2014
Postmenopausal Hypertension and Sodium Sensitivity
Kim JM, Kim TH, Lee HH, Lee SH, Wang T. Postmenopausal Hypertension and Sodium Sensitivity. Journal Of Menopausal Medicine 2014, 20: 1-6. PMID: 25371885, PMCID: PMC4217569, DOI: 10.6118/jmm.2014.20.1.1.Peer-Reviewed Original ResearchBlood pressureSystolic BPPostmenopausal hypertensionSex hormonesAngiotensin type 2 receptorElevation of SBPOral hormone replacement therapyAnti-aldosterone activityRenal regulatory mechanismsLow-salt dietDiastolic blood pressureHormone replacement therapySystolic blood pressureLack of estrogenPost-menopausal womenFemale sex hormonesType 2 receptorLow incidence rateNitric oxide productionBP controlNovel progestinArterial pressureSalt intakeReplacement therapyIncidence rate
2012
Genetic modifiers of hypertension in soluble guanylate cyclase α1–deficient mice
Buys ES, Raher MJ, Kirby A, Mohd S, Baron DM, Hayton SR, Tainsh LT, Sips PY, Rauwerdink KM, Yan Q, Tainsh RE, Shakartzi HR, Stevens C, Decaluwé K, da Gloria Rodrigues-Machado M, Malhotra R, Van de Voorde J, Wang T, Brouckaert P, Daly MJ, Bloch KD. Genetic modifiers of hypertension in soluble guanylate cyclase α1–deficient mice. Journal Of Clinical Investigation 2012, 122: 2316-2325. PMID: 22565307, PMCID: PMC3366402, DOI: 10.1172/jci60119.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCyclic GMPEndothelium, VascularFemaleGenetic LinkageGenome, HumanGuanylate CyclaseHumansHypertensionMaleMiceMice, KnockoutQuantitative Trait LociRatsReceptors, Cytoplasmic and NuclearReninRenin-Angiotensin SystemSecond Messenger SystemsSoluble Guanylyl CyclaseSpecies SpecificityVasodilationConceptsNitric oxideEndothelium-dependent vasorelaxationOnset of hypertensionVascular smooth muscleNO/cGMPSoluble guanylate cyclaseAdditional genetic factorsAldosterone systemRAAS inhibitionArterial pressureMale miceHypertensionSmooth muscleBlood flowGuanylate cyclaseMouse strainsΑ1 subunitGenetic factorsMiceReceptor componentsGenetic modifiersVasorelaxationRenin