2012
Phospholipid Scramblase 1 Mediates Type I Interferon-Induced Protection against Staphylococcal α-Toxin
Lizak M, Yarovinsky TO. Phospholipid Scramblase 1 Mediates Type I Interferon-Induced Protection against Staphylococcal α-Toxin. Cell Host & Microbe 2012, 11: 70-80. PMID: 22264514, PMCID: PMC3266557, DOI: 10.1016/j.chom.2011.12.004.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsBacterial ToxinsBody TemperatureBody WeightCell LineCell SurvivalDisease Models, AnimalEpithelial CellsHemolysin ProteinsHumansInterferon-alphaLipoylationMiceMice, KnockoutPhospholipid Transfer ProteinsProtein Processing, Post-TranslationalStaphylococcal InfectionsStaphylococcus aureusSurvival AnalysisConceptsLung epithelial cellsI interferonΑ-toxinStaphylococcal α-toxinCytolytic activityPhospholipid scramblase 1Epithelial cellsInnate protective mechanismsCause of pneumoniaHuman lung epithelial cellsType I interferonAureus clinical isolatesPore-forming toxinsMajor virulence factorScramblase 1Intracellular ATP depletionPositive pathogen Staphylococcus aureusMice displayClinical isolatesAureus strainsProtective mechanismCellular depletionBacterial pore-forming toxinsVirulence factorsUnderlying mechanism
2007
Interferons Increase Cell Resistance to Staphylococcal Alpha-Toxin
Yarovinsky TO, Monick MM, Husmann M, Hunninghake GW. Interferons Increase Cell Resistance to Staphylococcal Alpha-Toxin. Infection And Immunity 2007, 76: 571-577. PMID: 18070901, PMCID: PMC2223481, DOI: 10.1128/iai.01088-07.Peer-Reviewed Original ResearchConceptsStaphylococcal infectionsIFN-alphaTumor necrosis factor alphaNecrosis factor alphaStaphylococcal alpha toxinFatty acid synthase activityCell resistancePore-forming toxinsProinflammatory mediatorsIL-6IL-4Factor alphaInterleukin-1betaIFN-gammaImportant virulence factorAlpha toxinDepletion of ATPIFN-betaProtective roleLipid metabolismMitogen-activated protein kinaseCaspase-1InterferonHost factorsPrior exposure