2023
Injury prevents Ras mutant cell expansion in mosaic skin
Gallini S, Annusver K, Rahman N, Gonzalez D, Yun S, Matte-Martone C, Xin T, Lathrop E, Suozzi K, Kasper M, Greco V. Injury prevents Ras mutant cell expansion in mosaic skin. Nature 2023, 619: 167-175. PMID: 37344586, PMCID: PMC10322723, DOI: 10.1038/s41586-023-06198-y.Peer-Reviewed Original ResearchConceptsWild-type cellsRas family proteinsCell cycle inhibitor p21Family proteinsOncogenic RasGenetic approachesMosaic tissuesInhibition of EGFRInhibitor p21EGFR ligandsEGFR pathwayCell expansionAberrant growthConstitutive lossDifferential activationParacrine secretionAbsence of injuryCellsCompetitive balanceInjury repairHealthy skinInjurySkinProteinPathway
2003
Defining the Epithelial Stem Cell Niche in Skin
Tumbar T, Guasch G, Greco V, Blanpain C, Lowry WE, Rendl M, Fuchs E. Defining the Epithelial Stem Cell Niche in Skin. Science 2003, 303: 359-363. PMID: 14671312, PMCID: PMC2405920, DOI: 10.1126/science.1092436.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell CycleCell DivisionCell SeparationEpidermal CellsEpidermisEpithelial CellsGene Expression ProfilingGene Expression RegulationGreen Fluorescent ProteinsHair FollicleHistonesKeratinocytesLuminescent ProteinsMiceMice, TransgenicMicroscopy, FluorescenceMultipotent Stem CellsOligonucleotide Array Sequence AnalysisReverse Transcriptase Polymerase Chain ReactionRNA, MessengerTranscription, GeneticConceptsStem cell nicheLabel-retaining cellsCell nicheSkin stem cell nichesCell type-specific fashionType-specific fashionEpithelial stem cell nicheTranscriptional profilesSlow-cycling cellsHigh proliferative capacityMessenger RNANicheSurface receptorsProliferative capacityRegenerative cellsCellsRNAProgenyProtein
2001
Argosomes A Potential Vehicle for the Spread of Morphogens through Epithelia
Greco V, Hannus M, Eaton S. Argosomes A Potential Vehicle for the Spread of Morphogens through Epithelia. Cell 2001, 106: 633-645. PMID: 11551510, DOI: 10.1016/s0092-8674(01)00484-6.Peer-Reviewed Original ResearchConceptsWingless proteinFormation of morphogen gradientsImaginal disc epitheliumCell biological mechanismsSpreading of morphogensDisc epitheliumMorphogen gradientsArgosomesTissue patterningMorphogenWinglessMembrane fragmentsCell membraneProteinBiological mechanismsCellsAdjacent tissuesMembraneEndosomesBasolateral membranePotential vehicleTissueFragments