2024
Cannabis Exposure and Adverse Pregnancy Outcomes Related to Placental Function
Metz T, Allshouse A, McMillin G, Greene T, Chung J, Grobman W, Haas D, Mercer B, Parry S, Reddy U, Saade G, Simhan H, Silver R. Cannabis Exposure and Adverse Pregnancy Outcomes Related to Placental Function. Obstetric Anesthesia Digest 2024, 44: 139-140. DOI: 10.1097/01.aoa.0001026572.72882.bd.Peer-Reviewed Original ResearchExposure to cannabisCannabis usePlacental functionPregnancy outcomesPrevalence of cannabis usePoor fetal growthAdverse pregnancy outcomesInfluence pregnancy outcomePlacental dysfunctionCannabis exposureFetal growthPregnant individualsSelf-reported useTobacco useCannabisDrug usePregnancyOutcome relationsPotential legal consequencesOutcomesAssociationExposureUseDysfunctionPublished researchCannabis Exposure and Adverse Pregnancy Outcomes Related to Placental Function
Metz T, Allshouse A, McMillin G, Greene T, Chung J, Grobman W, Haas D, Mercer B, Parry S, Reddy U, Saade G, Simhan H, Silver R. Cannabis Exposure and Adverse Pregnancy Outcomes Related to Placental Function. Obstetrical & Gynecological Survey 2024, 79: 307-309. DOI: 10.1097/ogx.0000000000001289.Peer-Reviewed Original Research
2023
Cannabis Exposure and Adverse Pregnancy Outcomes Related to Placental Function
Metz T, Allshouse A, McMillin G, Greene T, Chung J, Grobman W, Haas D, Mercer B, Parry S, Reddy U, Saade G, Simhan H, Silver R. Cannabis Exposure and Adverse Pregnancy Outcomes Related to Placental Function. JAMA 2023, 330: 2191-2199. PMID: 38085313, PMCID: PMC10716715, DOI: 10.1001/jama.2023.21146.Peer-Reviewed Original ResearchConceptsPrimary composite outcomeAdverse pregnancy outcomesComposite outcomeFirst trimesterCannabis exposurePregnancy outcomesCannabis usePlacental functionPropensity score-weighted analysisNulliparous Pregnancy Outcomes StudyOngoing exposureMaternal cannabis useUrine cotinine assayUrine samplesMedical record abstractionPregnancy outcome dataGestational-age birthsBody mass indexGestational age windowsPregnancy Outcomes StudyUS medical centersOngoing cannabis useAdjudication of outcomesMaternal cannabisHypertensive disorders
2017
Onset of human preterm and term birth is related to unique inflammatory transcriptome profiles at the maternal fetal interface
Bukowski R, Sadovsky Y, Goodarzi H, Zhang H, Biggio JR, Varner M, Parry S, Xiao F, Esplin SM, Andrews W, Saade GR, Ilekis JV, Reddy UM, Baldwin DA. Onset of human preterm and term birth is related to unique inflammatory transcriptome profiles at the maternal fetal interface. PeerJ 2017, 5: e3685. PMID: 28879060, PMCID: PMC5582610, DOI: 10.7717/peerj.3685.Peer-Reviewed Original ResearchMaternal-fetal interfacePreterm birthTerm birthsFetal interfaceDownregulation of chemokinesAbsence of laborBurden of diseasePremature deliveryCesarean deliveryOverall mortalityChemokine expressionTerm laborNeonatal mortalityPregnant womenUterine fundusTerm parturitionHuman pretermPlacental functionMaternal bloodMultiple pathwaysFetal bloodPretermExpression profilesImmune rejectionImmune systemAltered fetal growth, placental abnormalities, and stillbirth
Bukowski R, Hansen NI, Pinar H, Willinger M, Reddy UM, Parker CB, Silver RM, Dudley DJ, Stoll BJ, Saade GR, Koch MA, Hogue C, Varner MW, Conway DL, Coustan D, Goldenberg RL, . Altered fetal growth, placental abnormalities, and stillbirth. PLOS ONE 2017, 12: e0182874. PMID: 28820889, PMCID: PMC5562325, DOI: 10.1371/journal.pone.0182874.Peer-Reviewed Original ResearchConceptsFetal growth abnormalitiesAltered fetal growthFetal growthLive birthsPlacental abnormalitiesPlacental findingsGrowth abnormalitiesImpaired placental functionSingleton live birthsCase-control studyCause of deathPatterns of associationSingleton stillbirthsPlacental examinationTerm stillbirthGestational ageRisk factorsPerinatal pathologistsPlacental functionClinical careStillbirthAbnormalitiesStandardized protocolBirthDeath