The value of mutational profiling of the cytocentrifugation supernatant fluid from fine-needle aspiration of pancreatic solid mass lesions
Deftereos G, Finkelstein S, Jackson S, Ellsworth E, Krishnamurti U, Liu Y, Silverman J, Binkert C, Ujevich B, Mohanty A. The value of mutational profiling of the cytocentrifugation supernatant fluid from fine-needle aspiration of pancreatic solid mass lesions. Modern Pathology 2013, 27: 594-601. PMID: 24051700, DOI: 10.1038/modpathol.2013.147.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaBiomarkers, TumorBiopsy, Fine-NeedleCentrifugationDNA Mutational AnalysisDNA, NeoplasmGenetic Predisposition to DiseaseHumansLoss of HeterozygosityMicrodissectionMutationPancreatic NeoplasmsPolymerase Chain ReactionPredictive Value of TestsProto-Oncogene ProteinsProto-Oncogene Proteins p21(ras)Ras ProteinsConceptsFine-needle aspirationPancreatic solid massesDiagnostic yieldSupernatant fluidTumor DNASolid massHigh clinical suspicionDetectable mutationsSolid mass lesionQuantitative PCRClinical suspicionAtypical cellsDefinitive diagnosisMass lesionCytology smearsFluid specimensFNA smearsMolecular analysisAdjunct methodAdequate DNAMutational profilingCell blocksCytocentrifugation supernatant fluidSmearsBroad panel