismsEndogenous taggingDaughter cellsNanog proteinActive ERKNanog levelsERK activityGene expressionPreimplantation embryosCell cycleTrophectoderm cellsERK inhibitionCell typesStem cellsLive embryosCell massEmbryos
2019
Flexibility sustains epithelial tissue homeostasis
Tai K, Cockburn K, Greco V. Flexibility sustains epithelial tissue homeostasis. Current Opinion In Cell Biology 2019, 60: 84-91. PMID: 31153058, PMCID: PMC6756930, DOI: 10.1016/j.ceb.2019.04.009.Peer-Reviewed Original ResearchConceptsEpithelial homeostasisEpithelial tissue homeostasisLive-imaging techniquesEpithelial cell interactionsIndividual epithelial cellsOrganism's lifetimeTissue homeostasisCell plasticityCell biologyMolecular mechanismsPathological settingsCell interactionsHomeostasisEpithelial cellsRecent advancesGeneticsBiologyMutationsImportant implicationsEpitheliumMechanismPlasticityCells
2018
Peptides derived from the histidine–proline rich glycoprotein bind copper ions and exhibit anti-angiogenic properties
Magrì A, Grasso G, Corti F, Finetti F, Greco V, Santoro AM, Sciuto S, La Mendola D, Morbidelli L, Rizzarelli E. Peptides derived from the histidine–proline rich glycoprotein bind copper ions and exhibit anti-angiogenic properties. Dalton Transactions 2018, 47: 9492-9503. PMID: 29963662, DOI: 10.1039/c8dt01560k.Peer-Reviewed Original ResearchConceptsElectron paramagnetic resonanceCircular dichroismSpray ionization mass spectrometryPotential drug delivery systemElectron spray ionization mass spectrometryMeans of potentiometryIonization mass spectrometryDrug delivery systemsAmidic bondCopper ionsRole of copperParamagnetic resonanceMass spectrometryComplex speciesTrehalose derivativesProdrug systemEnzymatic degradationDelivery systemCopperPeptidesPotentiometryBondsUVSpectrometryDichroism
2016
Preclinical Advances with Multiphoton Microscopy in Live Imaging of Skin Cancers
Sun TY, Haberman AM, Greco V. Preclinical Advances with Multiphoton Microscopy in Live Imaging of Skin Cancers. Journal Of Investigative Dermatology 2016, 137: 282-287. PMID: 27847119, PMCID: PMC5258832, DOI: 10.1016/j.jid.2016.08.033.Peer-Reviewed Original ResearchThe thrill of scientific discovery and leadership with my group
Greco V. The thrill of scientific discovery and leadership with my group. Molecular Biology Of The Cell 2016, 27: 3185-3188. PMID: 27799490, PMCID: PMC5170847, DOI: 10.1091/mbc.e16-06-0373.Peer-Reviewed Original ResearchLive imaging of stem cells: answering old questions and raising new ones
Park S, Greco V, Cockburn K. Live imaging of stem cells: answering old questions and raising new ones. Current Opinion In Cell Biology 2016, 43: 30-37. PMID: 27474806, PMCID: PMC5154884, DOI: 10.1016/j.ceb.2016.07.004.Peer-Reviewed Original ResearchHardwiring Stem Cell Communication through Tissue Structure
Xin T, Greco V, Myung P. Hardwiring Stem Cell Communication through Tissue Structure. Cell 2016, 164: 1212-1225. PMID: 26967287, PMCID: PMC4805424, DOI: 10.1016/j.cell.2016.02.041.Peer-Reviewed Original Research
2015
Translational Downregulation of HSP90 Expression by Iron Chelators in Neuroblastoma Cells
Sidarovich V, Adami V, Gatto P, Greco V, Tebaldi T, Tonini GP, Quattrone A. Translational Downregulation of HSP90 Expression by Iron Chelators in Neuroblastoma Cells. Molecular Pharmacology 2015, 87: 513-524. PMID: 25564462, DOI: 10.1124/mol.114.095729.Peer-Reviewed Original ResearchConceptsTranslational downregulationHeat shock protein groupIntracellular ironIron chelatorsG0/G1 cell cycle blockCell linesG1 cell cycle blockCombined transcriptomeInduction of apoptosisTranslatome profilingClient proteinsCell cycle blockCell viabilityInvestigational antitumor agentNB cell linesCellular nutrientsHsp90 inhibitionNeuroblastoma cell linesProtein groupsCPX treatmentCell growthNB therapyAchievable concentrationsCycle blockInhibition of growth
2014
Stem Cells in the Wild: Understanding the World of Stem Cells through Intravital Imaging
Brown S, Greco V. Stem Cells in the Wild: Understanding the World of Stem Cells through Intravital Imaging. Cell Stem Cell 2014, 15: 683-686. PMID: 25479745, PMCID: PMC4623825, DOI: 10.1016/j.stem.2014.11.006.Peer-Reviewed Original ResearchValentina Greco: Got hair?
