2021
Risk of lower respiratory tract infections: a genome-wide association study with Mendelian randomization analysis in three independent European populations
Flatby HM, Rasheed H, Ravi A, Thomas LF, Liyanarachi KV, Afset JE, DeWan AT, Brumpton BM, Hveem K, Åsvold BO, Simonsen GS, Furberg AS, Damås JK, Solligård E, Rogne T. Risk of lower respiratory tract infections: a genome-wide association study with Mendelian randomization analysis in three independent European populations. Clinical Microbiology And Infection 2021, 28: 732.e1-732.e7. PMID: 34763054, DOI: 10.1016/j.cmi.2021.11.004.Peer-Reviewed Original ResearchConceptsLower respiratory tract infectionsRespiratory tract infectionsMendelian randomization analysisTract infectionsRisk factorsRisk of LRTICardiometabolic risk factorsSystolic blood pressureTrøndelag Health StudyPrevalence of smokingRandomization analysisBody mass indexCause of morbidityPotential risk factorsBlood pressureMass indexSuch hospitalizationsDisease burdenProtective effectHealth StudyIndependent European populationsLifetime smokingGenome-wide association studiesGenetic susceptibilitySmokingBody mass index and subfertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study
Hernáez Á, Rogne T, Skåra KH, Håberg SE, Page CM, Fraser A, Burgess S, Lawlor DA, Magnus MC. Body mass index and subfertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study. Human Reproduction 2021, 36: 3141-3151. PMID: 34668019, PMCID: PMC8600658, DOI: 10.1093/humrep/deab224.Peer-Reviewed Original ResearchMeSH KeywordsAdultBody Mass IndexChildCohort StudiesFathersFemaleHumansInfertilityMaleMendelian Randomization AnalysisMothersPregnancyConceptsCohort studyBMI valuesMendelian randomization analysisMultivariable regressionGreater oddsMultivariable logistic regression modelSTUDY FUNDING/COMPETINGProject number 262700Risk of subfertilityRandomization analysisBody mass indexChild Cohort StudyPARTICIPANTS/MATERIALSUK National InstituteNational InstituteROLE OF CHANCELogistic regression modelsSelf-reported informationAssisted reproduction technologyObese menObese womenHigher BMILower BMIMass indexUS National Institutes
2020
Body mass index and risk of dying from a bloodstream infection: A Mendelian randomization study
Rogne T, Solligård E, Burgess S, Brumpton BM, Paulsen J, Prescott HC, Mohus RM, Gustad LT, Mehl A, Åsvold BO, DeWan AT, Damås JK. Body mass index and risk of dying from a bloodstream infection: A Mendelian randomization study. PLOS Medicine 2020, 17: e1003413. PMID: 33196656, PMCID: PMC7668585, DOI: 10.1371/journal.pmed.1003413.Peer-Reviewed Original ResearchConceptsBody mass indexHigher body mass indexBloodstream infectionsBSI incidenceBSI mortalityHazard ratioMass indexGeneral populationPopulation-based cohortAnalysis of patientsTerms of mortalityMendelian randomization studyTraditional epidemiological studiesMendelian randomization analysisObesity paradoxMean ageObservational studyEpidemiological studiesRandomization studyCausal associationSepsisMortalityPatientsInfectionRandomization analysisCardiometabolic Traits, Sepsis, and Severe COVID-19
Ponsford MJ, Gkatzionis A, Walker VM, Grant AJ, Wootton RE, Moore LSP, Fatumo S, Mason AM, Zuber V, Willer C, Rasheed H, Brumpton B, Hveem K, Damås J, Davies N, Åsvold BO, Solligård E, Jones S, Burgess S, Rogne T, Gill D. Cardiometabolic Traits, Sepsis, and Severe COVID-19. Circulation 2020, 142: 1791-1793. PMID: 32966752, PMCID: PMC7594537, DOI: 10.1161/circulationaha.120.050753.Peer-Reviewed Original ResearchBetacoronavirusBody Mass IndexCase-Control StudiesCoronavirus InfectionsCOVID-19Diabetes Mellitus, Type 2DyslipidemiasGene-Environment InteractionGenetic Association StudiesGenetic Predisposition to DiseaseHost-Pathogen InteractionsHumansMendelian Randomization AnalysisObesityPandemicsPhenotypePneumonia, ViralPolymorphism, Single NucleotideRisk FactorsSARS-CoV-2SepsisSeverity of Illness IndexSmoking