Generation of Induced Pluripotent Stem Cells From Patients With Duchenne Muscular Dystrophy and Their Induction to Cardiomyocytes
Hashimoto A, Naito AT, Lee JK, Kitazume-Taneike R, Ito M, Yamaguchi T, Nakata R, Sumida T, Okada K, Nakagawa A, Higo T, Kuramoto Y, Sakai T, Tominaga K, Okinaga T, Kogaki S, Ozono K, Miyagawa S, Sawa Y, Sakata Y, Morita H, Umezawa A, Komuro I. Generation of Induced Pluripotent Stem Cells From Patients With Duchenne Muscular Dystrophy and Their Induction to Cardiomyocytes. International Heart Journal 2015, 57: 112-117. PMID: 26673445, DOI: 10.1536/ihj.15-376.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCell DifferentiationCells, CulturedHumansInduced Pluripotent Stem CellsMuscular Dystrophy, DuchenneMyocytes, CardiacReal-Time Polymerase Chain ReactionRNAConceptsDuchenne muscular dystrophyDMD patientsMuscular dystrophyYears of ageIPS cell-derived cardiomyocytesPatient-specific iPS cellsDMD cardiomyopathyCardiac dysfunctionCurative treatmentCell-derived cardiomyocytesT lymphocytesPatientsCardiac phenotypeSendai virus vectorCardiac muscleSkeletal muscleDystrophin defectsInduced pluripotent stem cellsCardiomyocytesCell linesStem cellsDystrophin proteinDystrophyPluripotent stem cellsMuscle