Greco V, Sedwick C. Valentina Greco: Got hair? Journal Of Cell Biology 2014, 207: 436-437. PMID: 25422370, PMCID: PMC4242828, DOI: 10.1083/jcb.2074pi.Peer-Reviewed Original ResearchEstablishing an academic laboratory: mentoring as a business model
Greco V. Establishing an academic laboratory: mentoring as a business model. Molecular Biology Of The Cell 2014, 25: 3251-3253. PMID: 25360043, PMCID: PMC4214767, DOI: 10.1091/mbc.e14-06-1079.Peer-Reviewed Original Research
2013
Stem cell dynamics in the hair follicle niche
Rompolas P, Greco V. Stem cell dynamics in the hair follicle niche. Seminars In Cell And Developmental Biology 2013, 25: 34-42. PMID: 24361866, PMCID: PMC3988239, DOI: 10.1016/j.semcdb.2013.12.005.Peer-Reviewed Original ResearchConceptsHair follicle nicheStem cellsStem cell behaviorMouse genetic modelsNon-cellular componentsNiche microenvironmentMolecular signalsCell behaviorNicheMammalian skinHair folliclesProcess of regenerationCell dynamicsCell populationsGenetic modelsExtracellular materialCurrent understandingCellular compositionTissue regenerationCellsRegenerationNew hairAppendagesMicroenvironmentFollicles
2010
Compartmentalized organization: a common and required feature of stem cell niches?
Greco V, Guo S. Compartmentalized organization: a common and required feature of stem cell niches? Development 2010, 137: 1586-1594. PMID: 20430743, PMCID: PMC2860245, DOI: 10.1242/dev.041103.Peer-Reviewed Original ResearchConceptsStem cell nicheCell nicheHair follicle stem cell nicheFollicle stem cell nicheAdult stem cell nichesStem cellsStem cell fieldOrgan growthNicheHair regenerationSlow cyclingRecent findingsCell fieldNew growthTissue regenerationRecent studiesCellsGrowthLong-term growthRegenerationProgenyCompartmentsKey questions
1997
DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function.
Di Leonardo A, Khan SH, Linke SP, Greco V, Seidita G, Wahl GM. DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function. Cancer Research 1997, 57: 1013-9. PMID: 9067261.Peer-Reviewed Original ResearchConceptsDNA rereplicationBiochemical signal transduction pathwaysSignal transduction pathwaysCell cycle checkpointsPRb tumor suppressorSpindle assemblyCycle checkpointsTransduction pathwaysRereplicationDownstream eventsMitotic divisionTumor suppressorMouse fibroblastsCell ploidyDNA contentDeficient derivativeHuman fibroblastsSpindle inhibitorsP53Cytogenetic analysisMitotic spindle inhibitorsFibroblastsPolyploidyMitosisSuppressor