2003
Inhibition of heme oxygenase decreases sodium and fluid absorption in the loop of Henle
Wang T, Sterling H, Shao WA, Yan Q, Bailey MA, Giebisch G, Wang WH. Inhibition of heme oxygenase decreases sodium and fluid absorption in the loop of Henle. American Journal Of Physiology. Renal Physiology 2003, 285: f484-f490. PMID: 12890663, DOI: 10.1152/ajprenal.00135.2003.Peer-Reviewed Original ResearchMeSH KeywordsAbsorptionAnimalsDietDose-Response Relationship, DrugGene ExpressionHeme Oxygenase (Decyclizing)Loop of HenleMaleMesoporphyrinsPotassiumProtoporphyrinsRatsRats, Sprague-DawleySodiumWaterConceptsLoop of HenleThick ascending limbFluid absorptionRenal sodium excretionGlomerular filtration rateRenal clearance studiesNormal rat chowHO-2 expressionRenal clearance methodsInhibitor of HOWestern blot analysisDecrease sodiumHK ratsSodium excretionChromium mesoporphyrinHO-2Normal chowHK dietFiltration rateRat chowVivo microperfusionResult of inhibitionMicroperfusion experimentsClearance studiesClearance method
1991
The role of phosphoinositide turnover in mediating the biphasic effect of angiotensin II on renal tubular transport.
Wang T, Chan Y. The role of phosphoinositide turnover in mediating the biphasic effect of angiotensin II on renal tubular transport. Journal Of Pharmacology And Experimental Therapeutics 1991, 256: 309-17. PMID: 1846421.Peer-Reviewed Original ResearchMeSH Keywords1-(5-Isoquinolinesulfonyl)-2-MethylpiperazineAngiotensin IIAnimalsBicarbonatesBiological TransportCalcium Channel BlockersDose-Response Relationship, DrugGallic AcidIsoquinolinesKidney Tubules, ProximalMalePerfusionPhosphatidylinositolsPiperazinesProtein Kinase InhibitorsRatsRats, Inbred StrainsSignal TransductionSodiumTetradecanoylphorbol AcetateConceptsM ANG IIAng IIBiphasic effectAngiotensin IIM TMBDose-dependent biphasic effectSodium transportPhosphoinositide turnoverIntracellular calcium mobilizationRenal tubular transportOriginal perfusateRat PCTLuminal perfusionCalcium mobilizationTubular transportFluid reabsorptionRat kidneyStimulatory effectJHCO3Total CO2 changesVolume markerRinger's solutionPossible roleCritical rolePrevious studies
1990
Mechanism of angiotensin II action on proximal tubular transport.
Wang T, Chan Y. Mechanism of angiotensin II action on proximal tubular transport. Journal Of Pharmacology And Experimental Therapeutics 1990, 252: 689-95. PMID: 2313594.Peer-Reviewed Original ResearchMeSH KeywordsAmilorideAngiotensin IIAnimalsBiological TransportDose-Response Relationship, DrugKidney Tubules, ProximalMaleProtein Kinase CRatsRats, Inbred StrainsSodiumTetradecanoylphorbol AcetateConceptsAng II actionFluid reabsorptionAng IILuminal perfusionAng II interactsAction of angiotensinAng II antagonistAngiotensin II actionM ANG IIPhosphoinositide turnoverProximal tubular transportRat proximal tubuleNa-H exchange mechanismOriginal perfusateRat PCTAngiotensin IIII antagonistLow dosePCT transportTubular transportProximal tubulesBicarbonate absorptionM amilorideStimulatory effectTotal CO2 changes