Oral Mucosal Sparing in High-Dose Total Body Irradiation (TBI) prior to Stem Cell Transplantation (SCT) for Acute Leukemia
Liveringhouse C, Sandoval M, Dohm A, Weygand J, Garcia G, Peters J, Nieder M, Faramand R, Jain M, Locke F, Bejanyan N, Kim S, Robinson T, Latifi K. Oral Mucosal Sparing in High-Dose Total Body Irradiation (TBI) prior to Stem Cell Transplantation (SCT) for Acute Leukemia. International Journal Of Radiation Oncology • Biology • Physics 2022, 114: e353. DOI: 10.1016/j.ijrobp.2022.07.1462.Peer-Reviewed Original ResearchNon-relapse mortalityTotal body irradiationStem cell transplantationHigh-grade oral mucositisPlanning target volumeOral mucositisAcute oral mucositisAcute lymphocytic leukemiaAcute leukemiaMucosal sparingOral mucosaExact testRisk of NRMHigh-dose total body irradiationDose total body irradiationHost disease (GVHD) prophylaxisResults 25 patientsMedian patient ageSevere oral mucositisFatal respiratory failureFisher's exact testNon-significant trendIMRT/VMATConditioning chemotherapyFatal GVHD