2002
Role of the interleukin-6/interleukin-6 soluble receptor cytokine system in mediating increased skeletal sensitivity to parathyroid hormone in perimenopausal women.
Insogna K, Mitnick M, Pascarella J, Nakchbandi I, Grey A, Masiukiewicz U. Role of the interleukin-6/interleukin-6 soluble receptor cytokine system in mediating increased skeletal sensitivity to parathyroid hormone in perimenopausal women. Journal Of Bone And Mineral Research 2002, 17 Suppl 2: n108-16. PMID: 12412787.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsBone and BonesBone ResorptionCollagenCollagen Type ICytokinesDisease Models, AnimalEstrogensFemaleFollow-Up StudiesHumansHyperparathyroidismInterleukin-6MenopauseMiceMiddle AgedOsteoporosis, PostmenopausalParathyroid HormonePeptidesPostmenopausePredictive Value of TestsPremenopauseReceptors, Interleukin-6Reference ValuesRetrospective StudiesConceptsIL-6/ILInterleukin-6Skeletal sensitivityPerimenopausal periodPrimary hyperparathyroidismPerimenopausal womenCytokine systemInterleukin-6 soluble receptorSerum IL-6 valuesEstrogen-deficient stateUrine N-telopeptideInterleukin-6/interleukinAction of PTHGroup of patientsIL-6 valuesSerum IL-6/ILEstrogen modulatesIL-6sRIL-6sR.Perimenopausal groupUrine NTXPremenopausal womenSkeletal complicationsCytokine profileExaggerated release
1999
A Role for Interleukin-6 in Parathyroid Hormone-Induced Bone Resorption in Vivo1
Grey A, Mitnick M, Masiukiewicz U, Sun B, Rudikoff S, Jilka R, Manolagas S, Insogna K. A Role for Interleukin-6 in Parathyroid Hormone-Induced Bone Resorption in Vivo1. Endocrinology 1999, 140: 4683-4690. DOI: 10.1210/en.140.10.4683.Peer-Reviewed Original ResearchBiochemical markers of bone resorptionMarkers of bone resorptionPTH-induced bone resorptionParathyroid hormoneBone resorptionInterleukin-6Biochemical markersPTH infusionResponse to PTH infusionCirculating levels of interleukin-6Action of PTH in vivoMarkers of bone formationResponse to PTHEffect of parathyroid hormoneLevels of interleukin-6Neutralization of interleukin-6Associated with markedly lower levelsParathyroid hormone-induced bone resorptionPTH in vivoBone resorbing actionPTH-induced changesRelease of calciumInterleukin-6 productionCytokine interleukin-6Paracrine factor(s