2023
Injury prevents Ras mutant cell expansion in mosaic skin
Gallini S, Annusver K, Rahman N, Gonzalez D, Yun S, Matte-Martone C, Xin T, Lathrop E, Suozzi K, Kasper M, Greco V. Injury prevents Ras mutant cell expansion in mosaic skin. Nature 2023, 619: 167-175. PMID: 37344586, PMCID: PMC10322723, DOI: 10.1038/s41586-023-06198-y.Peer-Reviewed Original ResearchMeSH KeywordsCell CycleCell ProliferationCyclin-Dependent Kinase Inhibitor p21ErbB ReceptorsGenes, rasMosaicismMutationRas ProteinsSkinConceptsWild-type cellsRas family proteinsCell cycle inhibitor p21Family proteinsOncogenic RasGenetic approachesMosaic tissuesInhibition of EGFRInhibitor p21EGFR ligandsEGFR pathwayCell expansionAberrant growthConstitutive lossDifferential activationParacrine secretionAbsence of injuryCellsCompetitive balanceInjury repairHealthy skinInjurySkinProteinPathway
2016
Preclinical Advances with Multiphoton Microscopy in Live Imaging of Skin Cancers
Sun TY, Haberman AM, Greco V. Preclinical Advances with Multiphoton Microscopy in Live Imaging of Skin Cancers. Journal Of Investigative Dermatology 2016, 137: 282-287. PMID: 27847119, PMCID: PMC5258832, DOI: 10.1016/j.jid.2016.08.033.Peer-Reviewed Original ResearchMeSH KeywordsCell ProliferationHumansMicroscopy, Fluorescence, MultiphotonNeoplasm InvasivenessNeoplasm MetastasisSkin NeoplasmsLive imaging of stem cells: answering old questions and raising new ones
Park S, Greco V, Cockburn K. Live imaging of stem cells: answering old questions and raising new ones. Current Opinion In Cell Biology 2016, 43: 30-37. PMID: 27474806, PMCID: PMC5154884, DOI: 10.1016/j.ceb.2016.07.004.Peer-Reviewed Original Research
2015
Intravital imaging of hair follicle regeneration in the mouse
Pineda CM, Park S, Mesa KR, Wolfel M, Gonzalez DG, Haberman AM, Rompolas P, Greco V. Intravital imaging of hair follicle regeneration in the mouse. Nature Protocols 2015, 10: 1116-1130. PMID: 26110716, PMCID: PMC4632978, DOI: 10.1038/nprot.2015.070.Peer-Reviewed Original ResearchTranslational Downregulation of HSP90 Expression by Iron Chelators in Neuroblastoma Cells
Sidarovich V, Adami V, Gatto P, Greco V, Tebaldi T, Tonini GP, Quattrone A. Translational Downregulation of HSP90 Expression by Iron Chelators in Neuroblastoma Cells. Molecular Pharmacology 2015, 87: 513-524. PMID: 25564462, DOI: 10.1124/mol.114.095729.Peer-Reviewed Original ResearchConceptsTranslational downregulationHeat shock protein groupIntracellular ironIron chelatorsG0/G1 cell cycle blockCell linesG1 cell cycle blockCombined transcriptomeInduction of apoptosisTranslatome profilingClient proteinsCell cycle blockCell viabilityInvestigational antitumor agentNB cell linesCellular nutrientsHsp90 inhibitionNeuroblastoma cell linesProtein groupsCPX treatmentCell growthNB therapyAchievable concentrationsCycle blockInhibition of growth