2019
Virus-like Vesicles Expressing Multiple Antigens for Immunotherapy of Chronic Hepatitis B
Yarovinsky TO, Mason SW, Menon M, Krady MM, Haslip M, Madina BR, Ma X, Moshkani S, Chiale C, Pal AC, Almassian B, Rose JK, Robek MD, Nakaar V. Virus-like Vesicles Expressing Multiple Antigens for Immunotherapy of Chronic Hepatitis B. IScience 2019, 21: 391-402. PMID: 31704650, PMCID: PMC6889364, DOI: 10.1016/j.isci.2019.10.040.Peer-Reviewed Original ResearchHepatitis B virusChronic hepatitis BHepatitis BSerum HBV surface antigenVirus-like vesiclesLiver HBV RNAPersistent HBV replicationHBV surface antigenImmune exhaustionChronic hepatitisHBV antigensHBV infectionBooster immunizationCD8 TChronic modelHBV replicationImmunotherapeutic approachesLiver injuryNaive miceHBV RNAB virusCurrent treatmentSurface antigenUnmet needMultiple antigens
2005
Increased Sensitivity to Staphylococcal Enterotoxin B following Adenoviral Infection
Yarovinsky TO, Mohning MP, Bradford MA, Monick MM, Hunninghake GW. Increased Sensitivity to Staphylococcal Enterotoxin B following Adenoviral Infection. Infection And Immunity 2005, 73: 3375-3384. PMID: 15908364, PMCID: PMC1111844, DOI: 10.1128/iai.73.6.3375-3384.2005.Peer-Reviewed Original ResearchConceptsStaphylococcal enterotoxin BAdenoviral infectionEnterotoxin BStaphylococcal enterotoxin B exposureD-galactosamine sensitizationSystemic adenoviral infectionIncreased sensitivityPrime miceMajor virulence factorLiver injuryProfound hypothermiaStaphylococcal diseaseMurine modelGamma interferonKnockout miceB exposureToxic shockInfectionStaphylococcal enterotoxinsMiceVirulence factorsIncreased productionExposureHypothermiaInjury