Translational Downregulation of HSP90 Expression by Iron Chelators in Neuroblastoma Cells
Sidarovich V, Adami V, Gatto P, Greco V, Tebaldi T, Tonini GP, Quattrone A. Translational Downregulation of HSP90 Expression by Iron Chelators in Neuroblastoma Cells. Molecular Pharmacology 2015, 87: 513-524. PMID: 25564462, DOI: 10.1124/mol.114.095729.Peer-Reviewed Original ResearchConceptsTranslational downregulationHeat shock protein groupIntracellular ironIron chelatorsG0/G1 cell cycle blockCell linesG1 cell cycle blockCombined transcriptomeInduction of apoptosisTranslatome profilingClient proteinsCell cycle blockCell viabilityInvestigational antitumor agentNB cell linesCellular nutrientsHsp90 inhibitionNeuroblastoma cell linesProtein groupsCPX treatmentCell growthNB therapyAchievable concentrationsCycle blockInhibition of growth