2021
Skin-resident immune cells actively coordinate their distribution with epidermal cells during homeostasis
Park S, Matte-Martone C, Gonzalez DG, Lathrop EA, May DP, Pineda CM, Moore JL, Boucher JD, Marsh E, Schmitter-Sánchez A, Cockburn K, Markova O, Bellaïche Y, Greco V. Skin-resident immune cells actively coordinate their distribution with epidermal cells during homeostasis. Nature Cell Biology 2021, 23: 476-484. PMID: 33958758, PMCID: PMC8603572, DOI: 10.1038/s41556-021-00670-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEpidermal CellsEpidermisHomeostasisIntercellular JunctionsMice, TransgenicSkinT-LymphocytesConceptsDendritic epidermal T cellsLangerhans cellsCell typesEpithelial cellsDifferent cell typesMultiple cell typesLive adult miceGTPase Rac1Skin-resident immune cellsNon-random spatial distributionDistribution of LCContinuous turnoverEpidermal cellsEpidermal T cellsIndividual cellsCellular mechanismsEnvironmental insultsHomeostasisBasal epithelial cellsImmune cellsT cellsAdult miceCellsProper architectureEpidermis
2019
Flexibility sustains epithelial tissue homeostasis
Tai K, Cockburn K, Greco V. Flexibility sustains epithelial tissue homeostasis. Current Opinion In Cell Biology 2019, 60: 84-91. PMID: 31153058, PMCID: PMC6756930, DOI: 10.1016/j.ceb.2019.04.009.Peer-Reviewed Original ResearchConceptsEpithelial homeostasisEpithelial tissue homeostasisLive-imaging techniquesEpithelial cell interactionsIndividual epithelial cellsOrganism's lifetimeTissue homeostasisCell plasticityCell biologyMolecular mechanismsPathological settingsCell interactionsHomeostasisEpithelial cellsRecent advancesGeneticsBiologyMutationsImportant implicationsEpitheliumMechanismPlasticityCells
2018
Flexible fate determination ensures robust differentiation in the hair follicle
Xin T, Gonzalez D, Rompolas P, Greco V. Flexible fate determination ensures robust differentiation in the hair follicle. Nature Cell Biology 2018, 20: 1361-1369. PMID: 30420661, PMCID: PMC6314017, DOI: 10.1038/s41556-018-0232-y.Peer-Reviewed Original ResearchConceptsSingle-cell levelStem cellsStem cell differentiationGerm stem cellsTissue architectureMultiple cell typesFate determinationDetermination mechanismTissue homeostasisSame stem cellsCommon progenitorDifferentiation outcomesDifferentiation stimuliDifferentiation lineageCell differentiationCell typesNormal differentiationWnt activationHair folliclesUnanticipated flexibilityDifferentiationRobust differentiationProgenitorsCellsUninjured conditionPositional Stability and Membrane Occupancy Define Skin Fibroblast Homeostasis In Vivo
Marsh E, Gonzalez DG, Lathrop EA, Boucher J, Greco V. Positional Stability and Membrane Occupancy Define Skin Fibroblast Homeostasis In Vivo. Cell 2018, 175: 1620-1633.e13. PMID: 30415836, PMCID: PMC7605015, DOI: 10.1016/j.cell.2018.10.013.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell MembraneCell NucleusCells, CulturedFibroblastsHomeostasisMiceMice, TransgenicSkinConceptsCore cellular mechanismsFibroblast homeostasisRac1-dependent mannerNeighboring fibroblastsMembrane occupancyMembrane extensionsNucleus organizationCellular mechanismsHomeostasisFibroblast membranesAbsence of migrationFibroblastsCell occupancySkin fibroblastsProgressive accumulationVivoStructural componentsLifespan of miceLive miceOccupancyMicePositional stabilityMembraneLifespanAccumulationHomeostatic Epidermal Stem Cell Self-Renewal Is Driven by Local Differentiation
Mesa KR, Kawaguchi K, Cockburn K, Gonzalez D, Boucher J, Xin T, Klein AM, Greco V. Homeostatic Epidermal Stem Cell Self-Renewal Is Driven by Local Differentiation. Cell Stem Cell 2018, 23: 677-686.e4. PMID: 30269903, PMCID: PMC6214709, DOI: 10.1016/j.stem.2018.09.005.Peer-Reviewed Original Research
2017
Correction of aberrant growth preserves tissue homeostasis
Brown S, Pineda CM, Xin T, Boucher J, Suozzi KC, Park S, Matte-Martone C, Gonzalez DG, Rytlewski J, Beronja S, Greco V. Correction of aberrant growth preserves tissue homeostasis. Nature 2017, 548: 334-337. PMID: 28783732, PMCID: PMC5675114, DOI: 10.1038/nature23304.Peer-Reviewed Original Research
2016
Spatiotemporal coordination of stem cell commitment during epidermal homeostasis
Rompolas P, Mesa KR, Kawaguchi K, Park S, Gonzalez D, Brown S, Boucher J, Klein AM, Greco V. Spatiotemporal coordination of stem cell commitment during epidermal homeostasis. Science 2016, 352: 1471-1474. PMID: 27229141, PMCID: PMC4958018, DOI: 10.1126/science.aaf7012.Peer-Reviewed Original ResearchHardwiring Stem Cell Communication through Tissue Structure
Xin T, Greco V, Myung P. Hardwiring Stem Cell Communication through Tissue Structure. Cell 2016, 164: 1212-1225. PMID: 26967287, PMCID: PMC4805424, DOI: 10.1016/j.cell.2016.02.041.Peer-Reviewed Original Research
2015
Niche-induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool
Mesa KR, Rompolas P, Zito G, Myung P, Sun TY, Brown S, Gonzalez DG, Blagoev KB, Haberman AM, Greco V. Niche-induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool. Nature 2015, 522: 94-97. PMID: 25849774, PMCID: PMC4457634, DOI: 10.1038/nature14306.Peer-Reviewed Original Research