2023
High dietary K+ intake inhibits proximal tubule transport
Wang T, Liu T, Xu S, Frindt G, Weinstein A, Palmer L. High dietary K+ intake inhibits proximal tubule transport. American Journal Of Physiology. Renal Physiology 2023, 325: f224-f234. PMID: 37318989, PMCID: PMC10396284, DOI: 10.1152/ajprenal.00013.2023.Peer-Reviewed Original ResearchConceptsGlomerular filtration rateFree-flow micropunctureFiltration rateUrine volumeFractional NaNephron segmentsOverall kidney functionProximal tubule transportProximal tubule functionNHE3 protein expressionExchanger isoform 3HK animalsKCl dietFraction excretionKidney functionHigh dietaryTubule functionKidney microsomesTubule transportAnesthetized animalsProximal tubulesVolume reabsorptionExcretionWestern blotControl diet
2017
Regulation of glomerulotubular balance: flow-activated proximal tubule function
Wang T, Weinbaum S, Weinstein AM. Regulation of glomerulotubular balance: flow-activated proximal tubule function. Pflügers Archiv - European Journal Of Physiology 2017, 469: 643-654. PMID: 28271233, PMCID: PMC6162058, DOI: 10.1007/s00424-017-1960-8.Peer-Reviewed Original Research
1998
Tubule Function in Transgenic Mice
Wang T, Giebisch G. Tubule Function in Transgenic Mice. Experimental Nephrology 1998, 6: 447-453. PMID: 9730661, DOI: 10.1159/000020554.Peer-Reviewed Original ResearchConceptsRenal tubule transportRenal electrolyte transportStrains of miceExchanger isoforms NHE2Renal transport functionsK-ATPase expressionMouse modelTubule functionTransgenic knockoutTubule transportTransgenic miceExchanger isoforms NHE1MiceTubule segmentsSelective alterationsOverexpression modelElectrolyte transportTransport functionKnockout modelsLesionsKidneyIsoforms NHE1
1995
Effects of a novel KATP channel blocker on renal tubule function and K channel activity.
Wang T, Wang W, Klein-Robbenhaar G, Giebisch G. Effects of a novel KATP channel blocker on renal tubule function and K channel activity. Journal Of Pharmacology And Experimental Therapeutics 1995, 273: 1382-9. PMID: 7791111.Peer-Reviewed Original ResearchConceptsKATP channel blockerLoop of HenleCortical collecting tubuleThick ascending limbPotassium secretionChannel blockersCollecting tubuleAscending limbPotassium recyclingRenal tubule functionK channel activitySodium reabsorptionTubule functionCl reabsorptionK secretionPotassium conductanceApical potassium conductancePrincipal cellsSecretionChannel activityBlockersHenleReabsorptionLimbRecent studies